Recreational Use of Oral PDE5 Inhibitors: The Other Side of Midnight

2021 ◽  
Author(s):  
Taymour Mostafa ◽  
Moheiddin F. Alghobary
Keyword(s):  
The Other ◽  
Pde5 Inhibitors ◽  
Recreational Use

Methylenedioxymethamphetamine (MDMA): a.k.a. Ecstasy

2020 ◽  
Author(s):  
Jerrold Winter
Keyword(s):  
Therapeutic Potential ◽  
Illegal Drug ◽  
The Other ◽  
Designer Drugs ◽  
Pharmacological Effects ◽  
Other Hand ◽  
Gamma Hydroxybutyrate ◽  
Amphetamine Derivatives ◽  
Recreational Use ◽  
Vanderbilt University

As these words are written, the chemical we will call MDMA is a Schedule I drug. This means that MDMA (a) has no currently accepted medical use, (b) no currently accepted safety even under medical supervision, and (c) has a high potential for abuse. On the other hand, there are those who see great therapeutic potential in MDMA, and the Food and Drug Administration (FDA) has designated MDMA- assisted psychotherapy as a breakthrough therapy. We can foresee the day when it will be available by prescription. There is no doubt as to the chemical identity of MDMA, and much is known of its pharmacological effects in humans and in animals. The recreational drug commonly known as Ecstasy is more complicated. As is true for any illegal drug used by millions of people, demand for the drug has been met by persons not noted for their high ethical or manufacturing standards. Simply stated, short of chemical analysis, one can never be sure what street-bought Ecstasy is. For example, investigators at Vanderbilt University determined the contents of 1,214 tablets sold as Ecstasy. Only 39% contained only MDMA, while fully 46% were “substances other than MDMA.” Mixtures of MDMA and other drugs comprised the remaining 15%. On the other hand, sometimes in some places over the past several decades, nearly pure MDMA has been available on the illicit market. Nonetheless, a buyer of Ecstasy may ingest, rather than MDMA, drugs such as ketamine, gamma-hydroxybutyrate (GHB), cathinone, ephedrine, caffeine, or any one of the so-called designer drugs, many of which are amphetamine derivatives. A consequence of this pharmacological chaos is that many of the hazards associated with the use of Ecstasy have been uncritically attributed to MDMA. This fact has been a boon for those who would continue the Schedule I status of MDMA and a bane for those who would explore its therapeutic potential. However, in contrast with recreational use where purity of the drug is uncertain, MDMA in clinical trials is FDA approved and of known composition.

Recreational Use of PDE5 Inhibitors by Young Healthy Men: Recognizing This Issue Among Medical Students

2008 ◽  
Vol 5 (10) ◽  
pp. 2414-2418 ◽  
Author(s):  
Fernando Korkes ◽  
André Costa‐Matos ◽  
Renato Gasperini ◽  
Pedro V. Reginato ◽  
Marjo D.C. Perez
Keyword(s):  
Medical Students ◽  
Pde5 Inhibitors ◽  
Healthy Men ◽  
Recreational Use

scholarly journals Forest Tourism and Recreation Management in the Polish Bieszczady Mountains in the Opinion of Tourist Guides

2020 ◽  
Vol 12 (19) ◽  
pp. 7967
Author(s):  
Emilia Janeczko ◽  
Joanna Pniewska ◽  
Ernest Bielinis
Keyword(s):  
Forest Management ◽  
Protected Areas ◽  
Online Survey ◽  
The Other ◽  
Recreation Management ◽  
Nature Protection ◽  
Protection Area ◽  
Further Development ◽  
Recreational Use ◽  
Tourist Guides

This article presents results of research carried out in 2018 that aimed to determine the opinions of Bieszczady mountain guides on the scope of development of tourism and recreational infrastructure in the Bieszczady forests, Poland. The online survey included questions regarding nature protection in the Bieszczady region, factors limiting opportunities for tourism and recreation development in the Bieszczady forests, and the needs regarding new elements of tourism and recreation management of the area. Our research results indicate that the greatest impediments to the recreational use of the forest result from temporary restrictions on forest access, which are related to hunting or forest-management works. Most the interviewed guides were against further development of the tourist and recreational infrastructure in the Bieszczady forests. They were also in favor of extending the nature protection area in Bieszczady. Statistical analyses using the Kruskal–Wallis test showed that persons who are against, in favor of and neutral on extending the nature protection area in the Bieszczady forests varied significantly in their views on issues such as hunting or restrictions on forest access related to forest-management works. Compared to the other respondents, the supporters of extending the range of protected areas were more frequently against designating new recreation spaces or bonfire places in the Bieszczady forests.

Periphyton in Lakes of Different Trophy

1987 ◽  
Vol 44 (2) ◽  
pp. 296-303 ◽  
Author(s):  
Antonella Cattaneo
Keyword(s):  
Cell Volume ◽  
Organic Material ◽  
Phytoplankton Biomass ◽  
Life Form ◽  
The Other ◽  
Filamentous Algae ◽  
Periphyton Biomass ◽  
The Relationship ◽  
Recreational Use ◽  
Total P

In a study of 10 lakes in the Eastern Townships (Quebec) periphyton biomass correlated less well with total P (TP) concentration in the water than did phytoplankton biomass. The relationship with TP was improved somewhat when periphyton biomass was estimated as cell volume rather than as chlorophyll or organic material. When the community was divided among various groups according to taxa, life form, and size, only the biomasses of greens, filamentous algae, and algae exceeding 10 000 μm3 were correlated with TP. The biomass of the smaller algae, which are more readily grazed by benthos, was about the same in all lakes whereas nuisance forms increased significantly with P enrichment. At more eutrophic sites, maximal periphyton biomasses were observed in midsummer, coinciding with peak recreational use of lakes, whereas at the other sites, maxima appeared earlier in the season.

