Modeling and simulation of drug delivery from a new type of biodegradable polymer micro-device

2007 ◽  
Vol 133 (2) ◽  
pp. 363-367 ◽  
Author(s):  
Xiao-Peng Wang ◽  
Tian-Ning Chen ◽  
Zhan-Xiao Yang
Keyword(s):  
Drug Delivery ◽  
Modeling And Simulation ◽  
Biodegradable Polymer ◽  
New Type

Pharmacokinetic Modeling in Nano-formulations: Concept, Implementation and Challenges

2019 ◽  
Vol 24 (43) ◽  
pp. 5175-5180 ◽  
Author(s):  
Jatinder Kaur Mukker ◽  
Ravi Shankar Prasad Singh
Keyword(s):  
Drug Delivery ◽  
Modeling And Simulation ◽  
Small Molecules ◽  
Pharmacokinetic Modeling ◽  
Simulation Techniques ◽  
Modeling Techniques

The properties of nanoparticles can be exploited to overcome challenges in drug delivery. By virtue of its design and size, the pharmacokinetics of nanoparticles are different than other small molecules. Modeling and simulation techniques have great potential to be used in nanoformulation development; however, their use in optimization of nanoformulation is very limited. This review highlights the differences in absorption, distribution, metabolism and excretion (ADME) characteristics of nanoparticles, use of modeling and simulation techniques in nanoformulation development and challenges in the implementation of modeling techniques.

The Research and Simulation Analysis of a New Type of Translational Transmission Device

2014 ◽  
Vol 556-562 ◽  
pp. 1408-1412
Author(s):  
Zhi Qiang Zhang
Keyword(s):  
Modeling And Simulation ◽  
Theoretical Foundation ◽  
Simulation Analysis ◽  
Structural Modeling ◽  
Structural Features ◽  
Practical Application ◽  
Optimization Analysis ◽  
New Type ◽  
Mechanism Parameter ◽  
Relationship Of

In this paper, the following work is done: a new type of translational transmission device is designed; explained in detail are the operating principle, structural features, relationship of mechanism parameter and non interference conditions of the movement; the optimization analysis of transmission device is implemented on the basis of non interference conditions of the bucket movement; structural modeling and simulation analysis are carried out by utilization of Pro/e & Recurdyn; and based on virtual prototype technology, the new type of translational transmission device is verified by experiments, the data of which prove the translational transmission device reasonable and practicable. In conclusion, this paper has laid the theoretical foundation of the practical application of the translational transmission device.

scholarly journals Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition

2016 ◽  
Vol 4 (29) ◽  
pp. 5035-5045 ◽  
Author(s):  
Qiang Chen ◽  
Wei Li ◽  
Qingqing Yao ◽  
Ruifang Liang ◽  
Rosalina Pérez-Garcia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Matrix ◽  
Electrophoretic Deposition ◽  
Biodegradable Polymer ◽  
Drug Encapsulation

Drug encapsulation with predetermined loading, and the fabrication of multilayered drug delivery coatings by a combination of EPD and LbL deposition.

Processing of Biodegradable Polymer Composites as A Drug Delivery System in Vitro

1999 ◽  
Vol 14 (4) ◽  
pp. 322-325
Author(s):  
S.-J. Liu ◽  
C.-H. Tsai ◽  
S.-S. Lin ◽  
S. W.-N. Ueng
Keyword(s):  
Drug Delivery ◽  
Polymer Composites ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biodegradable Polymer

scholarly journals Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

2021 ◽  
Author(s):  
Shishuai Dang ◽  
Zhengwei Huang ◽  
Ying Huang ◽  
Xin Pan ◽  
Chuanbin Wu
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Beclomethasone Dipropionate ◽  
Drug Loading ◽  
Pulmonary Delivery ◽  
Dynamics Simulation ◽  
Loading Capacity ◽  
Technology Platform ◽  
New Type ◽  
Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

A pH-responsive amphiphilic chitosan–pyranine core–shell nanoparticle for controlled drug delivery, imaging and intracellular pH measurement

2014 ◽  
Vol 2 (38) ◽  
pp. 6580-6589 ◽  
Author(s):  
Hao-Syun Chou ◽  
Meng-Hsuan Hsiao ◽  
Wei-Yang Hung ◽  
Tin-Yo Yen ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Ph ◽  
Controlled Drug Delivery ◽  
Ph Measurement ◽  
Core Shell ◽  
Ph Responsive ◽  
Cellular Resolution ◽  
New Type

A new type of CHC–PY core–shell nanoparticle provides multiple functionality, where a synergistic performance of nanotherapeutics, imaging and even diagnosis at a cellular resolution can be achieved simultaneously.

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