Clinical features of methotrexate osteopathy in rheumatic musculoskeletal disease: a systematic review

Abstract Background Few studies have focused on exploring the clinical characteristics and outcomes of COVID-19 in older patients. We conducted this systematic review and meta-analysis to have a better understanding of the clinical characteristics of older COVID-19 patients. Methods A systematic search of PubMed and Scopus was performed from December 2019 to May 3rd, 2020. Observational studies including older adults (age ≥ 60 years) with COVID-19 infection and reporting clinical characteristics or outcome were included. Primary outcome was assessing weighted pooled prevalence (WPP) of severity and outcomes. Secondary outcomes were clinical features including comorbidities and need of respiratory support. Result Forty-six studies with 13,624 older patients were included. Severe infection was seen in 51% (95% CI– 36-65%, I2–95%) patients while 22% (95% CI– 16-28%, I2–88%) were critically ill. Overall, 11% (95% CI– 5-21%, I2–98%) patients died. The common comorbidities were hypertension (48, 95% CI– 36-60% I2–92%), diabetes mellitus (22, 95% CI– 13-32%, I2–86%) and cardiovascular disease (19, 95% CI – 11-28%, I2–85%). Common symptoms were fever (83, 95% CI– 66-97%, I2–91%), cough (60, 95% CI– 50-70%, I2–71%) and dyspnoea (42, 95% CI– 19-67%, I2–94%). Overall, 84% (95% CI– 60-100%, I2–81%) required oxygen support and 21% (95% CI– 0-49%, I2–91%) required mechanical ventilation. Majority of studies had medium to high risk of bias and overall quality of evidence was low for all outcomes. Conclusion Approximately half of older patients with COVID-19 have severe infection, one in five are critically ill and one in ten die. More high-quality evidence is needed to study outcomes in this vulnerable patient population and factors affecting these outcomes.

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Risk Factors, and Clinical and Etiological Characteristics of Ischemic Strokes in COVID-19-Infected Patients: A Systematic Review of Literature

Cerebrovascular Diseases ◽

10.1159/000514267 ◽

2021 ◽

pp. 1-4

Author(s):

Simone Vidale

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Clinical Features ◽

Case Reports ◽

Clinical Severity ◽

Large Artery ◽

Causal Association ◽

Review Of Literature ◽

Increased Risk ◽

Long Time

Background and Purpose: Coronavirus disease 2019 (COVID-19) infection is an ongoing pandemic and worldwide health emergency that has caused important changes in healthcare systems. Previous studies reported an increased risk of thromboembolic events, including stroke. This systematic review aims to describe the clinical features and etiological characteristics of ischemic stroke patients with COVID-19 infection. Method: A literature search was performed in principal databases for studies and case reports containing data concerning risk factors, clinical features, and etiological characteristics of patients infected with COVID-19 and suffering from stroke. Descriptive and analytical statistics were applied. Results: Overall, 14 articles were included for a total of 93 patients. Median age was 65 (IQR: 55–75) years with prevalence in males. Stroke occurred after a median of 6 days from COVID-19 infection diagnosis. Median National of Institute of Health Stroke Scale (NIHSS) score was 19. Cryptogenic (Cry) strokes were more frequent (51.8%), followed by cardioembolic etiology, and they occurred a long time after COVID-19 diagnosis compared with large-artery atherosclerosis strokes (ptrend: 0.03). The clinical severity of stroke was significantly associated with the severity grade of COVID-19 infection (ptrend: 0.03). Conclusions: Ischemic strokes in COVID-19-infected patients were clinically severe, affecting younger patients mainly with Cry and cardioembolic etiologies. Further multicenter prospective registries are needed to better describe the causal association and the effect of COVID-19 infection on stroke.

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Primary and radiation induced skull base osteosarcoma: a systematic review of clinical features and treatment outcomes

Journal of Neuro-Oncology ◽

10.1007/s11060-021-03757-z ◽

2021 ◽

Author(s):

Othman Bin Alamer ◽

Ali S. Haider ◽

Maryam Haider ◽

Navraj S. Sagoo ◽

Faith C. Robertson ◽

...

