Rational design of a novel aptamer-based biosensor for a target enzyme via modification of GFP-like fluorogens: Carboxylesterase 2A as a case study

2021 ◽  
Vol 330 ◽  
pp. 129312
Author(s):  
Yue Chen ◽  
Qing-Qing He ◽  
Dan-Dan Wang ◽  
Fang-Yuan Wang ◽  
Xiao-Qing Guan ◽  
...  
Keyword(s):  
Rational Design ◽  
Target Enzyme

Legalization in context: The design of the WTO’s dispute settlement system

2017 ◽  
Vol 19 (2) ◽  
pp. 304-319 ◽  
Author(s):  
Manfred Elsig
Keyword(s):  
Rational Design ◽  
Dispute Settlement ◽  
The United States ◽  
Settlement System ◽  
Trading System ◽  
Wto Dispute Settlement ◽  
Multilateral Trading System ◽  
The Creation ◽  
Dispute Settlement System

This article asks why the dispute settlement provisions of the multilateral trading system underwent significant reforms during the negotiations that led to the creation of the World Trade Organization (WTO) in 1995. Why did the leading trading powers accept a highly legalized system that departed from established political–diplomatic forms of settling disputes? The contribution of this article is threefold. First, it complements existing accounts that exclusively focus on the United States with a novel explanation that takes account of contextual factors. Second, it offers an in-depth empirical case study based on interviews with negotiators who were involved and novel archival evidence on the creation of the new WTO dispute settlement system. Third, by unpacking the long-standing puzzle of why states designed a highly legalized system, it addresses selected blind spots of the legalization and the rational design literatures with the aim of providing a better understanding about potential paths leading toward significant changes in legalization.

scholarly journals Rational Design of Dual Active Sites in a Single Protein Scaffold: A Case Study of Heme Protein in Myoglobin

ChemistryOpen ◽  
2016 ◽  
Vol 5 (3) ◽  
pp. 192-196 ◽  
Author(s):  
Xiao-Gang Shu ◽  
Ji-Hu Su ◽  
Ke-Jie Du ◽  
Yong You ◽  
Shu-Qin Gao ◽  
...  
Keyword(s):  
Active Sites ◽  
Rational Design ◽  
Heme Protein ◽  
Protein Scaffold ◽  
Single Protein

Berichtigung: Target Enzyme‐Activated Two‐Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two‐Dimensional Design Strategy

2019 ◽  
Vol 131 (39) ◽  
pp. 13752-13752
Author(s):  
Jing Ning ◽  
Wei Wang ◽  
Guangbo Ge ◽  
Peng Chu ◽  
Feida Long ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Design Strategy ◽  
Two Dimensional ◽  
Two Photon ◽  
Target Enzyme

Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors

2011 ◽  
Vol 54 (15) ◽  
pp. 5607-5611 ◽  
Author(s):  
Zhijian Xu ◽  
Zheng Liu ◽  
Tong Chen ◽  
TianTian Chen ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Rational Design ◽  
Halogen Bond ◽  
Lead Optimization ◽  
Pde5 Inhibitors ◽  
Phosphodiesterase Type

scholarly journals Guidelines for rational design of high-performance absorbents: A case study of zeolite adsorbents for emerging pollutants in water

2017 ◽  
Vol 2 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Xiaoxuan Wei ◽  
Ya Wang ◽  
Arturo J. Hernández-Maldonado ◽  
Zhongfang Chen
Keyword(s):  
High Performance ◽  
Rational Design ◽  
Emerging Pollutants

In situ target enzyme-activated near-infrared fluorescent probe: A case study of CYP2J2 using three-fragmentary molecular assembly engineering

2021 ◽  
Vol 328 ◽  
pp. 129034 ◽  
Author(s):  
Yanpeng Dai ◽  
Tianzi Xue ◽  
Hefang Ji ◽  
Pan Zhang ◽  
Dongdong Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Molecular Assembly ◽  
Target Enzyme

scholarly journals A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study

2017 ◽  
Vol 8 (4) ◽  
pp. 2795-2803 ◽  
Author(s):  
Zi-Ru Dai ◽  
Lei Feng ◽  
Qiang Jin ◽  
Hailing Cheng ◽  
Yan Li ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Specific Probe ◽  
Practical Strategy ◽  
Target Enzyme

A practical strategy was proposed and successfully used to design and develop an isoform-specific probe for a given enzyme.

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