Impact of measurement of skeletal muscle mass on clinical outcomes in patients with esophageal cancer undergoing esophagectomy after neoadjuvant chemotherapy

Surgery ◽  
2019 ◽  
Vol 166 (6) ◽  
pp. 1041-1047 ◽  
Author(s):  
Tomo Ishida ◽  
Tomoki Makino ◽  
Makoto Yamasaki ◽  
Koji Tanaka ◽  
Yasuhiro Miyazaki ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Esophageal Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Clinical Outcomes ◽  
Muscle Mass ◽  
Skeletal Muscle Mass

scholarly journals O16-2 Prognostic impacts of change in skeletal muscle mass during neoadjuvant chemotherapy in patients with esophageal cancer

2021 ◽  
Vol 32 ◽  
pp. S292
Author(s):  
Tsuyoshi Harada ◽  
Noriatsu Tatematsu ◽  
Junnya Ueno ◽  
You Koishihara ◽  
Nobuko Konishi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Esophageal Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Muscle Mass ◽  
Skeletal Muscle Mass

630 IMPACT OF LOW SKELETAL MUSCLE MASS AND DENSITY ON OUTCOMES OF LOCALLY ADVANCED ESOPHAGEAL CANCER PATIENTS TREATED WITH RADICAL RADIOTHERAPY

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Yuan Wang ◽  
Ningjing Yang ◽  
Hongyuan Jia ◽  
Long Liang ◽  
Lei Wu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Esophageal Cancer ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Mass Density ◽  
Locally Advanced ◽  
Radical Radiotherapy ◽  
Term Survival ◽  
Locally Advanced Esophageal Cancer

Abstract   Low skeletal muscle mass and density are independent predictors of clinical outcomes in multiple gastrointestinal cancers. However, its effect on the long-term survival of locally advanced esophageal cancer patients undergoing radical radiotherapy is still unclear. Methods Patients with stage II-III esophageal cancer undergoing radical radiotherapy, enrolled in a observational cohort study, were included. Skeletal muscle mass and density were measured on CT. Patients with high and low skeletal muscle mass and density were compared regarding overall survival (OS). Results 165 patients (75.8% males, median age 63) were included, from March-2012 to September-2017. Before radiotherapy, 26.7% patients had low skeletal-muscle-mass and 23.0% patients had low skeletal-muscle-density. After radiotherapy, 40.6% patients had low skeletal-muscle-mass and 30.3% patients had low skeletal-muscle-density.The median OS of high skeletal-muscle-mass/density group was significantly higher than that of low skeletal-muscle-mass/density group before radiotherapy (28.7 vs 28.2 months, p = 0.041; 29.6 vs 16.9 months, p = 0.025). The median OS of high skeletal-muscle-mass/density group was also significantly higher than that of low skeletal-muscle-mass/density group after radiotherapy (30.3 vs 20.3 months, P = 0.012; 29.6 vs 17.2 months, p = 0.018). Conclusion Low skeletal muscle mass and density are associated with long-term outcome in patients undergoing radical radiotherapy. It is suggested that oncologists should pay more attention to the management of muscle mass and density of patients with esophageal cancer undergoing radiotherapy in order to improve their nutritional status and long-term survival.

scholarly journals Predictors of changes in skeletal muscle mass after esophagectomy in elderly patients with esophageal cancer

2021 ◽  
Author(s):  
Tsuyoshi Harada ◽  
Noriatsu Tatematsu ◽  
Junya Ueno ◽  
Yu Koishihara ◽  
Nobuko Konishi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Esophageal Cancer ◽  
Elderly Patients ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Quadriceps Muscle ◽  
Computed Tomography Images ◽  
Ratio Change ◽  
Comprehensive Rehabilitation ◽  
The Mean

Abstract Purpose : Although a change in skeletal muscle mass index (SMI) 4 months after esophagectomy impacts prognosis, predictors of a change in SMI have not been revealed. The purpose of this exploratory retrospective study was to clarify the predictors of a change in SMI after curative esophagectomy in elderly patients with esophageal cancer.Methods : Fifty-four patients who underwent esophagectomy and perioperative rehabilitation from 2015 to 2018 were enrolled. Preoperative and postoperative SMI (cm 2 /m 2 ) were calculated using computed tomography images. The ratio change in SMI was calculated as follows: (postoperative SMI − preoperative SMI) ÷ preoperative SMI × 100%. Potential predictors of a change in SMI ratio were analyzed by multiple regression. Results : The mean ratio change in SMI 4 months after esophagectomy was −7.1% ± 9.4%. The ratio change in quadriceps muscle strength in the first month after surgery ([postoperative strength − preoperative strength] ÷ preoperative strength × 100%) (standardized β = .273, p = .038) and neoadjuvant chemotherapy (NAC) (standardized β = .398, p = .006) were predictors of the ratio change in SMI independent of age, sex, pathological stage, and preoperative SMI. Conclusion : Quadriceps muscle weakness in the first month after esophagectomy and NAC were predictors of the ratio change in SMI after esophagectomy. Continuous postoperative comprehensive rehabilitation and supportive care may inhibit loss of skeletal muscle mass.

scholarly journals Loss of Skeletal Muscle Mass During Neoadjuvant Chemoradiotherapy Predicts Postoperative Mortality in Esophageal Cancer Surgery

2015 ◽  
Vol 22 (13) ◽  
pp. 4445-4452 ◽  
Author(s):  
Kostan W. Reisinger ◽  
Joanna W. A. M. Bosmans ◽  
Martine Uittenbogaart ◽  
Abdulaziz Alsoumali ◽  
Martijn Poeze ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Esophageal Cancer ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Neoadjuvant Chemoradiotherapy ◽  
Postoperative Mortality ◽  
Cancer Surgery ◽  
Esophageal Cancer Surgery

scholarly journals Low skeletal muscle mass in stented esophageal cancer predicts poor survival: A retrospective observational study

2018 ◽  
Vol 9 (11) ◽  
pp. 1429-1436 ◽  
Author(s):  
Tommi Järvinen ◽  
Ilkka Ilonen ◽  
Juha Kauppi ◽  
Kirsi Volmonen ◽  
Jarmo Salo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Esophageal Cancer ◽  
Observational Study ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Retrospective Observational Study ◽  
Poor Survival

scholarly journals Decreased Skeletal Muscle Mass After Neoadjuvant Therapy Correlates with Poor Prognosis in Patients with Esophageal Cancer

2016 ◽  
Vol 36 (12) ◽  
pp. 6677-6686 ◽  
Author(s):  
JIAJIA LIU ◽  
SATORU MOTOYAMA ◽  
YUSUKE SATO ◽  
AKIYUKI WAKITA ◽  
YUTA KAWAKITA ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Esophageal Cancer ◽  
Neoadjuvant Therapy ◽  
Muscle Mass ◽  
Poor Prognosis ◽  
Skeletal Muscle Mass
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