Effects of synthetic amorphous silica nanoparticle (NM-203) on male and female reproductive systems following 90-days repeated-dose oral administration in rat

2016 ◽  
Vol 64 ◽  
pp. 42-43
Author(s):  
Laura Narciso ◽  
Roberta Tassinari ◽  
Eugenia Cordelli ◽  
Paola Villani ◽  
Patrizia Eleuteri ◽  
...  
2009 ◽  
Vol 34 (5) ◽  
pp. 527-539 ◽  
Author(s):  
Sayuri Kojima ◽  
Junya Sasaki ◽  
Mariko Tomita ◽  
Machiko Saka ◽  
Katsumi Ishizuka ◽  
...  

1991 ◽  
Vol 3 (3) ◽  
pp. 162-166 ◽  
Author(s):  
Rocco Orlando ◽  
Annalisa Fragasso ◽  
Claudio Benvenuti ◽  
Lajos Okolicsanyi

2000 ◽  
Vol 61 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Jonathan N. King ◽  
Max P. Maurer ◽  
Bernd O. Altmann ◽  
Günther A. Strehlau

1994 ◽  
Vol 33 (2) ◽  
pp. 289-297 ◽  
Author(s):  
K. W. T. Tsang ◽  
P. Roberts ◽  
R. C. Read ◽  
F. Kees ◽  
R. Wilson ◽  
...  

2016 ◽  
Vol 88 (8) ◽  
pp. 713-830
Author(s):  
John H. Duffus ◽  
Michael Schwenk ◽  
Douglas M. Templeton

Abstract The primary objective of this glossary is to give clear definitions for those who contribute to studies relevant to these disciplines, or who must interpret them, but are not themselves reproductive physiologists or physicians. This applies especially to chemists who need to understand the literature of reproductive and teratogenic effects of substances without recourse to a multiplicity of other glossaries or dictionaries. The glossary includes terms related to basic and clinical reproductive biology and teratogenesis, insofar as they are necessary for a self-contained document, particularly terms related to diagnosing, measuring, and understanding the effects of substances on the embryo, the fetus, and on the male and female reproductive systems. The glossary consists of about 1200 primary alphabetical entries and includes Annexes of common abbreviations and examples of chemicals with known effects on human reproduction and development. The authors hope that toxicologists, pharmacologists, medical practitioners, risk assessors, and regulatory authorities are among the groups who will find this glossary helpful, in addition to chemists. In particular, the glossary should facilitate the worldwide use of chemical terminology in relation to occupational and environmental risk assessment.


Author(s):  
João P. Vareda ◽  
Carlos A. García-González ◽  
Artur J. M. Valente ◽  
Rosana Simón-Vázquez ◽  
Marina Stipetic ◽  
...  

The toxicity and ecotoxicity effects, handling and disposal of synthetic amorphous silica nanoparticles and aerogels are reviewed and discussed.


2021 ◽  
pp. 074823372110105
Author(s):  
Roberta Tassinari ◽  
Andrea Martinelli ◽  
Mauro Valeri ◽  
Francesca Maranghi

Synthetic amorphous silica (SAS) nanomaterial – consisting of aggregates and agglomerates of primary silicon dioxide (SiO2) particles in the nanorange (<100 nm) – is commonly used as excipient in pharmaceuticals, in cosmetics and as food additive (E551). The available data suggest that SAS nanoparticles (NP) after intravenous (IV) exposure persist in liver and spleen; however, insufficient data exist to verify whether SAS may also induce adverse effects. The aim of the present study was to verify the potential long-term effects of SAS NP (NM-203) on spleen and liver as target organs following short-term exposure. Adult male and female Sprague-Dawley rats were treated by IV injection in the tail vein with a single (1-day) dose (SD) and repeated (5-day) doses (RD) of 20 mg/kg bw per day of SAS dispersed in sterile saline solution as vehicle. Histopathological examinations of target organs were performed after 90 days. Tissue biodistribution and full characterization of NM-203, primary particle size 13–45 nm, was performed within the framework of the Nanogenotox project. No mortality or general toxicity occurred; histopathological analysis showed splenomegaly in the RD group accompanied by inflammatory granulomas in both sexes. Granulomas were also present in liver parenchyma in the RD (both sexes) and SD groups (male only). The histopathological results indicated that SAS NP have the potential to persist and induce sex-specific chronic inflammatory lesions in spleen and liver upon short-term treatment. Overall, the data showed that the widespread use of silica in drugs might elicit chronic reactions in spleen and liver prompting to the need of further investigations on the safety of SAS NP.


1999 ◽  
Vol 19 (8) ◽  
pp. 887-894 ◽  
Author(s):  
Yu-Ichiro Satoh ◽  
Kyoko Kasama ◽  
Mikiko Kuwabara ◽  
Hong-Yan Diao ◽  
Hirofumi Nakajima ◽  
...  

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