Linked bridge hybridizing-induced split G-quadruplex DNA machine and its application to uracil-DNA glycosylase detection

2018 ◽  
Vol 255 ◽  
pp. 2589-2594 ◽  
Author(s):  
Xiao Fang Zhang ◽  
Na Li ◽  
Yu Ling ◽  
Li Tang ◽  
Nian Bing Li ◽  
...  
Keyword(s):  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Machine

A label-free fluorescence method for the detection of uracil DNA glycosylase activity based on G-quadruplex formation

2016 ◽  
Vol 8 (41) ◽  
pp. 7453-7459 ◽  
Author(s):  
Changbei Ma ◽  
Kefeng Wu ◽  
Jun Wang ◽  
Hailun He ◽  
Feng Ning ◽  
...  
Keyword(s):  
Fluorescence Method ◽  
Thioflavin T ◽  
Dna Glycosylase ◽  
Label Free ◽  
Uracil Dna Glycosylase ◽  
Label Free Detection ◽  
G Quadruplex ◽  
Quadruplex Formation

A simple fluorescence based biosensor for label-free detection of uracil DNA glycosylase activity based on G-quadruplex formation using a thioflavin T probe is reported.

Label-free fluorescence turn-on detection of uracil DNA glycosylase activity based on G-quadruplex formation

Talanta ◽  
2016 ◽  
Vol 160 ◽  
pp. 449-453 ◽  
Author(s):  
Changbei Ma ◽  
Kefeng Wu ◽  
Haisheng Liu ◽  
Kun Xia ◽  
Kemin Wang ◽  
...  
Keyword(s):  
Dna Glycosylase ◽  
Label Free ◽  
Uracil Dna Glycosylase ◽  
Turn On ◽  
G Quadruplex ◽  
Quadruplex Formation ◽  
Fluorescence Turn On

A colorimetric and smartphone readable method for uracil-DNA glycosylase detection based on the target-triggered formation of G-quadruplex

The Analyst ◽  
2015 ◽  
Vol 140 (8) ◽  
pp. 2771-2777 ◽  
Author(s):  
Huaijun Nie ◽  
Wei Wang ◽  
Wang Li ◽  
Zhou Nie ◽  
Shouzhuo Yao
Keyword(s):  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
G Quadruplex

A simple, colorimetric and smartphone readable method based on the target-triggered formation of G-quadruplex has been developed for uracil-DNA glycosylase detection.

Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

2020 ◽  
Vol 27 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Claudiu N. Lungu ◽  
Bogdan Ionel Bratanovici ◽  
Maria Mirabela Grigore ◽  
Vasilichia Antoci ◽  
Ionel I. Mangalagiu
Keyword(s):  
Experimental Data ◽  
Antimicrobial Properties ◽  
Qsar Model ◽  
Therapeutic Effectiveness ◽  
Computational Results ◽  
Pyridine Derivatives ◽  
Quadruplex Dna ◽  
Dna Intercalators ◽  
Structure Activity ◽  
G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

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