Predictors of changes in skeletal muscle mass after esophagectomy in elderly patients with esophageal cancer

Abstract Purpose : Although a change in skeletal muscle mass index (SMI) 4 months after esophagectomy impacts prognosis, predictors of a change in SMI have not been revealed. The purpose of this exploratory retrospective study was to clarify the predictors of a change in SMI after curative esophagectomy in elderly patients with esophageal cancer.Methods : Fifty-four patients who underwent esophagectomy and perioperative rehabilitation from 2015 to 2018 were enrolled. Preoperative and postoperative SMI (cm 2 /m 2 ) were calculated using computed tomography images. The ratio change in SMI was calculated as follows: (postoperative SMI − preoperative SMI) ÷ preoperative SMI × 100%. Potential predictors of a change in SMI ratio were analyzed by multiple regression. Results : The mean ratio change in SMI 4 months after esophagectomy was −7.1% ± 9.4%. The ratio change in quadriceps muscle strength in the first month after surgery ([postoperative strength − preoperative strength] ÷ preoperative strength × 100%) (standardized β = .273, p = .038) and neoadjuvant chemotherapy (NAC) (standardized β = .398, p = .006) were predictors of the ratio change in SMI independent of age, sex, pathological stage, and preoperative SMI. Conclusion : Quadriceps muscle weakness in the first month after esophagectomy and NAC were predictors of the ratio change in SMI after esophagectomy. Continuous postoperative comprehensive rehabilitation and supportive care may inhibit loss of skeletal muscle mass.

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771-P: Protein Intake at Breakfast Contributes to Maintenance of Skeletal Muscle Mass in Japanese Elderly Patients with Type 2 Diabetes

Diabetes ◽

10.2337/db19-771-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 771-P

Author(s):

SODAI KUBOTA ◽

HITOSHI KUWATA ◽

SAKI OKAMOTO ◽

DAISUKE YABE ◽

KENTA MUROTANI ◽

...

Keyword(s):

Type 2 Diabetes ◽

Skeletal Muscle ◽

Elderly Patients ◽

Muscle Mass ◽

Protein Intake ◽

Skeletal Muscle Mass ◽

P Protein ◽

Japanese Elderly

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630 IMPACT OF LOW SKELETAL MUSCLE MASS AND DENSITY ON OUTCOMES OF LOCALLY ADVANCED ESOPHAGEAL CANCER PATIENTS TREATED WITH RADICAL RADIOTHERAPY

Diseases of the Esophagus ◽

10.1093/dote/doab052.630 ◽

2021 ◽

Vol 34 (Supplement_1) ◽

Author(s):

Yuan Wang ◽

Ningjing Yang ◽

Hongyuan Jia ◽

Long Liang ◽

Lei Wu ◽

...

Keyword(s):

Skeletal Muscle ◽

Esophageal Cancer ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Mass Density ◽

Locally Advanced ◽

Radical Radiotherapy ◽

Term Survival ◽

Locally Advanced Esophageal Cancer

Abstract Low skeletal muscle mass and density are independent predictors of clinical outcomes in multiple gastrointestinal cancers. However, its effect on the long-term survival of locally advanced esophageal cancer patients undergoing radical radiotherapy is still unclear. Methods Patients with stage II-III esophageal cancer undergoing radical radiotherapy, enrolled in a observational cohort study, were included. Skeletal muscle mass and density were measured on CT. Patients with high and low skeletal muscle mass and density were compared regarding overall survival (OS). Results 165 patients (75.8% males, median age 63) were included, from March-2012 to September-2017. Before radiotherapy, 26.7% patients had low skeletal-muscle-mass and 23.0% patients had low skeletal-muscle-density. After radiotherapy, 40.6% patients had low skeletal-muscle-mass and 30.3% patients had low skeletal-muscle-density.The median OS of high skeletal-muscle-mass/density group was significantly higher than that of low skeletal-muscle-mass/density group before radiotherapy (28.7 vs 28.2 months, p = 0.041; 29.6 vs 16.9 months, p = 0.025). The median OS of high skeletal-muscle-mass/density group was also significantly higher than that of low skeletal-muscle-mass/density group after radiotherapy (30.3 vs 20.3 months, P = 0.012; 29.6 vs 17.2 months, p = 0.018). Conclusion Low skeletal muscle mass and density are associated with long-term outcome in patients undergoing radical radiotherapy. It is suggested that oncologists should pay more attention to the management of muscle mass and density of patients with esophageal cancer undergoing radiotherapy in order to improve their nutritional status and long-term survival.

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Loss of Skeletal Muscle Mass During Neoadjuvant Chemoradiotherapy Predicts Postoperative Mortality in Esophageal Cancer Surgery

Annals of Surgical Oncology ◽

10.1245/s10434-015-4558-4 ◽

2015 ◽

Vol 22 (13) ◽

pp. 4445-4452 ◽

Cited By ~ 64

Author(s):

Kostan W. Reisinger ◽

Joanna W. A. M. Bosmans ◽

Martine Uittenbogaart ◽

Abdulaziz Alsoumali ◽

Martijn Poeze ◽

...

Keyword(s):

Skeletal Muscle ◽

Esophageal Cancer ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Neoadjuvant Chemoradiotherapy ◽

Postoperative Mortality ◽

Cancer Surgery ◽

Esophageal Cancer Surgery

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Low skeletal muscle mass in stented esophageal cancer predicts poor survival: A retrospective observational study

Thoracic Cancer ◽

10.1111/1759-7714.12855 ◽

2018 ◽

Vol 9 (11) ◽

pp. 1429-1436 ◽

Cited By ~ 1

Author(s):

Tommi Järvinen ◽

Ilkka Ilonen ◽

Juha Kauppi ◽

Kirsi Volmonen ◽

Jarmo Salo ◽

...