Effects of the recreational use of PDE5 inhibitors on the corpus cavernosum of young, healthy rats

2014 ◽  
Vol 46 (10) ◽  
pp. 1889-1893 ◽  
Author(s):  
Abdulmuttalip Simsek ◽  
Volkan Tugcu ◽  
Pelin Erturkuner ◽  
Faruk Alkan ◽  
Emin Ozbek ◽  
...  
Keyword(s):  
Corpus Cavernosum ◽  
Pde5 Inhibitors ◽  
Recreational Use

Stromatoporoids from the Famennian (Devonian) Wabamun Formation, Normandville oilfield, north–central Alberta, Canada

1988 ◽  
Vol 62 (03) ◽  
pp. 411-419 ◽  
Author(s):  
Colin W. Stearn
Keyword(s):  
Patch Reef ◽  
Abundant Species ◽  
The Other ◽  
North Central ◽  
Biotic Crisis

Stromatoporoids are the principal framebuilding organisms in the patch reef that is part of the reservoir of the Normandville field. The reef is 10 m thick and 1.5 km2in area and demonstrates that stromatoporoids retained their ability to build reefal edifices into Famennian time despite the biotic crisis at the close of Frasnian time. The fauna is dominated by labechiids but includes three non-labechiid species. The most abundant species isStylostroma sinense(Dong) butLabechia palliseriStearn is also common. Both these species are highly variable and are described in terms of multiple phases that occur in a single skeleton. The other species described areClathrostromacf.C. jukkenseYavorsky,Gerronostromasp. (a columnar species), andStromatoporasp. The fauna belongs in Famennian/Strunian assemblage 2 as defined by Stearn et al. (1988).

D. The Line Spectrum of Pulsating Variable Stars

1967 ◽  
Vol 28 ◽  
pp. 207-244
Author(s):  
R. P. Kraft
Keyword(s):  
Variable Stars ◽  
The Other ◽  
Line Spectrum ◽  
Afternoon Session ◽  
Empirical Information ◽  
Pulsating Variable Stars ◽  
Almost Continuous ◽  
Informal Approach

(Ed. note:Encouraged by the success of the more informal approach in Christy's presentation, we tried an even more extreme experiment in this session, I-D. In essence, Kraft held the floor continuously all morning, and for the hour and a half afternoon session, serving as a combined Summary-Introductory speaker and a marathon-moderator of a running discussion on the line spectrum of cepheids. There was almost continuous interruption of his presentation; and most points raised from the floor were followed through in detail, no matter how digressive to the main presentation. This approach turned out to be much too extreme. It is wearing on the speaker, and the other members of the symposium feel more like an audience and less like participants in a dissective discussion. Because Kraft presented a compendious collection of empirical information, and, based on it, an exceedingly novel series of suggestions on the cepheid problem, these defects were probably aggravated by the first and alleviated by the second. I am much indebted to Kraft for working with me on a preliminary editing, to try to delete the side-excursions and to retain coherence about the main points. As usual, however, all responsibility for defects in final editing is wholly my own.)

C. The Continuous Spectrum of Pulsating Variable Stars

1967 ◽  
Vol 28 ◽  
pp. 177-206
Author(s):  
J. B. Oke ◽  
C. A. Whitney
Keyword(s):  
Continuous Spectrum ◽  
Variable Stars ◽  
Velocity Fields ◽  
The Other ◽  
Line Spectrum ◽  
Direct Information ◽  
Thermodynamic Structure ◽  
Diagnostic Interpretation ◽  
Pulsating Variable Stars ◽  
The Continuum

Pecker:The topic to be considered today is the continuous spectrum of certain stars, whose variability we attribute to a pulsation of some part of their structure. Obviously, this continuous spectrum provides a test of the pulsation theory to the extent that the continuum is completely and accurately observed and that we can analyse it to infer the structure of the star producing it. The continuum is one of the two possible spectral observations; the other is the line spectrum. It is obvious that from studies of the continuum alone, we obtain no direct information on the velocity fields in the star. We obtain information only on the thermodynamic structure of the photospheric layers of these stars–the photospheric layers being defined as those from which the observed continuum directly arises. So the problems arising in a study of the continuum are of two general kinds: completeness of observation, and adequacy of diagnostic interpretation. I will make a few comments on these, then turn the meeting over to Oke and Whitney.

Observing programme for the 24-inch/36-inch Schmidt telescope

1966 ◽  
Vol 24 ◽  
pp. 337
Author(s):  
W. Iwanowska
Keyword(s):  
The Other ◽  
Schmidt Telescope ◽  
Flint Glass

A new 24-inch/36-inch//3 Schmidt telescope, made by C. Zeiss, Jena, has been installed since 30 August 1962, at the N. Copernicus University Observatory in Toruń. It is equipped with two objective prisms, used separately, one of crown the other of flint glass, each of 5° refracting angle, giving dispersions of 560Å/mm and 250Å/ mm respectively.

A hard choice for Tomasello

2020 ◽  
Vol 43 ◽  
Author(s):  
Philip Pettit
Keyword(s):  
Joint Action ◽  
The Other ◽  
Hard Choice ◽  
Margaret Gilbert ◽  
Michael Bratman ◽  
Human Sense ◽  
Sense Of Obligation

Abstract Michael Tomasello explains the human sense of obligation by the role it plays in negotiating practices of acting jointly and the commitments they underwrite. He draws in his work on two models of joint action, one from Michael Bratman, the other from Margaret Gilbert. But Bratman's makes the explanation too difficult to succeed, and Gilbert's makes it too easy.

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