T4-mediated rescue of aortic malformations in hypothyroid rats indicates maternal thyroid status can affect great vessel development

2021 ◽  
Vol 411 ◽  
pp. 115367
Author(s):  
Karen Augustine-Rauch ◽  
Jiin-Jia Liaw ◽  
Michael Graziano
Keyword(s):  
Great Vessel ◽  
Thyroid Status ◽  
Vessel Development ◽  
Maternal Thyroid

Impact of maternal thyroid disease on neonatal thyroid status

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Lakshmi Venugopalan ◽  
Aishwarya Rajan ◽  
Hemchand. K. Prasad ◽  
Anupama Sankaran ◽  
Gnanabalan Murugesan ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Thyroid Stimulating Hormone ◽  
Study Group ◽  
Thyroid Status ◽  
Case Identification ◽  
Group I ◽  
Group Ii ◽  
Maternal Thyroid ◽  
Heel Prick ◽  
Stimulating Hormone

AbstractObjectivesPrevalence of Maternal and congenital hypothyroidism is on the rise. To present the thyroid stimulating hormone screening results in babies born to hypothyroid mothers and assess the burden, aetiology of hypothyroidism in these babiesMethodsAll antenatal mothers attending our hospital during the study period were enrolled into the study. Group I includes 249 term babies born to hypothyroid mothers and group II comprises 2154 newborns born to mothers who are euthyroid. Heel prick thyroid stimulating hormone was done for all newborns on day 3 for both groups. Confirmatory venous testing was done for all for babies in group I and screen positives belonging to group II. Evaluation and therapy done as per standard guidelines.ResultsThyroid stimulating hormone values in the two groups are presented. There was significant correlation between peak maternal thyroid stimulating hormone and neonatal day 3 heel prick in group I (r=0.7, P<0.05). The prevalence of positive screening test in groups I and II was 3.8 and 1.03% (p<0.05) whereas corresponding values for confirmed disease was 4.3 and 0.6%, respectively (p<0.05). Aetiological evaluation revealed both transient hypothyroidism (33.3%) and permanent hypothyroidism (66.6%).Conclusion4.3% of babies born to hypothyroid mothers develop congenital hypothyroidism; aetiology being both transient and permanent. A venous test by 3 weeks is helpful in these babies to improve case identification.

Maternal Thyroid Status and the Incidence of Respiratory Distress Syndrome: Evaluation of a Proposed Relationship

PEDIATRICS ◽  
1975 ◽  
Vol 55 (4) ◽  
pp. 497-499
Author(s):  
Richard M. Cowett ◽  
Leo Stern
Keyword(s):  
Thyroid Hormones ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Retrospective Analysis ◽  
Low Birthweight ◽  
Distress Syndrome ◽  
Thyroid Status ◽  
Thyroid Activity ◽  
Fetal Thyroid ◽  
Maternal Thyroid

In order to establish whether maternal thyroid hormones cross the placenta and produce surfactant in the fetus, possibly reducing the incidence of respiratory distress syndrome (RDS), a retrospective analysis of low-birthweight infants was undertaken. Results indicate that maternal thyroid hormones play a negligible role and that any thyroid mediation would result from fetal thyroid activity.

Abnormal heart and great vessel development following acute ethanol exposure in mice

Teratology ◽  
1986 ◽  
Vol 33 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Paula A. Daft ◽  
Malcolm C. Johnston ◽  
Kathleen K. Sulik
Keyword(s):  
Ethanol Exposure ◽  
Great Vessel ◽  
Acute Ethanol ◽  
Vessel Development

scholarly journals Iron Deficiency Predicts Poor Maternal Thyroid Status during Pregnancy

2007 ◽  
Vol 92 (9) ◽  
pp. 3436-3440 ◽  
Author(s):  
Michael B. Zimmermann ◽  
Hans Burgi ◽  
Richard F. Hurrell
Keyword(s):  
Iron Deficiency ◽  
Thyroid Status ◽  
Maternal Thyroid

Changes of serum thyroid hormone levels induce malformations on early embryogenesis in rats

