A longitudinal study on the relationship between duration of untreated psychosis and executive function in early-onset first-episode psychosis

AbstractObjectives: To examine the relationship between cognitive deficits, the duration of untreated psychosis (DUP) and positive and negative symptoms in a first episode psychosis sample.Method: We assessed a consecutive sample of first episode psychosis participants from a catchment area service with a comprehensive neuropsychology battery, a family and service-user based measure of DUP and measures of symptomatology.Results: Using correlations and stepwise linear regressions, we found strong relationships between measures of DUP and positive symptomatology. We found that positive and negative symptoms were associated with different time periods within DUP. However, we did not find evidence of a relationship between DUP and cognitive factors.Conclusions: There was no evidence of a relationship between DUP and cognitive deterioration. However, there does appear to be evidence of a relationship between positive symptoms and aspects of DUP. These results highlight the importance of the heterogeneity of DUP and the potential to reduce positive symptoms through early intervention.

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Failure to find association between childhood abuse and cognition in first-episode psychosis patients

European Psychiatry ◽

10.1016/j.eurpsy.2013.02.006 ◽

2014 ◽

Vol 29 (1) ◽

pp. 32-35 ◽

Cited By ~ 14

Author(s):

L. Sideli ◽

H.L. Fisher ◽

M. Russo ◽

R.M. Murray ◽

S.A. Stilo ◽

...

Keyword(s):

Executive Function ◽

Childhood Abuse ◽

Cognitive Functions ◽

First Episode Psychosis ◽

First Episode ◽

Control Group ◽

Episode Psychosis ◽

Function Domain ◽

The Relationship

AbstractThis study investigated the relationship between severe childhood abuse and cognitive functions in first-episode psychosis patients and geographically-matched controls. Reports of any abuse were associated with lower scores in the executive function domain in the control group. However, in contrast with our hypothesis, no relationships were found amongst cases.

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Insight, duration of untreated psychosis and attachment in first-episode psychosis: prospective study of psychiatric recovery over 12-month follow-up

The British Journal of Psychiatry ◽

10.1192/bjp.bp.113.126722 ◽

2014 ◽

Vol 205 (1) ◽

pp. 60-67 ◽

Cited By ~ 34

Author(s):

A. I. Gumley ◽

M. Schwannauer ◽

A. Macbeth ◽

R. Fisher ◽

S. Clark ◽

...

Keyword(s):

Negative Symptoms ◽

Attachment Security ◽

First Episode Psychosis ◽

Adult Attachment Interview ◽

First Episode ◽

Duration Of Untreated Psychosis ◽

Episode Psychosis ◽

The Relationship

BackgroundIncreasing evidence shows attachment security influences symptom expression and adaptation in people diagnosed with schizophrenia and other psychoses.AimsTo describe the distribution of secure and insecure attachment in a cohort of individuals with first-episode psychosis, and to explore the relationship between attachment security and recovery from positive and negative symptoms in the first 12 months.MethodThe study was a prospective 12-month cohort study. The role of attachment, duration of untreated psychosis (DUP), baseline symptoms and insight in predicting and mediating recovery from symptoms was investigated using multiple regression analysis and path analysis.ResultsOf the 79 participants, 54 completed the Adult Attachment Interview (AAI): 37 (68.5%) were classified as insecure, of which 26 (48.1%) were insecure/dismissing and 11 (20.4%) insecure preoccupied. Both DUP and insight predicted recovery from positive symptoms at 12 months. Attachment security, DUP and insight predicted recovery from negative symptoms at 12 months.ConclusionsAttachment is an important construct contributing to understanding and development of interventions promoting recovery following first-episode psychosis.

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