Home-based and personalized endurance training program for patients with mild to moderate hemophilia A: What can be expected?

The objective of this study was to test the hypothesis that an endurance training program designed to produce recruitment of all extensor muscle fiber types during each exercise bout would stimulate capillary angiogenesis throughout rat gastrocnemius and soleus muscles. Male Sprague-Dawley rats were exercise trained 5 days/wk for 12–14 wk with exercise bouts consisting of a combination of high intensity (32 m/min on a 15% incline) and long duration (90 min/day). On completion of high-intensity endurance training (HIET) or cage activity [sedentary (Sed)], rat hindquarters were vascularly isolated and perfusion fixed with a modified Karnovsky's fixative. Capillary supply was measured in soleus and gastrocnemius muscles by using Olympus Cue 2 image-analyzer software. Capillary supply was reflected in measurements of capillary-to-fiber ratio, capillary numerical density, capillary surface area density, and capillary volume density on transversely cut tissue sections. HIET increased citrate synthase activity by 20 and 42% in the medial and long heads of the triceps brachii, respectively. Sarcomere lengths were similar in gastrocnemius and soleus muscles of Sed and HIET rats after fixation. All four indexes of capillary supply were significantly greater throughout the gastrocnemius muscle of HIET rats compared with Sed values. The relative increase in capillarity was greater in white than in red gastrocnemius muscle of HIET rats. HIET also increased capillary supply of soleus muscle. However, only capillary numerical density was statistically greater (19%) in HIET soleus compared with Sed. These results support the hypothesis that this training program would produce an increase in capillary supply in all extensor muscles.

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Effectiveness of home-based cognitive training program on a cognitive level, the activity of daily living among elderly persons with mild cognitive impairment in selected community settings of Puducherry

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i4.3149 ◽

2020 ◽

Vol 11 (4) ◽

pp. 5301-5309

Author(s):

Govindakumari R ◽

Vijayalakshmi ◽

Sai Sailesh Kumar Goothy ◽

Vijay Raghvan

Keyword(s):

Training Program ◽

Cognitive Training ◽

Structural Changes ◽

The Elderly ◽

Elderly Persons ◽

Community Settings ◽

Daily Life Activities ◽

Home Based ◽

Study Results ◽

The Brain

Aging is a physiological process that leads to both biological and psychological changes. The brain undergoes structural changes as a part of aging. According to the investigator's best knowledge and based on the extensive review, no structured study was conducted in India to test the effectiveness of cognitive training program. Hence, the present study was conducted to test the effectiveness of a home-based training program on select outcomes. A total of 314 elderly participants were recruited for the study after obtaining the written informed consent. After recruiting, the participants were randomly grouped into two groups, that is control and intervention groups, with 157 participants in each group. The intervention was administered to the experimental group. The present study results suggest that the home-based cognitive training program is effective in improving cognitive functions and daily life activities. The study recommends further detailed and multi-centered studies in this area to recommend the implementation of the program in the management of the cognitive impairments of the elderly.

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The effect of 8 weeks endurance exercise on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in skeletal muscle FHL of rats with type 2 diabetes

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v26i12.663 ◽

2019 ◽

Author(s):

Saeedeh Shadmehri ◽

Mohammad Sherafati Moghadam ◽

Farhad Daryanoosh ◽

Shiva Jahani Golbar ◽

Nader Tanideh

Keyword(s):

