scholarly journals Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: Relationship with fatty acid composition

2009 ◽  
Vol 109 (1-3) ◽  
pp. 113-120 ◽  
Author(s):  
Yanhong Liu ◽  
Ronald Jandacek ◽  
Therese Rider ◽  
Patrick Tso ◽  
Robert K. McNamara
Keyword(s):  
Fatty Acid Composition ◽  
Prefrontal Cortex ◽  
Fatty Acid ◽  
Acid Composition ◽  
Schizophrenic Patients ◽  
Delta 6 Desaturase

scholarly journals Fatty acid desaturation and microsomal lipid fatty acid composition in experimental hypothyroidism

1982 ◽  
Vol 207 (1) ◽  
pp. 29-35 ◽  
Author(s):  
F H Faas ◽  
W J Carter
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Desaturase Activity ◽  
Unsaturated Fatty Acids ◽  
Lipid Fatty Acid ◽  
Rate Controlling Step ◽  
Delta 6 Desaturase ◽  
Lipid Fatty Acid Composition

We have studied the influence of experimental hypothyroidism in the rat on the synthesis of unsaturated fatty acids and on liver microsomal lipid fatty acid composition. Hypothyroid rats demonstrated an 80% decrease in delta 9 (stearate) desaturation and a 43% decrease in delta 6 (linoleate) desaturation. Liver microsomal fatty acid composition was altered in the hypothyroid animals with a significantly decreased proportion of arachidonate and increased proportions of linoleate, eicosa-8,11,14-trienoate, eicosapentaenoate and docosahexaenoate. The bulk of these changes occurred in both of the two major phospholipid components, phosphatidylcholine and phosphatidylethanolamine. All of the changes were corrected by treatment of the hypothyroid rat with 25 micrograms of tri-iodothyronine/100 g body wt. twice daily. The diminished delta 9 desaturation did not lead to any changes in fatty acid composition. The increased linoleate and decreased arachidonate levels may be due to the diminished delta 6 desaturase activity, the rate-controlling step in the conversion of linoleate into arachidonate. The increases in the proportions of the other polyunsaturated fatty acid components cannot be explained by changes in the synthesis of unsaturated fatty acids, but are probably due to diminished utilization of these fatty acids.

scholarly journals Dietary n-6/n-3 Ratio Influences Brain Fatty Acid Composition in Adult Rats

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1847 ◽  
Author(s):  
Thomas Horman ◽  
Maria F. Fernandes ◽  
Maria C. Tache ◽  
Barbora Hucik ◽  
David M. Mutch ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Prefrontal Cortex ◽  
Fatty Acid ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Sprague Dawley ◽  
Alpha Linolenic Acid ◽  
Adult Rats ◽  
The Brain

There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated whether moderately high-fat diets differing in n-6/n-3 fatty acid ratio could impact fatty acid composition in regions of the brain linked to various psychopathologies. Adult male Sprague Dawley rats consumed isocaloric diets (35% kcal from fat) containing different ratios of linoleic acid (n-6) and alpha-linolenic acid (n-3) for 2 months. It was found that the profiles of PUFA in the prefrontal cortex, hippocampus, and hypothalamus reflected the fatty acid composition of the diet. In addition, region-specific changes in saturated fatty acids and monounsaturated fatty acids were detected in the hypothalamus, but not in the hippocampus or prefrontal cortex. This study in adult rats demonstrates that fatty acid remodeling in the brain by diet can occur within months and provides additional evidence for the suggestion that diet could impact mental health.

Regulation of growth, fatty acid composition and delta 6 desaturase expression by dietary lipids in gilthead seabream larvae (Sparus aurata)

2007 ◽  
Vol 34 (2) ◽  
pp. 117-127 ◽  
Author(s):  
M. S. Izquierdo ◽  
Lidia Robaina ◽  
Eduardo Juárez-Carrillo ◽  
V. Oliva ◽  
Carmen María Hernández-Cruz ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Sparus Aurata ◽  
Dietary Lipids ◽  
Gilthead Seabream ◽  
Regulation Of Growth ◽  
Delta 6 Desaturase

Membrane fatty acid composition of fibroblasts from schizophrenic patients

1994 ◽  
Vol 35 (9) ◽  
pp. 700-701 ◽  
Author(s):  
S. Mukherjee ◽  
S.P. Mahadik ◽  
D.F. Horrobin ◽  
K. Jenkins ◽  
E.E. Correnti ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Membrane Fatty Acid ◽  
Membrane Fatty Acid Composition ◽  
Schizophrenic Patients

Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims

2009 ◽  
Vol 80 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Robert K. McNamara ◽  
Ronald Jandacek ◽  
Therese Rider ◽  
Patrick Tso ◽  
Yogesh Dwivedi ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Prefrontal Cortex ◽  
Fatty Acid ◽  
Acid Composition ◽  
Adolescent Male ◽  
Male And Female ◽  
Female Suicide
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