Keyword(s):

Systematic Review ◽

Skull Base ◽

Treatment Outcomes ◽

Clinical Features ◽

Radiation Induced

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Clinical features and treatment strategy of paraspinal arteriovenous shunt (PAVS): a systematic review with individual participants data meta-analysis

European Spine Journal ◽

10.1007/s00586-021-06831-2 ◽

2021 ◽

Author(s):

Jang Hun Kim ◽

Sang Hoon Yoon ◽

Suhk Que Park ◽

Seung-Pil Ban ◽

Byung-Kyu Cho

Keyword(s):

Systematic Review ◽

Clinical Features ◽

Treatment Strategy ◽

Meta Analysis ◽

Arteriovenous Shunt

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Clinical Features, Natural History and Outcomes of Intraneural Perineuriomas: A Systematic Review of the Literature

World Neurosurgery ◽

10.1016/j.wneu.2021.07.042 ◽

2021 ◽

Author(s):

Karina A. Lenartowicz ◽

Anshit Goyal ◽

Michelle L. Mauermann ◽

Thomas J. Wilson ◽

Robert J. Spinner

Keyword(s):

Systematic Review ◽

Natural History ◽

Clinical Features ◽

Review Of The Literature

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COVID-19 in pregnancy: a systematic review of chest CT findings and associated clinical features in 427 patients

Clinical Imaging ◽

10.1016/j.clinimag.2021.01.004 ◽

2021 ◽

Vol 75 ◽

pp. 75-82

Author(s):

Rachel R. Oshay ◽

Michael Y.C. Chen ◽

Brandon K.K. Fields ◽

Natalie L. Demirjian ◽

Ryan S. Lee ◽

...

Keyword(s):

Systematic Review ◽

Clinical Features ◽

Chest Ct ◽

Ct Findings ◽

In Pregnancy

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Epidemiology and clinical features of COVID-19 outbreaks in aged care facilities: A systematic review and meta-analysis

EClinicalMedicine ◽

10.1016/j.eclinm.2021.100771 ◽

2021 ◽

Vol 33 ◽

pp. 100771 ◽

Cited By ~ 1

Author(s):

Mohammad Rashidul Hashan ◽

Nicolas Smoll ◽

Catherine King ◽

Hannah Ockenden-Muldoon ◽

Jacina Walker ◽

...

Keyword(s):

Systematic Review ◽

Clinical Features ◽

Meta Analysis ◽

Aged Care ◽

Care Facilities ◽

Aged Care Facilities

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Clinical Features, Diagnosis and Treatment Outcome of Fungal Endocarditis: A Systematic Review of Reported Cases

Mycoses ◽

10.1111/myc.13398 ◽

2021 ◽

Author(s):

Durga Shankar Meena ◽

Deepak Kumar ◽

Madhulata Agarwal ◽

Gopal Krishana Bohra ◽

Rahul Choudhary ◽

...

Keyword(s):

Systematic Review ◽

Treatment Outcome ◽

Clinical Features ◽

Diagnosis And Treatment ◽

Fungal Endocarditis

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Indian scenario of IgA nephropathy: a systematic review and meta-analysis

African Health Sciences ◽

10.4314/ahs.v21i1.21 ◽

2021 ◽

Vol 21 (1) ◽

pp. 159-65

Author(s):

Anju Khairwa

Keyword(s):

Systematic Review ◽

Iga Nephropathy ◽

Clinical Features ◽

Meta Analysis ◽

Microscopic Hematuria ◽

Macroscopic Hematuria ◽

Female Ratio ◽

Cochrane Database ◽

Male Female Ratio ◽

Indian Scenario

Background: IgA nephropathy (IgAN) is most common primary glomerulopathy. There are variations in prevalence of IgAN and its clinical features in different studies from India. Aim: To summarize overall scenario of IgAN in India. Methods: In this systematic review, studies related to IgAN and related renal disease were included. Data searched were PubMed, EMBASE, Google scholar, and Cochrane Database from inception to 31st January 2019. Results: Total 49 studies (N=2480) were included: 21studies (N=2309) of primary IgAN; 19 studies (N=21) of Secondary IgAN; four studies (N=133) of IgA vasculitis nephropathy (IgAVN); and five studies (N=17) of IgA dominant nephropathy (IgADN). Prevalence of IgAN was 16.5% in India. Age of affected persons was ranging from 27.2±16.7 to 48.6±21.3 years . Male female ratio was 1.8:1. Clinical features of Primary IgAN, IgAVN, IgADN & Secondary IgAN were microscopic hematuria (49.6%, 44.4%, 15.6% & 59.5%), macroscopic hematuria (5.1%, 0.4%,40.9%,& 35.7%), Subnephrotic proteinuria (42.1%, 29.4%, 23.2%, & 52.3%), nephrotic proteinuria (16.0%, 4.4%, 76.8%,& 47.6%), and hypertension (25.8%,18.3%, 35.5%,& 47.6%).. The 24 hours proteinuria was ranging from 2.6±1.5 to 4.7±2.3 gm/day and serum creatinine (mg/dl) was ranging from 0.9±0 to 3.5±3.9 mg/dl. Histolomorphologically, all type of IgAN showed mesangial hypercellularity and Immunofluorescence revealed IgA deposition. Conclusion: The overall prevalence of primary IgAN in India was 16.5%. The subnephrotic proteinuria and microscopic hematuria were common clinical features. Keywords: IgA Nephropathy; histomorphology; prevalence; India.

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