Preoperative blood transfusion is a predictor of worse short-term postoperative outcomes after colectomy

Objective. To find out the success rate of conservative management of complete two weeks for miscarriage in view of NICE Guideline 154.Design. Prospective observational study.Setting. Early pregnancy assessment units of District General Hospital in the United Kingdom.Participants. Women of less than 14 weeks’ gestation, with a diagnosis of miscarriage (missed miscarriage/anembryonic or incomplete miscarriage).Interventions.Expectant management for two weeks.Main Outcome Measure.(1) Efficacy of 2-week expectant management, that is, complete resolution of miscarriage based either on self-reporting of patient after passing products of conception at home between D0 and D14 of expectant management or confirmation on scan at D14, and (2) short-term complications needing strong analgesia, blood transfusion, and antibiotics.Results. Expectant management of miscarriage for 2 weeks from the day of diagnosis was successful in 58% (64 /111) and failed in 42% (47/111).Conclusions. Expectant management success rate is consistent with the results from the longitudinal studies and RCTs published in the past. It is a safe option as none of the patients on expectant/medical management needed strong analgesia/antibiotics or blood transfusion.

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Does Timing of Robotic Esophagectomy Adoption Impact Short-Term Postoperative Outcomes?

Journal of Surgical Research ◽

10.1016/j.jss.2020.11.077 ◽

2021 ◽

Vol 260 ◽

pp. 220-228

Author(s):

Jonathan J. Hue ◽

Katelynn C. Bachman ◽

Kelsey E. Gray ◽

Philip A. Linden ◽

Stephanie G. Worrell ◽

...

Keyword(s):

Postoperative Outcomes ◽

Short Term ◽

Robotic Esophagectomy

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Short term outcomes associated with patients requiring blood transfusion following elective laminectomy and fusion for lumbar stenosis: A propensity-matched analysis

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2021.05.061 ◽

2021 ◽

Vol 90 ◽

pp. 184-190

Author(s):

Spencer C. Darveau ◽

Nathan J. Pertsch ◽

Steven A. Toms ◽

Robert J. Weil

Keyword(s):

Blood Transfusion ◽

Lumbar Stenosis ◽

Short Term ◽

Laminectomy And Fusion

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Abstract 16074: Risk of Blood Transfusion(s) With New Oral Anticoagulants for Short-Term Thromboprophylaxis in Hip and Knee Surgery: Insights From a Meta-Analysis of Fifteen Randomized Trials Including 36,176 Patients

Circulation ◽

10.1161/circ.130.suppl_2.16074 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Parasuram Krishnamoorthy ◽

Saurav Chatterjee ◽

Jalaj Garg ◽

Partha Sardar ◽

Franz Messerli ◽

...

Keyword(s):

Blood Transfusion ◽

Randomized Controlled Trials ◽

Conventional Therapy ◽

Oral Anticoagulants ◽

Knee Surgery ◽

New Oral Anticoagulants ◽

Controlled Trials ◽

Short Term ◽

Randomized Controlled ◽

Hip And Knee Surgery

Introduction: Blood transfusions have been associated with poor outcomes in cardiac patients. The objective of our study was to systematically examine the overall risk of blood transfusion with new oral anticoagulants (NOACs) and individually in thromboprophylaxis for hip and knee surgery. Hypothesis: Treatment with NOACs is safe for short-term thromboprophylaxis in patients undergoing hip and knee surgery compared with conventional therapy. Methods: PubMed, Cochrane CENTRAL, EMBASE, EBSCO, Web of Science and CINAHL databases were searched from January 01, 2001 through September 30, 2013. Systemic review of randomized controlled trials (RCTs) comparing the use of NOACs (apixaban, dabigatran and rivaroxaban) with conventional therapy was performed. Clinical and outcome data were extracted from individual studies by 2 independent authors. Primary endpoint of interest was transfusion events in the NOAC and comparator arms. Random effects model was used to pool event rates and results were expressed as risk ratios (RR) with 95% confidence intervals (CIs). Results: Fifteen randomized controlled trials (RCTs) including a total of 36,176 patients were included for analysis. Transfusion events were not higher with use of NOACs in comparison to all comparators in patients undergoing hip and knee surgery- RR 1.02 (95% CI 0.98-1.06), p=0.40. Statistical heterogeneity was negligible (I2=22%). Conclusions: Blood transfusion events with NOAC use were not significantly higher than that with conventional drugs in thromboprophylaxis for hip and knee surgery patients, as noted in evidence from contemporary RCTs.

