scholarly journals Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex

Redox Biology ◽  
2021 ◽  
pp. 102057
Author(s):  
Kazuya Toriumi ◽  
Stefano Berto ◽  
Shin Koike ◽  
Noriyoshi Usui ◽  
Takashi Dan ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Mitochondrial Dysfunction ◽  
Vitamin B6 ◽  
Model System ◽  
Glyoxalase 1 ◽  
Vitamin B6 Deficiency

Membrane-associated microtubular areays induced in proximal myelinated processes of dorsal root ganglia by large doses of vitamin B6

1986 ◽  
Vol 44 ◽  
pp. 368-369
Author(s):  
V.J. Montpetit ◽  
S. Dancea ◽  
L. Tryphonas ◽  
D.F. Clapin
Keyword(s):  
Animal Model ◽  
Endoplasmic Reticulum ◽  
Dorsal Root Ganglia ◽  
Rough Endoplasmic Reticulum ◽  
Dorsal Root ◽  
Vitamin B6 ◽  
Morphological Changes ◽  
Model System ◽  
Sensory Nerves ◽  
Peripheral Sensory

Very large doses of pyridoxine (vitamin B6) are neurotoxic in humans, selectively affecting the peripheral sensory nerves. We have undertaken a study of the morphological and biochemical aspects of pyridoxine neurotoxicity in an animal model system. Early morphological changes in dorsal root ganglia (DRG) associated with pyridoxine megadoses include proliferation of neurofilaments, ribosomes, rough endoplasmic reticulum, and Golgi complexes. We present in this report evidence of the formation of unique aggregates of microtubules and membranes in the proximal processes of DRG which are induced by high levels of pyridoxine.

scholarly journals Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ashley M. Fields ◽  
Kevin Welle ◽  
Elaine S. Ho ◽  
Clementina Mesaros ◽  
Martha Susiarjo
Keyword(s):  
Cell Proliferation ◽  
Insulin Secretion ◽  
Pancreatic Islets ◽  
Glucose Intolerance ◽  
Vitamin B6 ◽  
Serotonin Receptor ◽  
Dependent Manner ◽  
Β Cell ◽  
Vitamin B6 Deficiency ◽  
Maternal Glucose

AbstractIn pancreatic islets, catabolism of tryptophan into serotonin and serotonin receptor 2B (HTR2B) activation is crucial for β-cell proliferation and maternal glucose regulation during pregnancy. Factors that reduce serotonin synthesis and perturb HTR2B signaling are associated with decreased β-cell number, impaired insulin secretion, and gestational glucose intolerance in mice. Albeit the tryptophan-serotonin pathway is dependent on vitamin B6 bioavailability, how vitamin B6 deficiency impacts β-cell proliferation during pregnancy has not been investigated. In this study, we created a vitamin B6 deficient mouse model and investigated how gestational deficiency influences maternal glucose tolerance. Our studies show that gestational vitamin B6 deficiency decreases serotonin levels in maternal pancreatic islets and reduces β-cell proliferation in an HTR2B-dependent manner. These changes were associated with glucose intolerance and insulin resistance, however insulin secretion remained intact. Our findings suggest that vitamin B6 deficiency-induced gestational glucose intolerance involves additional mechanisms that are complex and insulin independent.

Reaction patterns of cell organelles in vitamin B6 deficiency

1980 ◽  
Vol 170 (4) ◽  
pp. 376-387 ◽  
Author(s):  
U.N. Riede ◽  
W. Sandritter ◽  
A. Pietzsch ◽  
R. Rohrbach
Keyword(s):  
Vitamin B6 ◽  
Cell Organelles ◽  
Vitamin B6 Deficiency ◽  
Reaction Patterns

A Cartilage Matrix Deficiency Experimentally Induced by Vitamin B6 Deficiency

1998 ◽  
Vol 217 (1) ◽  
pp. 97-103 ◽  
Author(s):  
P. G. Masse ◽  
I. Ziv ◽  
D. E. C. Cole ◽  
J. D. Mahuren ◽  
S. M. Donovan ◽  
...  
Keyword(s):  
Vitamin B6 ◽  
Cartilage Matrix ◽  
Vitamin B6 Deficiency ◽  
Experimentally Induced

Effect of vitamin B6 deficiency on the expression of glycogen phosphorylase mRNA in rat liver and skeletal muscle

1994 ◽  
Vol 50 (2) ◽  
pp. 127-129 ◽  
Author(s):  
T. Oka ◽  
N. Komori ◽  
M. Kuwahata ◽  
I. Suzuki ◽  
M. Okada ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Rat Liver ◽  
Vitamin B6 ◽  
Glycogen Phosphorylase ◽  
Vitamin B6 Deficiency

The Effect of Moderate Vitamin B6 Deficiency on Immunological and Hematological Parameters of Adult Female Rats

1990 ◽  
Vol 587 (1) ◽  
pp. 292-293
Author(s):  
D. S. KELLEY ◽  
M. C. SCHAEFFER ◽  
D. A. SAMPSON ◽  
P. C. TAYLOR ◽  
Y. M. RIVERA
Keyword(s):  
Adult Female ◽  
Vitamin B6 ◽  
Hematological Parameters ◽  
Female Rats ◽  
Vitamin B6 Deficiency

Vitamin B6 deficiency alters tissue iron concentrations in the Wistar rat

2009 ◽  
Vol 23 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Irene Mackraj ◽  
Govender Thirumala ◽  
Premjith Gathiram
Keyword(s):  
Vitamin B6 ◽  
Wistar Rat ◽  
Tissue Iron ◽  
Vitamin B6 Deficiency ◽  
Iron Concentrations

Vitamin B6 Deficiency in Chicks

1939 ◽  
Vol 42 (1) ◽  
pp. 180-182 ◽  
Author(s):  
T. H. Jukes
Keyword(s):  
Vitamin B6 ◽  
Vitamin B6 Deficiency
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