This chapter looks at the synergistic relationship between the concepts of commissioning and population health gain, and some practical ways to enable this connectivity. In simple terms, commissioning refers to securing services for the population, and a whole population perspective is clearly integral to this effort. This chapter introduces four key perspectives of a population approach that can be applied to any health issue in the commissioning sphere. These are the consideration of Epidemiological context, effective Preventive opportunities, a focus on addressing Inequities in access and outcomes of care, and a whole Care pathway and System perspective. (The acronym ‘EPICS’ can be used to aid recall if needed). Application of these would be underpinned by using an evidence-based approach. Together these summary perspectives offer a quick schema to scope any health topic in practice which can be used as needed for the task in-hand. Examples are given.