Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

2010 ◽  
Vol 9 (1) ◽  
pp. 53-61
Author(s):  
Jeremy P. Appleton ◽  
Peter Bridge
Keyword(s):  
Conservative Treatment ◽  
Proton Therapy ◽  
Normal Tissue ◽  
Treatment Options ◽  
Choroidal Melanoma ◽  
Review Of The Literature ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour ◽  
Plaque Brachytherapy

AbstractThe aims of conservative treatment in patients with ocular melanoma are globe retention, good visual acuity (VA) and local control. Two well-established radiation conservative treatment options are proton beam radiotherapy and episcleral plaque brachytherapy (EPB). Patients who receive treatment with either of these options will experience some degree of radiation-related ocular complications and poor VA. The purpose of this review of the literature is to establish whether there is a significant clinical difference in normal tissue morbidity and local tumour control between proton therapy and EPB, and whether this difference can justify the purchase and implementation of additional proton therapy facilities. Based on this review, evidence suggested that both treatment options are comparable, and that neither proton therapy nor EPB is clinically superior than the other regarding normal tissue morbidity and local tumour control. This review highlighted the need for further research on a larger scale in order to bridge the gap that is apparent within the literature.

scholarly journals Interactions between radiotherapy and endocrine therapy in breast cancer.

2002 ◽  
pp. 197-205 ◽  
Author(s):  
R del Moral ◽  
M E L√≥pez ◽  
M I N√∫√±ez ◽  
F J Oliver ◽  
M T Valenzuela ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormonal Therapy ◽  
Normal Tissue ◽  
Treatment Options ◽  
Tumour Response ◽  
Tissue Response ◽  
Curative Intent ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Whenever radiation therapy is given with curative intent there is the risk of serious damage to normal tissue. This risk increases with the dose of radiation, as does the probability of local tumour control. In the attempt to cure, the doses reach a level that inevitably causes some undesirable adverse effects, ranging from undetectable, or minimal, to unacceptably severe. Over the last few years, a number of reports have suggested that the prediction of normal tissue response after radiotherapy may be achieved by assays on samples withdrawn from the patients prior to treatment, although recent reports have described mixed results. The ability to predict tumour response to anti-hormones in patients with breast cancer has important implications with regard to treatment. Recent discoveries promise to provide individualized treatment options. However, there are no data to support that, used jointly, the combination of radiotherapy and hormone therapy may achieve an enhancement of breast cancer tumour response. Nowadays, development in cancer therapy is increasingly arising out of studies in basic science; its implementation in the hands of clinicians is improving the management of patients with cancer. In addition, as the biological aspects of irradiation and hormonal therapy offer an explanation, at least in part, for the outcome observed in patients with breast cancer after therapy, we have focused this review on trying to analyse the most relevant experimental research about the relative roles of radiotherapy and hormonal therapy, the corresponding side-effects and, taking into account recent advances, future areas of research that we consider of major importance in the field.

What accuracy is required and can be achieved in radiation therapy (review of radiobiological and clinical data)

2001 ◽  
Vol 89 (4-5) ◽  
Author(s):  
A. Wambersie
Keyword(s):  
Radiation Therapy ◽  
Standard Deviation ◽  
Clinical Data ◽  
Normal Tissue ◽  
Absorbed Dose ◽  
Dose Effect ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Treatment Conditions ◽  
Local Tumour

An attempt is made to formulate the requirements for the accuracy in the delivery of absorbed dose to a patient during radiation therapy. These requirements are mainly based on the relative steepness and separation of the dose-effect curves for local tumour control and normal tissue damage. The curves for normal tissue complications in general may be steeper than those for local tumour control. From these data, a standard requirement of 3.5% is proposed for the combined uncertainty of type A (random) and type B (systematic), given as one relative standard deviation in the absorbed dose delivery. However, it is recognized that, in many cases, larger uncertainties are acceptable palliative treatments). This value of 3.5% applies to the absorbed dose at the specification point for curative treatments. As far as the dose accuracy requirements at other points in the planning target volume are concerned, a value of 5% (one standard deviation) seems more appropriate. This required accuracy in the delivery of the absorbed dose cannot always be completely achieved in photon therapy even for simple treatment conditions. All the clinical data which were reviewed, including some results from the ldquo;Patterns of Care Study”, indicate a close correlation between the outcomes of therapy (control rates, complications) and dose level, inaccuracy or errors in dosimetry and patient-machine positioning. This has been reported for external beam therapy as well as for brachytherapy. Only the clinical results will allow us to select the optimal treatment conditions (e.g. selection and definition of the planning target volumes, dose levels and beam arrangement), but they could be interpreted correctly only to the extent that the treatment execution would be correct. This result strongly endorses the Quality Assurance Programmes, in which the clinicians and physicists should be fully involved. Lastly, the outcome of a treatment can only be interpreted meaningfully if the parameters of the irradiation, in particular, the distribution of dose in space and time can be accurately correlated with the type and extent of the disease. It is essential that clear, well defined and unambiguous concepts and parameters be used for reporting purposes to ensure a common language between collaborating centres. This is one of the major tasks that the ICRU undertook several years ago.