Keyword(s):

Skeletal Muscle ◽

Esophageal Cancer ◽

Observational Study ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Retrospective Observational Study ◽

Poor Survival

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ASSOCIATION BETWEEN GAIT SPEED MEASURED USING A WEARABLE DEVICE AND SARCOPENIA

Innovation in Aging ◽

10.1093/geroni/igz038.3242 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S885-S886

Author(s):

Min-gu Kang ◽

Kwang-il Kim ◽

Joon Koo Kang ◽

Seong-Ji Kang ◽

Hye-Kang Roh ◽

...

Keyword(s):

Skeletal Muscle ◽

Muscle Mass ◽

Gait Speed ◽

Skeletal Muscle Mass ◽

Daily Life ◽

Measurement Data ◽

Lower Limbs ◽

University Hospital ◽

Speed Measurement ◽

The Mean

Abstract As slow gait speed is a major feature of frailty and a diagnostic criterion of sarcopenia, gait speed measurement is widely used. Nowadays, with development of wearable devices, it is possible to measure daily-life gait speed without additional effort just by wearing the device. It is meaningful to measure daily-life gait speed and to analyze the association between the speed and sarcopenia. Participants were men over 50 years of age who visited the university hospital. Daily-life gait speed was checked using a smart belt (WELT) for 4 weeks. Afterwards, a survey about past medical history, usual gait speed measurement, handgrip strength measurement, and dual energy X-ray absorptiometry were performed. A total of 217,548 daily-life gait speed measurement data were analyzed for 106 participants. The mean daily-life gait speed was 1.23 ± 0.26 m/s. The mean age was 71.1 ± 7.6, and daily-life gait speed was significantly slower as people get older. (P<0.001) Additionally, weekday gait speed (1.23 ± 0.26 m/s) was significantly faster than weekend gait speed (1.22 ± 0.26 m/s). (P<0.001) Participants with sarcopenia (1.15 ± 0.25 m/s) had significantly slower mean daily-life gait speed than normal subjects (1.23 ± 0.26 m/s). (P<0.001) In analyzing factors related to gait speed, age and skeletal muscle mass of lower limbs were significantly associated with mean daily-life gait speed. Additional information about the gait speed can be obtained by measuring daily-life gait speed, and the daily-life gait speed has a significant association with the skeletal muscle mass of lower limbs.

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Decreased Skeletal Muscle Mass After Neoadjuvant Therapy Correlates with Poor Prognosis in Patients with Esophageal Cancer

Anticancer Research ◽

10.21873/anticanres.11278 ◽

2016 ◽

Vol 36 (12) ◽

pp. 6677-6686 ◽

Cited By ~ 17

Author(s):

JIAJIA LIU ◽

SATORU MOTOYAMA ◽

YUSUKE SATO ◽

AKIYUKI WAKITA ◽

YUTA KAWAKITA ◽

...

Keyword(s):

Skeletal Muscle ◽

Esophageal Cancer ◽

Neoadjuvant Therapy ◽

Muscle Mass ◽

Poor Prognosis ◽

Skeletal Muscle Mass

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Low muscle mass assessed by psoas muscle area is associated with clinical adverse events in elderly patients with heart failure

PLoS ONE ◽

10.1371/journal.pone.0247140 ◽

2021 ◽

Vol 16 (2) ◽

pp. e0247140

Author(s):

Takehiro Funamizu ◽

Yuji Nagatomo ◽

Mike Saji ◽

Nobuo Iguchi ◽

Hiroyuki Daida ◽

...

Keyword(s):

Heart Failure ◽

Skeletal Muscle ◽

Adverse Events ◽

Elderly Patients ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Psoas Muscle ◽

Composite Endpoint ◽

Left Ventricular Ejection ◽

Muscle Area

Background Acute decompensated heart failure (ADHF) is a growing healthcare burden with increasing prevalence and comorbidities due to progressive aging society. Accumulating evidence suggest that low skeletal muscle mass has a negative impact on clinical outcome in elderly adult population. We sought to determine the significance of psoas muscle area as a novel index of low skeletal muscle mass in elderly patients with ADHF. Methods In this single-center retrospective observational study, we reviewed consecutive 865 elderly participants (65 years or older) who were hospitalized for ADHF and 392 were available for analysis (79 years [74–85], 56% male). Cross-sectional areas of psoas muscle at the level of fourth lumbar vertebra were measured by computed tomography and normalized by the square of height to calculate psoas muscle index (PMI, cm2/m2). Results Dividing the patients by the gender-specific quartile value (2.47 cm2/m2 for male and 1.68 cm2/m2 for female), we defined low PMI as the lowest gender-based quartile of PMI. Multiple linear regression analysis revealed female sex, body mass index (BMI), and E/e’, but not left ventricular ejection fraction, were independently associated with PMI. Kaplan-Meier analysis showed low PMI was associated with higher rate of composite endpoint of all-cause death and ADHF re-hospitalization (P = 0.033). Cox proportional hazard model analysis identified low PMI, but not BMI, was an independent predictor of the composite endpoint (Hazard ratio: 1.52 [1.06–2.16], P = 0.024). Conclusions PMI predicted future clinical adverse events in elderly patients with ADHF. Further studies are needed to assess whether low skeletal muscle mass can be a potential therapeutic target to improve the outcome of ADHF.

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