Single-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serum

2020 ◽  
Vol 308 ◽  
pp. 127692 ◽  
Author(s):  
Mengsha Ye ◽  
Mingdi Jiang ◽  
Jing Cheng ◽  
Xuanying Li ◽  
Ziwei Liu ◽  
...  
2021 ◽  
Author(s):  
Sopit Phetsang ◽  
Pinit Kidkhunthod ◽  
Narong Chanlek ◽  
Jaroon Jakmunee ◽  
Pitchaya Mungkornasawakul ◽  
...  

Abstract Numerous studies suggest that modification with functional nanomaterials can enhance the electrode electrocatalytic activity, sensitivity, and selectivity of the electrochemical sensors. Here, a highly sensitive and cost-effective disposable non-enzymatic glucose sensor based on copper(II)/reduced graphene oxide modified screen-printed carbon electrode is demonstrated. Facile fabrication of the developed sensing electrodes is carried out by the adsorption of copper(II) onto graphene oxide modified electrode, then following the electrochemical reduction. The proposed sensor illustrates good electrocatalytic activity toward glucose oxidation with a wide linear detection range from 0.10 mM to 12.5 mM, low detection limit of 65 µM, and high sensitivity of 172 µA mM− 1 cm− 2 along with satisfactory anti-interference ability, reproducibility, stability, and the acceptable recoveries for the detection of glucose in a human serum sample (95.6–106.4%). The copper(II)/reduced graphene oxide based sensor with the superior performances is a great potential for the quantitation of glucose in real samples.


RSC Advances ◽  
2017 ◽  
Vol 7 (52) ◽  
pp. 32749-32756 ◽  
Author(s):  
Huan Yuan ◽  
Xiaosong Du ◽  
Huiling Tai ◽  
Xiao Yang ◽  
Ming Xu

Schematic diagram of single-layer stationary phase film (a) and two-step stationary phase film (b).


RSC Advances ◽  
2016 ◽  
Vol 6 (14) ◽  
pp. 11167-11175 ◽  
Author(s):  
Aixian Zheng ◽  
Da Zhang ◽  
Ming Wu ◽  
Huanghao Yang ◽  
Xiaolong Liu ◽  
...  

Multifunctional human serum albumin-modified reduced graphene oxide can specifically target HCC cells and effectively kill them with the help of a NIR laser.


2016 ◽  
Vol 75 ◽  
pp. 389-395 ◽  
Author(s):  
Lijie He ◽  
Qian Wang ◽  
Daniel Mandler ◽  
Musen Li ◽  
Rabah Boukherroub ◽  
...  

Author(s):  
Medha Gijare ◽  
◽  
Sharmila Chaudhari ◽  
Satish Ekar ◽  
Anil Garje ◽  
...  

2020 ◽  
Vol 12 (8) ◽  
pp. 1125-1136
Author(s):  
Rupali Waichal ◽  
Ashwini Bhirud ◽  
H. Fouad ◽  
Suresh Gosavi ◽  
Muthupandian Ashokkumar

Reduced Graphene oxide (RGO) decorated with Ni nanoparticles (NiNPs) composites, have been successfully synthesized using a simple hydrothermal method and possessing excellent electrocatalytic activity towards glucose oxidation. The morphological and structural features of RGO-Ni nanocomposites were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and energy dispersive spectroscopy (EDS). From TEM, we observed that NiNPs were anchored on RGO sheets. Cyclic Voltammetric (CV) study revealed that the electrocatalytic activity of RGO-Ni nanocomposite with 20% Ni loading (RGONi-20) towards glucose oxidation is better than that shown by bare Glassy Carbon Electrode (GCE), RGO, bare NiNPs, RGONi10 and RGONi-30. The prepared nanocomposites exhibited fast electrocatalytic response (<5 s) towards glucose oxidation. Amperometric study indicates that the present glucose sensor have exhibited excellent performance by offering a lowest detection limit as 5.1 μM, with linier range from 2 to 5000 μM and high sensitivity of 896.67 μA mM–1 cm–2. Interference from different anticipatable electroactive substances such as ascorbic acid (AA), uric acid (UA) and dopamine (DA) is not observed. Furthermore, the application of the as prepared sensor was successfully demonstrated for the detection of glucose in human serum and results were compa- rable to presently used nonenzymatic technique. RGONi-20 nanocomposite electrode holds great promise for the development of biosensors and other electrochemical devices.


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