Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial

Andrologia ◽  
2013 ◽  
Vol 46 (2) ◽  
pp. 177-183 ◽  
Author(s):  
A. Nadjarzadeh ◽  
F. Shidfar ◽  
N. Amirjannati ◽  
M. R. Vafa ◽  
S. A. Motevalian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Antioxidant Enzymes ◽  
Seminal Plasma ◽  
Coenzyme Q10 ◽  
Randomised Clinical Trial ◽  
Double Blind ◽  
Enzymes Activity ◽  
Coenzyme Q10 Supplementation ◽  
And Oxidative Stress

scholarly journals Effects of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in glazers with occupational cadmium exposure: A randomized, double-blind, placebo-controlled crossover clinical trial

2018 ◽  
Vol 35 (1) ◽  
pp. 32-42 ◽  
Author(s):  
Maryam Hormozi ◽  
Ramazan Mirzaei ◽  
Alireza Nakhaee ◽  
Abolfazl payandeh ◽  
Shahrokh Izadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Antioxidant Enzymes ◽  
Coenzyme Q10 ◽  
Dietary Intervention ◽  
Oxidative Stress Marker ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Enzymes Activity ◽  
Coenzyme Q10 Supplementation

Recently, there is a growing interest for the use of antioxidants as a preventive agent against cadmium (Cd) intoxication. The current study aimed to investigate the effects of dietary coenzyme Q10 supplementation on oxidative stress and antioxidant enzymes activity in Cd-exposed glazers. In a randomized, double-blind, placebo-controlled 2-month crossover clinical trial, coenzyme Q10 (60 mg twice daily) or placebo was administrated to 40 male glazers occupationally exposed to Cd. The subjects were randomly assigned to the placebo and coenzyme Q10 groups ( n = 20 in each group). Total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) as well as malondialdehyde (MDA) in the serum of glazers were measured at baseline and at the end of both intervention phases. The primary outcomes were the changes in serum levels of MDA, TAC and the activities of SOD, CAT, and GPx during administration with coenzyme Q10 versus placebo. Compared with placebo, treatment to coenzyme Q10 was associated with a significant reduction in serum MDA levels ( p < 0.001) While, there was no significant effect on the serum TAC levels ( p = 0.096). Also, the activity antioxidant enzymes of SOD ( p < 0.001) and GPx ( p = 0.003) were significantly higher and the CAT activity ( p < 0.001) was lower after 2-month coenzyme Q10 administration compared with placebo. Data demonstrated that coenzyme Q10 supplementation at a dose of 60 mg (twice daily) is effective in reducing oxidative stress marker level (MDA) and improving antioxidant enzymes activity in glazers exposed to Cd. However, further research is needed to assess coenzyme Q10 as a possible dietary intervention in Cd-exposed workers. Trial Registration: Iranian Registry of Clinical Trials Registration Number: IRCT2016061228407N1 ( www.who.int/ictrp/network/irct/en/ ).

scholarly journals Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2021 ◽  
Vol Volume 14 ◽  
pp. 525-534
Author(s):  
Laine de Carvalho Guerra Pessoa Mamede ◽  
Rafaela Lira Formiga Cavalcanti de Lima ◽  
Alexandre Sérgio Silva ◽  
João Carlos Lima Rodrigues Pita ◽  
Nadjeanny Ingrid Galdino Gomes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Vitamin D3 ◽  
Controlled Clinical Trial ◽  
Oxidative Stress Markers ◽  
Obese Women ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals Evaluation of the Effects ofVaccinium arctostaphylosL. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Rasool Soltani ◽  
Mustafa Hakimi ◽  
Sedigheh Asgary ◽  
Syed Mustafa Ghanadian ◽  
Mahtab Keshvari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Serum Levels ◽  
Adult Patients ◽  
Controlled Clinical Trial ◽  
Fruit Extract ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Hs Crp ◽  
And Oxidative Stress

Background.Dyslipidemia produces atherosclerosis, which in turn results in coronary artery disease (CAD). Atherosclerosis is being considered as an inflammatory disease.Vaccinium arctostaphylosL. is a plant with fruits rich in anthocyanins. The aim of this study was to evaluate the effects of fruit extract of this plant on serum levels of lipids, hs-CRP, and malondialdehyde (MDA) as a marker of oxidative stress, in hyperlipidemic adult patients.Methods.In this randomized, double-blind, placebo-controlled clinical trial, 50 hyperlipidemic adult patients were randomly and equally assigned to receive either medicinal (V. arctostaphylosfruit extract) or placebo capsules twice daily for 4 weeks. Each medicinal capsule contained 45 ± 2 mg of anthocyanins. Fasting serum levels of total cholesterol, TG, LDL-C, HDL-C, hs-CRP, and MDA were obtained before and after the intervention and compared.Results. V. arctostaphylosfruit extract significantly reduced total cholesterol (P<0.001), LDL-C (P=0.004), TG (P<0.001), and MDA (P=0.013) compared to placebo but did not have any significant effect on HDL-C (P=0.631) and hs-CRP (P=0.190).Conclusion.Fruit extract ofVaccinium arctostaphyloshas beneficial effects on serum lipid profile and oxidative stress in hyperlipidemic adult patients. Therefore, it could be considered as a supplement for treatment of dyslipidemia and prevention of atherosclerosis development.

