Short term outcomes associated with patients requiring blood transfusion following elective laminectomy and fusion for lumbar stenosis: A propensity-matched analysis

2021 ◽  
Vol 90 ◽  
pp. 184-190
Author(s):  
Spencer C. Darveau ◽  
Nathan J. Pertsch ◽  
Steven A. Toms ◽  
Robert J. Weil
Keyword(s):  
Blood Transfusion ◽  
Lumbar Stenosis ◽  
Short Term ◽  
Laminectomy And Fusion

scholarly journals Expectant Management of Miscarriage in View of NICE Guideline 154

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Junaid Rafi ◽  
Haroona Khalil
Keyword(s):  
Blood Transfusion ◽  
Success Rate ◽  
Prospective Observational Study ◽  
Expectant Management ◽  
District General Hospital ◽  
Short Term ◽  
Nice Guideline ◽  
The United Kingdom ◽  
Products Of Conception ◽  
Incomplete Miscarriage

Objective. To find out the success rate of conservative management of complete two weeks for miscarriage in view of NICE Guideline 154.Design. Prospective observational study.Setting. Early pregnancy assessment units of District General Hospital in the United Kingdom.Participants. Women of less than 14 weeks’ gestation, with a diagnosis of miscarriage (missed miscarriage/anembryonic or incomplete miscarriage).Interventions.Expectant management for two weeks.Main Outcome Measure.(1) Efficacy of 2-week expectant management, that is, complete resolution of miscarriage based either on self-reporting of patient after passing products of conception at home between D0 and D14 of expectant management or confirmation on scan at D14, and (2) short-term complications needing strong analgesia, blood transfusion, and antibiotics.Results. Expectant management of miscarriage for 2 weeks from the day of diagnosis was successful in 58% (64 /111) and failed in 42% (47/111).Conclusions. Expectant management success rate is consistent with the results from the longitudinal studies and RCTs published in the past. It is a safe option as none of the patients on expectant/medical management needed strong analgesia/antibiotics or blood transfusion.

Abstract 16074: Risk of Blood Transfusion(s) With New Oral Anticoagulants for Short-Term Thromboprophylaxis in Hip and Knee Surgery: Insights From a Meta-Analysis of Fifteen Randomized Trials Including 36,176 Patients

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Parasuram Krishnamoorthy ◽  
Saurav Chatterjee ◽  
Jalaj Garg ◽  
Partha Sardar ◽  
Franz Messerli ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Randomized Controlled Trials ◽  
Conventional Therapy ◽  
Oral Anticoagulants ◽  
Knee Surgery ◽  
New Oral Anticoagulants ◽  
Controlled Trials ◽  
Short Term ◽  
Randomized Controlled ◽  
Hip And Knee Surgery

Introduction: Blood transfusions have been associated with poor outcomes in cardiac patients. The objective of our study was to systematically examine the overall risk of blood transfusion with new oral anticoagulants (NOACs) and individually in thromboprophylaxis for hip and knee surgery. Hypothesis: Treatment with NOACs is safe for short-term thromboprophylaxis in patients undergoing hip and knee surgery compared with conventional therapy. Methods: PubMed, Cochrane CENTRAL, EMBASE, EBSCO, Web of Science and CINAHL databases were searched from January 01, 2001 through September 30, 2013. Systemic review of randomized controlled trials (RCTs) comparing the use of NOACs (apixaban, dabigatran and rivaroxaban) with conventional therapy was performed. Clinical and outcome data were extracted from individual studies by 2 independent authors. Primary endpoint of interest was transfusion events in the NOAC and comparator arms. Random effects model was used to pool event rates and results were expressed as risk ratios (RR) with 95% confidence intervals (CIs). Results: Fifteen randomized controlled trials (RCTs) including a total of 36,176 patients were included for analysis. Transfusion events were not higher with use of NOACs in comparison to all comparators in patients undergoing hip and knee surgery- RR 1.02 (95% CI 0.98-1.06), p=0.40. Statistical heterogeneity was negligible (I2=22%). Conclusions: Blood transfusion events with NOAC use were not significantly higher than that with conventional drugs in thromboprophylaxis for hip and knee surgery patients, as noted in evidence from contemporary RCTs.