Type 2 Diabetes ◽

Skeletal Muscle ◽

Protein Synthesis ◽

Training Program ◽

Endurance Training ◽

Endurance Exercise ◽

Training Group ◽

Control Group ◽

Total P

Introduction: The mTOR pathway in skeletal muscle plays a very important role in the protein synthesis process, which plays a very important role in proteins. The role of endurance exercise has not yet been studied in this important pathway in protein synthesis in people with type 2 diabetes. The purpose of the present study was to investigate the effect of 8 weeks endurance training on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in skeletal muscle FHL of rats with type 2 diabetes. Methods: In this experimental study, 16 Sprague-Dawely male rats with average weight of 270±20 were selected and randomly divided into two groups: control (n=8) and endurance training (n=8). The training group exercised according to the training program 4 days a week for 8 weeks. While the control group had no training program. T-test and SPSS V-19 were used to analyze the data. Results: There was not observed any significant difference in the content of total (P=0.58) and phosphorylated (P=0.33) AKT1, total (P=0.47) and phosphorylated (P=0.78) mTOR, total (P=0.24) and phosphorylated (P=0.12) P70S6K1 and total (P=0.45) and phosphorylated (P=0.48) 4E-BP1 proteins in the endurance training group compared to the control group. Conclusion: Endurance training for 8 weeks could not increase the total and phosphorylated content proteins of the present study; therefore, it cannot lead to protein synthesis or muscle hypertrophy through mTORC1 pathway.

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Comparison of the Effects of a Home-Based and Group-Based Resistance Training Program on Functional Ability in Older Adults

American Journal of Health Promotion ◽

10.4278/ajhp.07030120 ◽

2008 ◽

Vol 23 (1) ◽

pp. 13-17 ◽

Cited By ~ 24

Author(s):

Elizabeth V. Cyarto ◽

Wendy J. Brown ◽

Alison L. Marshall ◽

Stewart G. Trost

Keyword(s):

Older Adults ◽

Resistance Training ◽

Training Program ◽

Functional Ability ◽

Resistance Training Program ◽

Home Based

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Efficacy of an 8-Week Concurrent Strength and Endurance Training program on Hand Cycling Performance

The Journal of Strength and Conditioning Research ◽

10.1519/jsc.0000000000002569 ◽

2018 ◽

Vol 32 (7) ◽

pp. 1861-1868 ◽

Cited By ~ 6

Author(s):

Jonpaul Nevin ◽

Paul Smith ◽

Mark Waldron ◽

Stephen Patterson ◽

Mike Price ◽

...

Keyword(s):

Training Program ◽

Endurance Training ◽

Cycling Performance ◽

Hand Cycling

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Effectiveness of a Home Based Training Program on Caregivers Knowledge in Managing Aggressive Behavior of Patients With Mental Illness

Home Health Care Management & Practice ◽

10.1177/10848223211039448 ◽

2021 ◽

pp. 108482232110394

Author(s):

Kusum Lata ◽

T. K Ajesh Kumar ◽

Deepika C. Khakha ◽

Raman Deep

Keyword(s):

Mental Illness ◽

Aggressive Behavior ◽

Training Program ◽

Mentally Ill ◽

Warning Signs ◽

Caregiver Training ◽

Bonferroni Adjustment ◽

Home Based ◽

Post Test ◽

At Home

In India, more than 90% of the patient with chronic mental illness stayed with their family members. Approximately 77.4% of caregivers experience moderate to severe levels of aggression. The purpose of this study was to evaluate the effectiveness of caregiver-training program on knowledge in managing aggressive behavior of mentally ill at home. Research design was pre-experimental. Seventy two caregivers were recruited using purposive sampling technique. The caregivers knowledge was assessed at 3 time points with regard to training program; before, immediately (post-test 1), and after 1 month (±1 week; post-test 2). The baseline knowledge was reflective of the deficiencies existing in the management of aggression of the mentally ill by caregivers. The knowledge of caregivers regarding the management of aggressive behavior of mentally ill, increased after caregiver training program, from the pre-test score of 17.63 ± 3.3 to post-test 1 score of 23.26 ± 2.9, and slightly decreased post-test 2 score of 21.01 ± 3.3 at p < .05. Repeated measure analysis of variance (ANOVA) was done to compare the differences in knowledge score over time with Bonferroni adjustment. This home based caregiver training program helped caregivers to identify etiological factors of aggression, warning signs of aggression and use of de-escalation strategies to manage aggressive behavior of mentally ill. Training caregivers regarding aggression management will make caregiver proficient in practicing safe approach during handling of aggressive patient which will ensure the physical safety of the caregiver as well as of the patient and let the patient stay at home.

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