Effects of short-term coenzyme Q10 supplementation on markers of oxidative stress and inflammation after downhill running in male mountaineers

Aims Physical activity is usually accompanied by free radicals’ production and oxidative stress. Moreover, to prevent adverse effects, coaches and athletes have to use proper supplementation. Therefore, the present study aimed to investigate the effect of short-term coenzyme Q10 supplementation on malondialdehyde and serum catalase enzyme activity following moderate and severe acute resistance training in inactive female students. Methods & Materials In total, 27 female students were randomly divided into three groups; the groups were homogeneous and equal (two groups of resistance training and one control group). The experimental groups were subjected to moderate-intensity acute (70% 1RM) acute and severe acute activity (85% 1RM) and supplemented with coenzyme Q10 (30 mg /d). CAT and MDA were measured in ELISA using a human kit. Findings Moderate and severe acute resistance activities did not alter MDA and catalytic activity (P>0.05); however, after 2 weeks of coenzyme Q10 supplementation, those resulted in a significant decrease in MDA (0.006 and 0.01, respectively) and CAT (0.04 and 0.007, respectively). There were no significant differences between the effects of two exercises (P>0.05). Conclusion Short-term (two weeks) supplementation of coenzyme Q10 and severe acute resistance activity could reduce two important oxidative stress indexes (MDA and CAT).

Download Full-text

Effect of Coenzyme Q10 Supplementation on Markers of Oxidative Stress in Streptozotocin Induced Diabetic Rats

Journal of Applied Pharmaceutical Science ◽

10.7324/japs.2014.40602 ◽

2014 ◽

pp. 009-015 ◽

Cited By ~ 1

Author(s):

Mona Anwar ◽

Mehrevan Abd El-Moniem ◽

Hoda A Megahed ◽

Safinaz E EL-Toukhy ◽

Nadia A Mohammed ◽

...

Keyword(s):

Oxidative Stress ◽

Coenzyme Q10 ◽

Diabetic Rats ◽

Markers Of Oxidative Stress ◽

Coenzyme Q10 Supplementation

Download Full-text

Effects of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in glazers with occupational cadmium exposure: A randomized, double-blind, placebo-controlled crossover clinical trial

Toxicology and Industrial Health ◽

10.1177/0748233718809256 ◽

2018 ◽

Vol 35 (1) ◽

pp. 32-42 ◽

Cited By ~ 1

Author(s):

Maryam Hormozi ◽

Ramazan Mirzaei ◽

Alireza Nakhaee ◽

Abolfazl payandeh ◽

Shahrokh Izadi ◽

...

Keyword(s):

Oxidative Stress ◽

Clinical Trial ◽

Antioxidant Enzymes ◽

Coenzyme Q10 ◽

Dietary Intervention ◽

Oxidative Stress Marker ◽

Double Blind ◽

Double Blind Placebo ◽

Enzymes Activity ◽

Coenzyme Q10 Supplementation

Recently, there is a growing interest for the use of antioxidants as a preventive agent against cadmium (Cd) intoxication. The current study aimed to investigate the effects of dietary coenzyme Q10 supplementation on oxidative stress and antioxidant enzymes activity in Cd-exposed glazers. In a randomized, double-blind, placebo-controlled 2-month crossover clinical trial, coenzyme Q10 (60 mg twice daily) or placebo was administrated to 40 male glazers occupationally exposed to Cd. The subjects were randomly assigned to the placebo and coenzyme Q10 groups ( n = 20 in each group). Total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) as well as malondialdehyde (MDA) in the serum of glazers were measured at baseline and at the end of both intervention phases. The primary outcomes were the changes in serum levels of MDA, TAC and the activities of SOD, CAT, and GPx during administration with coenzyme Q10 versus placebo. Compared with placebo, treatment to coenzyme Q10 was associated with a significant reduction in serum MDA levels ( p < 0.001) While, there was no significant effect on the serum TAC levels ( p = 0.096). Also, the activity antioxidant enzymes of SOD ( p < 0.001) and GPx ( p = 0.003) were significantly higher and the CAT activity ( p < 0.001) was lower after 2-month coenzyme Q10 administration compared with placebo. Data demonstrated that coenzyme Q10 supplementation at a dose of 60 mg (twice daily) is effective in reducing oxidative stress marker level (MDA) and improving antioxidant enzymes activity in glazers exposed to Cd. However, further research is needed to assess coenzyme Q10 as a possible dietary intervention in Cd-exposed workers. Trial Registration: Iranian Registry of Clinical Trials Registration Number: IRCT2016061228407N1 ( www.who.int/ictrp/network/irct/en/ ).

Download Full-text

THU0305 Effect of Oral Coenzyme Q10 Supplementation on Clinical Symptoms and Oxidative Stress in Fibromyalgia Patients: A Randomized Trial

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.2611 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 288.3-289 ◽

Cited By ~ 2

Author(s):

A. Abou-Raya ◽

S. Abou-Raya ◽

M. Helmii

Keyword(s):

Oxidative Stress ◽

Randomized Trial ◽

Coenzyme Q10 ◽

Clinical Symptoms ◽

Coenzyme Q10 Supplementation ◽

And Oxidative Stress

Download Full-text

Antioxidant cosupplementation therapy with vitamin C, vitamin E, and coenzyme Q10 in patients with oligoasthenozoospermia

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2014.1.1 ◽

2014 ◽

Vol 86 (1) ◽

pp. 1 ◽

Cited By ~ 23

Author(s):

Yoshitomo Kobori ◽

Shigeyuki Ota ◽

Ryo Sato ◽

Hiroshi Yagi ◽

Shigehiro Soh ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Vitamin C ◽

Coenzyme Q10 ◽

Cell Structure ◽

Sperm Concentration ◽

Semen Parameters ◽

Coenzyme Q10 Supplementation ◽

Therapy Treatment

Objective: Overproduction of reactive oxygen species results in oxidative stress, a deleterious process that damages cell structure as well as lipids, proteins, and DNA. Oxidative stress plays a major role in various human diseases, such as oligoasthenozoospermia syndrome. Materials and methods: We evaluated the effectiveness of antioxidant co-supplementation therapy using vitamin C, vitamin E, and coenzyme Q10 in men with oligoasthenozoospermia. Overall, 169 infertile men with oligoasthenozoospermia received antioxidant therapy with 80 mg/day vitamin C, 40 mg/day vitamin E, and 120 mg/day coenzyme Q10. We evaluated spermiogram parameters at baseline and at 3 and 6 months of follow-up. Results: Significant improvements were evident in sperm concentration and motility following coenzyme Q10 therapy. Treatment resulted in 48 (28.4%) partner pregnancies, of which 16 (9.5%) were spontaneous. Significant improvements in sperm cell concentration and sperm motility were observed after 3 and 6 months of treatment. Conclusions: Vitamin C, vitamin E, and coenzyme Q10 supplementation resulted in a significant improvement in certain semen parameters. However, further studies are needed to empirically determine the effect of supplementation on pregnancy rate.

Download Full-text