scholarly journals THALIDOMIDE FOR PATIENTS WITH THALASSEMIA INTERMEDIA: A RETROSPECTIVE MULTICENTER CLINICAL STUDY

2020 ◽  
Vol 12 (1) ◽  
pp. e2020021
Author(s):  
Kun Yang ◽  
Yi Wu ◽  
Yali Zhou ◽  
Tianhong Zhou ◽  
Li Wang ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Laboratory Data ◽  
Drug Discontinuation ◽  
Therapeutic Effects ◽  
Efficacy And Safety ◽  
Thalassemia Intermedia ◽  
Short Term ◽  
Long Term Follow Up

Objective: This study focused on the efficacy and safety of thalidomide for patients with thalassemia intermedia (TI) in a multicenter trial. Methods：Clinical and laboratory data of 62 patients subjected to thalidomide therapy in four centers were retrospectively analyzed. We evaluated the efficacy and safety of thalidomide in the short-term (three months) and long-term follow-up (12 and 24 months). Response to thalidomide was defined as follows: Main Responder (MaR) showing an increase in Hb level of >2.0 g/dl or removal from blood transfusion and Minor Responder (MiR) achieving elevated hemoglobin (Hb) level of 1.0-2.0 g/dl or ≥50% reduction in blood transfusion frequency. Results：The overall response rate (ORR) of 62 patients with TI was 93.5% (58/62), with MaR and MiR rates accounting for 62.9% (39/62) and 30.6% (19/62) in short-term follow-up and 66.1% (41/62) and 27.4% (17/62) in long-term follow-up, respectively. The clinical response during long-term follow-up was maintained and the Hb level remained stable during the observation period. The response was still observed in patients with dose reduction despite a slight decrease in Hb level. However, Hb decreased rapidly to the baseline level after drug discontinuation. No effect of thalidomide on spleen size in nonsplenectomized patients was evident. Minimal side-effects were documented throughout, except peripheral neurotoxicity in one patient. Nevertheless, the mean serum ferritin (SF) level was significantly increased after treatment. Conclusion: Thalidomide had significant therapeutic effects on patients with TI, and the response was sustained with acceptable short-term and long-term adverse reactions. While these preliminary results support the potential long-term efficacy and safety of thalidomide as a therapeutic agent for TI, several issues need to be addressed before its application in the clinic.

scholarly journals MP31-06 PERIOPERATIVE BLOOD TRANSFUSION PREDICTS SHORT-TERM MORBIDITY AND MORTALITY IN RADICAL AND PARTIAL NEPHRECTOMIES: EVIDENCE FROM NSQIP

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Wilson Sui ◽  
Ifeanyi Onyeji ◽  
Justin T. Matulay ◽  
Marissa C. Velez ◽  
Maxwell B. James ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Morbidity And Mortality ◽  
Short Term ◽  
Perioperative Blood Transfusion

scholarly journals Preoperative blood transfusion is a predictor of worse short-term postoperative outcomes after colectomy

Surgery ◽  
2017 ◽  
Vol 161 (4) ◽  
pp. 1067-1075 ◽  
Author(s):  
Christina M. Papageorge ◽  
Gregory D. Kennedy ◽  
Evie H. Carchman
Keyword(s):  
Blood Transfusion ◽  
Postoperative Outcomes ◽  
Short Term

scholarly journals Osteosynthesis of non-displaced femoral neck fractures in the elderly population using the femoral neck system (FNS): short-term clinical and radiological outcomes

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Oscar Vazquez ◽  
Axel Gamulin ◽  
Didier Hannouche ◽  
Wilson Belaieff
Keyword(s):  
Blood Transfusion ◽  
Femoral Neck ◽  
Elderly Population ◽  
The Elderly ◽  
Femoral Neck Fractures ◽  
Medical Complications ◽  
Short Term ◽  
Duration Of Surgery ◽  
Discharge Location ◽  
Surgical Site Complications

