scholarly journals Impact on postoperative complications of changes in skeletal muscle mass during neoadjuvant chemotherapy for gastro‐oesophageal cancer

BJS Open ◽  
2020 ◽  
Vol 4 (5) ◽  
pp. 847-854
Author(s):  
R. B. Boer ◽  
K. I. Jones ◽  
S. Ash ◽  
G. I. Boxel ◽  
R. S. Gillies ◽  
...  
2019 ◽  
Vol 44 (4) ◽  
pp. 714-721 ◽  
Author(s):  
Christian Galata ◽  
Janina Hodapp ◽  
Christel Weiß ◽  
Ioannis Karampinis ◽  
Georgi Vassilev ◽  
...  

Oncology ◽  
2019 ◽  
Vol 98 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Norihiro Matsuura ◽  
Masaaki Motoori ◽  
Kazumasa Fujitani ◽  
Yujiro Nishizawa ◽  
Hisateru Komatsu ◽  
...  

2021 ◽  
Author(s):  
Zhen Fang ◽  
Peijuan Li ◽  
Jin Liu ◽  
Wei Chong ◽  
Fengying Du ◽  
...  

Abstract Background: Increasing evidence has indicated that low skeletal muscle mass is linked with cancer prognosis, but existing have shown contrasting results. The purpose of the study is to determine the impact of preoperative low skeletal muscle mass (LSMM) on complications and survival of patients who undergo laparoscopic gastrectomy for gastric cancer (GC).Methods: Patients who undergo laparoscopic gastrectomy for GC were enrolled and third lumbar vertebra psoas muscles index (PMI) was assessed by computer tomography (CT). Using propensity score matching (1:1) to obtain 2 well-balanced cohorts for available variables influencing clinical outcomes, comparing the postoperative complications and 3-year overall survival (OS) between LSMM group and non-LSMM group.Results: A total of 386 patients, 226 were matched for analyses. Compared with the non-LSMM group, the LSMM group manifested significantly shorter 3-year OS (58.14% vs 71.95%, P=0.034). However, the incidence of postoperative complications was no difference between two groups after matching. After stratification based on the pT stage of the tumor, statistically significant difference in the 3-year OS rates of the advance GC cohort between the two groups were observed.Conclusions: LSMM predicts a poor prognosis for patients with advance GC and it is not associated with postoperative complications.


Surgery ◽  
2019 ◽  
Vol 166 (6) ◽  
pp. 1041-1047 ◽  
Author(s):  
Tomo Ishida ◽  
Tomoki Makino ◽  
Makoto Yamasaki ◽  
Koji Tanaka ◽  
Yasuhiro Miyazaki ◽  
...  

2021 ◽  
Vol 32 ◽  
pp. S292
Author(s):  
Tsuyoshi Harada ◽  
Noriatsu Tatematsu ◽  
Junnya Ueno ◽  
You Koishihara ◽  
Nobuko Konishi ◽  
...  

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kei Yokozuka ◽  
Koichi Tomita ◽  
Masashi Nakagawa ◽  
Itsuki Koganezawa ◽  
Shigeto Ochiai ◽  
...  

Abstract Background Gastrointestinal surgery in elderly individuals presents unexpected postoperative complications. However, predicting postoperative complications in elderly patients undergoing gastrointestinal surgeries is challenging because of the lack of a reliable preoperative evaluation system. We aimed to prospectively evaluate three new preoperative assessment methods to predict the postoperative complications in elderly patients undergoing elective gastrointestinal surgery. Moreover, we aimed to identify new risk factors of postoperative complications in this patient group. Methods This prospective cohort study enrolled 189 patients (age ≥ 65 years) who underwent elective gastrointestinal surgery at Tokyo Medical University Hachioji Medical Center between April 2017 and March 2019. Assessments performed preoperatively included the biological impedance analysis for evaluating the skeletal muscle mass, the SF-8 questionnaire for evaluating the subjective health-related quality of life, and the blood pressure/pulse wave test for assessing arteriosclerosis. The risk factors for Clavien–Dindo Grade ≥ III postoperative complications were assessed using these new evaluation methods. Results Clavien–Dindo Grade ≥ III postoperative complications were observed in 28 patients (14.8%). Univariate and multivariate analyses identified male sex, low skeletal muscle mass, and cardio-ankle vascular index ≥ 10 (arteriosclerosis) as significant independent risk factors of developing Grade ≥ III complications. Conclusions Male sex, low skeletal muscle mass, and arteriosclerosis were significant risk factors of postoperative complications in elderly patients undergoing elective gastrointestinal surgery. The obtained knowledge could be useful in identifying high-risk patients who require careful perioperative management.


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