Visual outcome, local tumour control, and eye preservation after106Ru/Rh brachytherapy for choroidal melanoma

2006 ◽  
Vol 45 (3) ◽  
pp. 285-293 ◽  
Author(s):  
Peter Isager ◽  
Niels Ehlers ◽  
Steen F Urbak ◽  
Jens Overgaard
Keyword(s):  
Choroidal Melanoma ◽  
Visual Outcome ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Nuklearmedizin trifft Strahlentherapie

2010 ◽  
Vol 49 (S 01) ◽  
pp. S11-S15
Author(s):  
C. Schütze ◽  
M. Krause ◽  
A. Yaromina ◽  
D. Zips ◽  
M. Baumann
Keyword(s):  
Nuclear Medicine ◽  
Radiation Oncology ◽  
External Beam Radiotherapy ◽  
Biological Knowledge ◽  
Important Research ◽  
Tumour Control ◽  
Research Areas ◽  
Normal Tissue Damage ◽  
Local Tumour Control ◽  
Local Tumour

SummaryRadiobiological and cell biological knowledge is increasingly used to further improve local tumour control or to reduce normal tissue damage after radiotherapy. Important research areas are evolving which need to be addressed jointly by nuclear medicine and radiation oncology. For this differences of the biological distribution of diagnostic and therapeutic nuclides compared with the more homogenous dose-distribution of external beam radiotherapy have to be taken into consideration. Examples for interdisciplinary biology-based cancer research in radiation oncology and nuclear medicine include bioimaging of radiobiological parameters characterizing radioresistance, bioimage-guided adaptive radiotherapy, and the combination of radiotherapy with molecular targeted drugs.

PO-1926 Enhanced local tumour control by combining proton radiation and immunotherapy

2021 ◽  
Vol 161 ◽  
pp. S1642
Author(s):  
M. Horsman ◽  
S. Nielsen ◽  
M. Sitarz ◽  
M. Høyer ◽  
B. Sørensen
Keyword(s):  
Proton Radiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

scholarly journals Extensive systemic metastases from primary central nervous system haemangiopericytoma

2020 ◽  
Vol 6 (2) ◽  
pp. 20190081
Author(s):  
Chi Long Ho ◽  
Jeremy JH Lam ◽  
Robert Chun Chen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Fatal Outcome ◽  
Imaging Features ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Meningeal Tumour ◽  
Local Tumour ◽  
The Central Nervous System ◽  
Extracranial Metastases

Primary intracranial tumours rarely metastasise outside of the central nervous system (CNS). This report describes a rare case of recurrent meningeal haemangiopericytoma with extensive systemic metastases, which eventually resulted in a fatal outcome. We discuss some prevailing theories as to the rarity of extracranial metastases from primary CNS haemangiopericytoma, and elucidate the epidemiology, imaging features, differential diagnosis, treatment, and prognosis of this unusual but surprisingly aggressive meningeal tumour. Besides aggressive treatment for local tumour control, patients with primary CNS haemangiopericytoma require long-term post-treatment surveillance to detect systemic metastases.

Residual γH2AX foci predict local tumour control after radiotherapy

2013 ◽  
Vol 108 (3) ◽  
pp. 434-439 ◽  
Author(s):  
Ulrike Koch ◽  
Katharina Höhne ◽  
Cläre von Neubeck ◽  
Howard D. Thames ◽  
Ala Yaromina ◽  
...  
Keyword(s):  
Tumour Control ◽  
Γh2ax Foci ◽  
Local Tumour Control ◽  
Local Tumour

Nd:YAG laser in penile diseases. Indications and limits

1996 ◽  
Vol 63 (1) ◽  
pp. 86-90
Author(s):  
E. Dotti ◽  
F. Gaboardi ◽  
A. Bozzola ◽  
T. Zago ◽  
L. Galli
Keyword(s):  
Nd:Yag Laser ◽  
Local Anaesthesia ◽  
Penile Cancer ◽  
Early Stage ◽  
Western World ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Good Cosmetic ◽  
Local Tumour ◽  
Penile Diseases

— Penile cancer is an uncommon malignancy in the western world (1–2% of all malignancies in males). Traditionally it is treated by penis amputation. Today with laser therapy a new opportunity is offered. 16 patients referred to our Dept. for early stage penile cancer. 2 TIS, 7 T1, 1 T2 penile cancer and 6 with Erythroplasia of Queyrat. Before treatment the patients underwent cold biopsy in order to establish the tumour grading and staging of malignancy. A laser irradiation was performed under local anaesthesia using 25–35 Watt/3 sec in the penile cancer and 15–20 Watt/2 sec in the Erytroplasia of Queyrat. There were no complications after treatment. All patients were observed during follow-up every month after the irradiation until the sixth month and then every 3 months. No-one developed local recurrence or metastatic disease: Nd:YAG laser seems to offer a safe, easy treatment compared to traditional surgery. It can be performed under local, anaesthesia without bleeding, permits good local tumour control, a good cosmetic aspect and, finally full functionality of the penis.

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