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Upfront Surgery and Surgery Following Neoadjuvant Treatment of Pancreatic Ductal Adenocarcinoma: A Comparative Analysis of Short-term Postoperative Outcomes

Anticancer Research ◽

10.21873/anticanres.15386 ◽

2021 ◽

Vol 41 (11) ◽

pp. 5703-5712

Author(s):

JI HYE JUNG ◽

SO KYUNG YOON ◽

SO JEONG YOON ◽

SANG HYUN SHIN ◽

IN WOONG HAN ◽

...

Keyword(s):

Comparative Analysis ◽

Pancreatic Ductal Adenocarcinoma ◽

Neoadjuvant Treatment ◽

Postoperative Outcomes ◽

Ductal Adenocarcinoma ◽

Short Term

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THALIDOMIDE FOR PATIENTS WITH THALASSEMIA INTERMEDIA: A RETROSPECTIVE MULTICENTER CLINICAL STUDY

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2020.021 ◽

2020 ◽

Vol 12 (1) ◽

pp. e2020021

Author(s):

Kun Yang ◽

Yi Wu ◽

Yali Zhou ◽

Tianhong Zhou ◽

Li Wang ◽

...

Keyword(s):

Blood Transfusion ◽

Laboratory Data ◽

Drug Discontinuation ◽

Therapeutic Effects ◽

Efficacy And Safety ◽

Thalassemia Intermedia ◽

Short Term ◽

Long Term Follow Up

Objective: This study focused on the efficacy and safety of thalidomide for patients with thalassemia intermedia (TI) in a multicenter trial. Methods：Clinical and laboratory data of 62 patients subjected to thalidomide therapy in four centers were retrospectively analyzed. We evaluated the efficacy and safety of thalidomide in the short-term (three months) and long-term follow-up (12 and 24 months). Response to thalidomide was defined as follows: Main Responder (MaR) showing an increase in Hb level of >2.0 g/dl or removal from blood transfusion and Minor Responder (MiR) achieving elevated hemoglobin (Hb) level of 1.0-2.0 g/dl or ≥50% reduction in blood transfusion frequency. Results：The overall response rate (ORR) of 62 patients with TI was 93.5% (58/62), with MaR and MiR rates accounting for 62.9% (39/62) and 30.6% (19/62) in short-term follow-up and 66.1% (41/62) and 27.4% (17/62) in long-term follow-up, respectively. The clinical response during long-term follow-up was maintained and the Hb level remained stable during the observation period. The response was still observed in patients with dose reduction despite a slight decrease in Hb level. However, Hb decreased rapidly to the baseline level after drug discontinuation. No effect of thalidomide on spleen size in nonsplenectomized patients was evident. Minimal side-effects were documented throughout, except peripheral neurotoxicity in one patient. Nevertheless, the mean serum ferritin (SF) level was significantly increased after treatment. Conclusion: Thalidomide had significant therapeutic effects on patients with TI, and the response was sustained with acceptable short-term and long-term adverse reactions. While these preliminary results support the potential long-term efficacy and safety of thalidomide as a therapeutic agent for TI, several issues need to be addressed before its application in the clinic.

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Abstract 597: Lung tumor histology as prognostic factor for short-term postoperative outcomes

10.1158/1538-7445.am2018-597 ◽

2018 ◽

Author(s):

Roger Gerard ◽

Frank Velez-Cubian ◽

Carla Moodie ◽

Joseph Garrett ◽

Jacques Fontaine ◽

...

Keyword(s):

Prognostic Factor ◽

Lung Tumor ◽

Postoperative Outcomes ◽

Short Term ◽

Tumor Histology

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