scholarly journals Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study

2013 ◽  
Vol 143 (2-3) ◽  
pp. 231-238 ◽  
Author(s):  
Sang-Hyuk Lee ◽  
Marek Kubicki ◽  
Takeshi Asami ◽  
Larry J. Seidman ◽  
Jill M. Goldstein ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
First Episode ◽  
White Matter Abnormalities ◽  
First Episode Schizophrenia ◽  
Diffusion Tensor Imaging Dti

White Matter Abnormalities in First-Episode Schizophrenia or Schizoaffective Disorder: A Diffusion Tensor Imaging Study

2005 ◽  
Vol 162 (3) ◽  
pp. 602-605 ◽  
Author(s):  
Philip R. Szeszko ◽  
Babak A. Ardekani ◽  
Manzar Ashtari ◽  
Sanjiv Kumra ◽  
Delbert G. Robinson ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Schizoaffective Disorder ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
First Episode ◽  
White Matter Abnormalities ◽  
First Episode Schizophrenia ◽  
Diffusion Tensor Imaging Study

Gray and white matter volumetric and diffusion tensor imaging (DTI) analyses in the early stage of first-episode schizophrenia

2010 ◽  
Vol 116 (2-3) ◽  
pp. 196-203 ◽  
Author(s):  
Junji Moriya ◽  
Shingo Kakeda ◽  
Osamu Abe ◽  
Naoki Goto ◽  
Reiji Yoshimura ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Early Stage ◽  
First Episode ◽  
First Episode Schizophrenia ◽  
And Diffusion ◽  
Diffusion Tensor Imaging Dti

scholarly journals A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia

2007 ◽  
Vol 38 (6) ◽  
pp. 877-885 ◽  
Author(s):  
V. Cheung ◽  
C. Cheung ◽  
G. M. McAlonan ◽  
Y. Deng ◽  
J. G. Wong ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
Structural Connectivity ◽  
First Episode ◽  
Cerebral Peduncle ◽  
Healthy Controls ◽  
Subcortical Region ◽  
First Episode Schizophrenia

BackgroundDiffusion tensor imaging (DTI) can be used to investigate cerebral structural connectivity in never-medicated individuals with first-episode schizophrenia.MethodSubjects with first-episode schizophrenia according to DSM-IV-R who had never been exposed to antipsychotic medication (n=25) and healthy controls (n=26) were recruited. Groups were matched for age, gender, best parental socio-economic status and ethnicity. All subjects underwent DTI and structural magnetic resonance imaging (MRI) scans. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values differed significantly between groups. A confirmatory region-of-interest (ROI) analysis of FA scores was performed in which regions were placed blind to group membership.ResultsIn patients, FA values significantly lower than those in healthy controls were located in the left fronto-occipital fasciculus, left inferior longitudinal fasciculus, white matter adjacent to right precuneus, splenium of corpus callosum, right posterior limb of internal capsule, white matter adjacent to right substantia nigra, and left cerebral peduncle. ROI analysis of the corpus callosum confirmed that the patient group had significantly lower mean FA values than the controls in the splenium but not in the genu. The intra-class correlation coefficient (ICC) for independent ROI measurements was 0.90 (genu) and 0.90 (splenium). There were no regions where FA values were significantly higher in the patients than in the healthy controls.ConclusionsWidespread structural dysconnectivity, including the subcortical region, is already present in neuroleptic-naive patients in their first episode of illness.

Assessment of white matter abnormalities in paranoid schizophrenia and bipolar mania patients from Chengdu, China

2011 ◽  
Vol 26 (S2) ◽  
pp. 940-940
Author(s):  
L. Cui ◽  
Z. Chen ◽  
W. Deng ◽  
X. Huang ◽  
M. Li ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Paranoid Schizophrenia ◽  
Health Centre ◽  
White Matter Abnormalities ◽  
Diagnostic And Statistical Manual ◽  
Bipolar Mania ◽  
Shared Risk ◽  
Diffusion Tensor Imaging Dti

IntroductionWhite matter abnormalities have been repeatedly reported in both schizophrenia and bipolar disorder (BD) diseases from diffusion tensor imaging (DTI) studies respectively, while the empirical evidences about the diagnostic specificity of white matter abnormalities in these disorders are still limited.Objectives25 patients with paranoid schizophrenia and 18 patients with bipolar mania were recruited from the in-patient unit of the Mental Health Centre, West China Hospital, China.Patients were diagnosed according to the criteria of Diagnostic and Statistical Manual of Mental Disorders-Version IV (DSM- IV). 30 healthy controls were recruited from the community by means of leaflets distributed throughout Chengdu city.AimsThis study sought to investigate the alterations in fractional anisotropy (FA) in white matter throughout the entire brain of patients from Chengdu, China with paranoid schizophrenia and bipolar mania.MethodsDiffusion tensor imaging (DTI) was used to assess white matter integrity in patients with paranoid schizophrenia and bipolar mania, as well as in normal controls. The differences in FA were measured by use of voxel-based analysis.ResultsReduced FA was found in the left posterior corona radiate (PCR) in patients with bipolar mania and paranoid schizophrenia compared to the controls. Patients with bipolar mania also showed a significant reduction in FA in right posterior corona radiate and in right anterior thalamic radiation (ATR).ConclusionsCommon abnormalities in the left PCR might imply an overlap in white matter pathology of both diseases and might be related to the shared risk factors for both disorders.

Diffusion tensor imaging in schizophrenia

2008 ◽  
Vol 23 (4) ◽  
pp. 255-273 ◽  
Author(s):  
Marinos Kyriakopoulos ◽  
Theodoros Bargiotas ◽  
Gareth J. Barker ◽  
Sophia Frangou
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Brain Regions ◽  
Basic Principles ◽  
Future Directions ◽  
White Matter Abnormalities ◽  
Non Invasive ◽  
Brain White Matter ◽  
Diffusion Tensor Imaging Dti

AbstractDiffusion tensor imaging (DTI) is a magnetic resonance imaging technique that is increasingly being used for the non-invasive evaluation of brain white matter abnormalities. In this review, we discuss the basic principles of DTI, its roots and the contribution of European centres in its development, and we review the findings from DTI studies in schizophrenia. We searched EMBASE, PubMed, PsychInfo, and Medline from February 1998 to December 2006 using as keywords ‘schizophrenia’, ‘diffusion’, ‘tensor’, and ‘DTI’. Forty studies fulfilling the inclusion criteria of this review were included and systematically reviewed. White matter abnormalities in many diverse brain regions were identified in schizophrenia. Although the findings are not completely consistent, frontal and temporal white matter seems to be more commonly affected. Limitations and future directions of this method are discussed.

CEREBRAL WHITE MATTER CHANGES ON COMBINED STRUCTURAL MRI AND DIFFUSION TENSOR IMAGING IN FIRST EPISODE SCHIZOPHRENIA

2010 ◽  
Vol 117 (2-3) ◽  
pp. 461-462
Author(s):  
Kang Sim ◽  
W.Y. Chan ◽  
M.Y. Chia ◽  
G.L. Yang ◽  
Y.Y. Sitoh ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Structural Mri ◽  
First Episode ◽  
Cerebral White Matter ◽  
White Matter Changes ◽  
First Episode Schizophrenia ◽  
And Diffusion
Sign in / Sign up

Export Citation Format

Share Document