Synthesis of new steroidal imidazo [1,2-a] pyridines: DNA binding studies, cleavage activity and in vitro cytotoxicity

Steroids ◽  
2015 ◽  
Vol 104 ◽  
pp. 163-175 ◽  
Author(s):  
Ayaz Mahmood Dar ◽  
Shamsuzzaman ◽  
Manzoor Ahmad Gatoo
Keyword(s):  
Dna Binding ◽  
In Vitro Cytotoxicity ◽  
Binding Studies ◽  
Cleavage Activity ◽  
Dna Binding Studies

Carbohydrate-conjugate heterobimetallic complexes: synthesis, DNA binding studies, artificial nuclease activity and in vitro cytotoxicity

2011 ◽  
Vol 346 (18) ◽  
pp. 2886-2895 ◽  
Author(s):  
Sartaj Tabassum ◽  
Rais Ahmad Khan ◽  
Farukh Arjmand ◽  
Mubashira Aziz ◽  
Aarti S. Juvekar ◽  
...  
Keyword(s):  
Dna Binding ◽  
Nuclease Activity ◽  
In Vitro Cytotoxicity ◽  
Binding Studies ◽  
Heterobimetallic Complexes ◽  
Dna Binding Studies ◽  
Artificial Nuclease

scholarly journals Synthesis and DNA-Binding Studies of a Dinuclear Gadolinium(III)–Platinum(II) Complex

2015 ◽  
Vol 68 (4) ◽  
pp. 576 ◽  
Author(s):  
Jacob M. Fenton ◽  
Madleen Busse ◽  
Louis M. Rendina
Keyword(s):  
Dna Binding ◽  
Linear Dichroism ◽  
Binding Mode ◽  
In Vitro Cytotoxicity ◽  
Binding Studies ◽  
Binding Interaction ◽  
Absorption Region ◽  
Synthetic Strategy ◽  
Dna Binding Studies

The synthesis and characterisation of a new dinuclear GdIII–PtII complex (1·PF6) containing a functionalised macrocyclic 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derivative linked to a PtII-terpy (terpy = 2,2′ : 6′,2″-terpyridine) unit by means of a short thiolato linker are reported. The complex was synthesised in six steps from cyclen by means of a modular synthetic strategy. A preliminary DNA-binding study with calf-thymus DNA (ct-DNA) was performed on 1·PF6 by means of linear dichroism (LD). The observed changes in the DNA LD signal in the presence of the metal complex are fully consistent with an intercalative binding mode. Furthermore, an induced negative LD signal in the ultraviolet absorption region of the complex provides strong evidence of a strong DNA-binding interaction. The in vitro cytotoxicity of 1·PF6 towards a human glioblastoma cell line (T98G) was also determined.

IN VITRO DNA BINDING STUDIES OF SELECTED HETEROCYCLIC COMPOUNDS

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (12) ◽  
pp. 24-26
Author(s):  
C Akhila ◽  
◽  
P Lalitha
Keyword(s):  
Dna Binding ◽  
Heterocyclic Compounds ◽  
Uv Spectroscopy ◽  
Binding Mode ◽  
Spectroscopic Technique ◽  
Binding Studies ◽  
Base Pairs ◽  
Dna Base ◽  
Dna Binding Studies

DNA binding studies of selected heterocyclic compounds belonging to the class of quinolinones, substituted quinolinones and thiones were carried out using ct-DNA. The binding nature of the compounds with DNA analyzed using UV-spectroscopy revealed the compounds to be DNA intercalators demonstrating the binding nature of compounds with DNA base pairs. This study is aimed at establishing a facile UV spectroscopic technique to arrive at the binding mode of DNA to ligands.

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