Abstract Background Femoral neck fractures (FNF) are frequent in the elderly population, and surgical management is indicated in the vast majority of cases. Osteosynthesis is an alternative to arthroplasty for non-displaced FNF. Triple screw construct (TS) and the dynamic hip screw system (DHS) are considered gold standards for osteosynthesis. The newly available femoral neck system (FNS) currently lacks evidence as to whether it is a valid alternative to TS and DHS. The purpose of this study was to evaluate the short-term clinical and radiological outcomes after non-displaced (Garden I and II) FNF osteosynthesis using TS, DHS, and FNS. Methods All the patients of the author’s institution aged ≥ 75 years with a non-displaced (Garden I and II) FNF eligible for osteosynthesis between November 2015 and December 2019 were included in this single-center retrospective non-randomized study. Patients were treated with either TS, DHS, or FNS depending on the surgeon’s preference. Clinical data (age, gender, ASA score, duration of surgery, need for blood transfusion and number of packed red blood cells transfused, surgical site complications, length of stay, discharge location, postoperative medical complications and readmission within 30 days, and mortality within 3 months) were extracted from the patients’ charts. The radiological analysis assessed the fracture classification, fracture impaction, and proximal femur shortening at 3 and 6 months using the institutional imaging software. Results Baseline characteristics in the TS (n = 32), DHS (n = 16), and FNS (n = 15) groups were similar with respect to age (mean 85 years), gender (female to male ratio 4:1), and ASA score. There were no significant differences across the groups for the need for blood transfusion, surgical site complications, length of stay, postoperative medical complications and readmission within 30 days, discharge location, and mortality within 3 months. The duration of surgery was significantly lower in the FNS group (43.3 vs 68.8 min; p < 0.001). The radiological assessment found similar impaction (5.2 mm ± 4.8) and shortening (8.6 mm ± 8.2) in all groups that did not seem to progress after 3 months. Conclusion The FNS appears to be a valid alternative implant for FNF osteosynthesis and is associated with a shorter operative time than TS and DHS. Short-term clinical and radiological outcomes of FNS are similar to TS and DHS implants. Further long-term multicenter randomized studies are however necessary to confirm these first results.

scholarly journals Osteosynthesis of Non-displaced Femoral Neck Fractures in the Elderly Population Using the Femoral Neck System (FNS): Short-term Clinical and Radiological Outcomes

2021 ◽  
Author(s):  
Oscar Vazquez ◽  
Axel Gamulin ◽  
Didier Hannouche ◽  
Wilson Belaieff
Keyword(s):  
Blood Transfusion ◽  
Femoral Neck ◽  
Elderly Population ◽  
The Elderly ◽  
Femoral Neck Fractures ◽  
Medical Complications ◽  
Short Term ◽  
Duration Of Surgery ◽  
Discharge Location ◽  
Surgical Site Complications

Abstract Background: femoral neck fractures (FNF) are frequent in the elderly population and surgical management is indicated in the vast majority of cases. Osteosynthesis is an alternative to arthroplasty for non-displaced FNF. Triple screw construct (TS) and the Dynamic Hip Screw system (DHS) are considered gold standards for osteosynthesis. The newly available Femoral Neck System (FNS) currently lacks evidence as to whether it is a valid alternative to TS and DHS. The purpose of this study was to evaluate short term clinical and radiological outcomes after non-displaced (Garden I and II) FNF osteosynthesis using TS, DHS and FNS. Methods: all the patients of the author’s institution aged ≥ 75y with a non-displaced (Garden I and II) FNF eligible to osteosynthesis between November 2015 and December 2019 were included in this single-center retrospective non-randomized study. Patients were treated with either TS, DHS or FNS depending on surgeon’s preference. Clinical data (age, gender, duration of surgery, need for blood transfusion and number of packed red blood cells transfused, surgical site complications, length of stay, discharge location, postoperative medical complications and readmission within 30 days, and mortality within 3 months) were extracted from patients’ charts. Radiological analysis assessed fracture classification, fracture impaction and proximal femur shortening at 3 and 6 months using the institutional imaging software.Results: the TS (n=32), DHS (n=16) and FNS (n=15) groups were similar with respect to age (mean 85y) and gender (female: male ratio 4:1). There were no significant differences across groups for need for blood transfusion, surgical site complications, length of stay, postoperative medical complications and readmission within 30 days, discharge location and mortality within 3 months. Duration of surgery was significantly lower in the FNS group (43.3 vs 68.8min; p<0.001). Radiological assessment found similar impaction (5,2mm ± 4.8) and shortening (8.6mm ± 8.2) in all groups that did not seem to progress after 3 months. Conclusion: The FNS appears to be a valid alternative implant for FNF osteosynthesis and is associated with shorter operative time than TS and DHS. Short-term clinical and radiological outcomes of FNS are similar to TS and DHS implants. Further long-term multi-center randomized studies are however necessary to confirm these first results.

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