New homologous series of biomarker molecules from Vendian deposits of the Sayan-adjacent Biryusa area

Homologation is a concept introduced by Gerhard in 1853 to describe a homologous series in organic chemistry. Since then, the concept has been adapted and used in medicinal chemistry as one of the most important strategies for molecular modification. The homologation types, their influence on physico-chemical properties and molecular conformation are presented and discussed. Its application in lead-identification and lead optimization steps, as well as its impact on pharmacodynamics/pharmacokinetic properties and on protein structure is highlighted from selected examples. • Homologation: definition and types • Homologous series in nature • Comparative physico-chemical and conformational properties • Application in lead-identification and lead-optimization • Impact on pharmacodynamic property • Impact on pharmacokinetic property • Impact on protein structure • Concluding remarks • Acknowledgment • References

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The effect of steric size of leaving group on rates of the competing syn- and anti-pathways in biomolecular elimination

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19802171 ◽

1980 ◽

Vol 45 (8) ◽

pp. 2171-2178

Author(s):

Jiří Závada ◽

Magdalena Pánková

Keyword(s):

Comparative Analysis ◽

Homologous Series ◽

Leaving Group ◽

Leaving Groups

Approximate rates of the competing syn- and anti-pathways have been determined in t-C4H9OK-t-C4H9OH promoted elimination from two homologous series of tosylates: I-OTs trans-III (R = H, CH3, C2H5, n-C3H7, i-C3H7, t-C4H9) and II-OTs trans-IV (R = CH3, C2H5, n-C3H7, i-C3H7, t-C4H9). A comparison has been made with rates of the same processes in the (+) elimination of the corresponding trimethylammonium salts I-N(CH3)3 trans-III and (+) II-N(CH3)3 trans-IV. The title effect is demonstrated by a comparative analysis of the rate patterns obtained for the two leaving groups.

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Pavonite homologues as potential n-type thermoelectric materials: crystal structure and performance

Materials Chemistry Frontiers ◽

10.1039/d0qm00662a ◽

2021 ◽

Author(s):

Shangqing Qu ◽

Jing Zhao ◽

Zimin Jiang ◽

Dequan Jiang ◽

Yonggang Wang

Keyword(s):

Crystal Structure ◽

Thermoelectric Material ◽

Thermoelectric Materials ◽

Homologous Series ◽

And Performance

The pavonite homologous series assembled from two basic modules is a potential n-type thermoelectric material.

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Surface Energies of Nonionic Surfactants Adsorbed onto Nylon Fiber and a Correlation with Their Solubility Parameters

Textile Research Journal ◽

10.1177/004051759206200907 ◽

1992 ◽

Vol 62 (9) ◽

pp. 535-546 ◽

Cited By ~ 2

Author(s):

Philip E. Slade ◽

Debra N. Hild

Keyword(s):

Homologous Series ◽

Nonionic Surfactants ◽

Solubility Parameters ◽

Nylon 66 ◽

Synthetic Fibers ◽

Surface Energies ◽

Nylon Fiber

The surface energies of spin finishes adsorbed onto synthetic fibers are a major factor in determining the processing capabilities of these fibers. They also play a key role in determining how wettable the fibers are by other materials that may be applied to yarn or fabrics in later stages of processing, such as dyes, sizes, or anti-soiling agents. We have applied several homologous series of nonionic surfactants, which can be used as spin finish emulsifiers, to nylon 66 fibers and determined the polar, dispersion, and total surface energies of these adsorbed materials. We also propose a relationship between the measured surface energies and the calculated Hansen fractional solubility parameters.

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