scholarly journals Effect of 2-weeks Coenzyme Q10 Supplementation on Malondialdehyde and Catalase Serum Levels Following Moderate and Severe Acute Resistance Training in Inactive Female Students

2019 ◽  
Vol 25 (4) ◽  
pp. 256-269
Author(s):  
Yeganeh Feizi ◽  
◽  
Mohammad Esmaeil Afzalpur ◽  
Seyed-Hosein Abtahi-Eivary ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Resistance Training ◽  
Coenzyme Q10 ◽  
Serum Levels ◽  
Female Students ◽  
Moderate Intensity ◽  
Control Group ◽  
Short Term ◽  
Coenzyme Q10 Supplementation ◽  
And Oxidative Stress

Aims Physical activity is usually accompanied by free radicals’ production and oxidative stress. Moreover, to prevent adverse effects, coaches and athletes have to use proper supplementation. Therefore, the present study aimed to investigate the effect of short-term coenzyme Q10 supplementation on malondialdehyde and serum catalase enzyme activity following moderate and severe acute resistance training in inactive female students. Methods & Materials In total, 27 female students were randomly divided into three groups; the groups were homogeneous and equal (two groups of resistance training and one control group). The experimental groups were subjected to moderate-intensity acute (70% 1RM) acute and severe acute activity (85% 1RM) and supplemented with coenzyme Q10 (30 mg /d). CAT and MDA were measured in ELISA using a human kit. Findings Moderate and severe acute resistance activities did not alter MDA and catalytic activity (P>0.05); however, after 2 weeks of coenzyme Q10 supplementation, those resulted in a significant decrease in MDA (0.006 and 0.01, respectively) and CAT (0.04 and 0.007, respectively). There were no significant differences between the effects of two exercises (P>0.05). Conclusion Short-term (two weeks) supplementation of coenzyme Q10 and severe acute resistance activity could reduce two important oxidative stress indexes (MDA and CAT).

scholarly journals Nutraceutical Improves Glycemic Control, Insulin Sensitivity, and Oxidative Stress in Hyperglycemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2020 ◽  
Vol 15 (4) ◽  
pp. 1934578X2091868
Author(s):  
Akkarach Bumrungpert ◽  
Patcharanee Pavadhgul ◽  
Rewadee Chongsuwat ◽  
Surat Komindr
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Clinical Trial ◽  
Glycemic Control ◽  
Lipid Profiles ◽  
Oxidative Stress Markers ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Stress Markers ◽  
And Oxidative Stress

The aim of this research was to investigate the effects of nutraceuticals including bitter melon, fenugreek, cinnamon, alpha-lipoic acid, zinc, biotin, chromium, and cholecalciferol on glycemic control, insulin sensitivity, lipid profiles, oxidative stress, and inflammatory markers in hyperglycemia. The study design was a randomized, double-blind, placebo-controlled trial. Subjects with hyperglycemia were randomly divided into 2 groups. The treatment group ( n = 52) was given a nutraceutical and the control group ( n = 50) was provided with a placebo for 12 weeks. Fasting blood glucose (FBG), hemoglobin A1c (HbA1C), homeostatic model assessment of insulin resistance (HOMA-IR), lipid profiles, biomarkers of oxidative stress, and inflammation were assessed before and after the intervention at 6 weeks and 12 weeks. Nutraceutical supplementation demonstrated a statistically significant decrease in FBG (13.4% and 18.9%), HbA1C (6.5% and 11.3%), and HOMA-IR (28.9% and 35.2%) compared with the placebo. Moreover, low-density lipoprotein-cholesterol (LDL-C) level was significantly reduced in the nutraceutical group (7.1% and 9.3%). Furthermore, the nutraceutical significantly decreased oxidative stress markers, oxidized LDL-C (14.8% and 18.9%) and malondialdehyde (16.6% and 26.2%) compared with the placebo. In conclusion, this nutraceutical can improve glycemic control, insulin resistance, lipid profiles, and oxidative stress markers in hyperglycemic subjects. Therefore, it has the potential to decrease cardiovascular disease risk factors. Clinical trial registration: TCTR20180907001, www.clinicaltrials.in.th.

Sign in / Sign up

Export Citation Format

Share Document