1989 ◽  
Vol 121 (5) ◽  
pp. 739-743 ◽  
Author(s):  
Seijiro Harakawa ◽  
Shoichi Akazawa ◽  
Mihoko Akazawa ◽  
Masumi Hashimoto ◽  
Shunichi Yamashita ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Normal Serum ◽  
Early Embryogenesis ◽  
Rat Embryo ◽  
Thyroid Status ◽  
Rat Serum ◽  
Fetal Malformations ◽  
Normal Rat ◽  
Maternal Thyroid ◽  
Rat Embryo Culture

Abstract. The incidence of malformation is increased in infants of hyperthyroid or hypothyroid woman. Although many papers reported that the fetus is insulted from maternal thyroid hormone, the placenta (maternalfetal barrier) is not yet fully developed before 11.5 days of gestation in rat embryos, suggesting the effect of thyroid hormone on early rat embryogenesis. This study was, therefore, undertaken to investigate whether excess or lack of thyroid hormones would affect early embryogenesis in rat embryo culture. Malformations including open neuropore and microencephaly were observed in 10 of 30 embryos incubated in hyperthyroid serum, and in 12 of 42 cultured in T3-enriched normal serum. Similar malformations were observed in 14 of 42 embryos cultured in hypothyroid serum and in 10 of 30 cultured in hypothyroid serum supplemented with T3. The frequencies of these malformations were significantly higher than in the control embryos (0 in 72 embryos) cultured with normal rat serum. These results suggest that the maternal thyroid status might play an important role for the complication of fetal malformations during early gestational period.

The rat placenta and the transfer of thyroid hormones from the mother to the fetus. Effects of maternal thyroid status.

Endocrinology ◽  
1992 ◽  
Vol 131 (1) ◽  
pp. 357-365 ◽  
Author(s):  
R Calvo ◽  
M J Obregón ◽  
F Escobar del Rey ◽  
G Morreale de Escobar
Keyword(s):  
Thyroid Hormones ◽  
Thyroid Status ◽  
Maternal Thyroid

scholarly journals Maternal thyroid status and its relation to ferritin and vitamin B12 in Saudi pregnant women

2019 ◽  
Vol 31 (2) ◽  
pp. 129
Author(s):  
MysaraMohamad Mogahed ◽  
EmanEl Sayed Amer ◽  
MonaAhmed El-Awady
Keyword(s):  
Vitamin B12 ◽  
Pregnant Women ◽  
Thyroid Status ◽  
Maternal Thyroid

scholarly journals Thyroid function and autoimmunity in Danish pregnant women after an iodine fortification program and associations with obstetric outcomes

2015 ◽  
Vol 173 (6) ◽  
pp. 709-718 ◽  
Author(s):  
Sofie Bliddal ◽  
Malene Boas ◽  
Linda Hilsted ◽  
Lennart Friis-Hansen ◽  
Ann Tabor ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Thyroid Function ◽  
Gestational Age ◽  
Thyroid Dysfunction ◽  
Reference Intervals ◽  
Obstetric Outcome ◽  
Thyroid Status ◽  
Antibody Positivity ◽  
Maternal Thyroid

ObjectiveAberrations in maternal thyroid function and autoimmunity during pregnancy have been associated with negative obstetric outcome. In Denmark, a national iodine fortification program was implemented in the year 2000 with the aim to alleviate the mild-moderate iodine deficiency. Following the iodine implementation, there has been an increase in thyroid autoimmunity in the background population. This study investigates the thyroid status of pregnant Danish women following the iodine fortification program, and a possible association with preterm delivery.DesignHistorical cohort study of 1278 randomly selected pregnant Danish women attending the national Down's syndrome screening program.MethodsThe main outcome measures were thyroid status according to laboratory- and gestational-age-specific reference intervals, and association with risk of abnormal obstetric outcome. Antibody-positivity was defined as an antibody-level (thyroid peroxidase and/or thyroglobulin antibodies) above 60 U/ml.ResultsEstablishing laboratory-specific gestational-age-dependent reference intervals, we found a prevalence of maternal thyroid dysfunction of 10%–15.8% by use of the cut-off suggested by the American Thyroid Association. Thyroid dysfunction was significantly associated with antibody-positivity (P<0.05). No associations were found between preterm delivery and thyroid dysfunction (adjusted OR 0.6, 95% CI: 0.1–2.3) or autoimmunity (adjusted OR 1.1, 95% CI: 0.4–2.7).ConclusionsAfter the implementation of the Danish iodine fortification program, the prevalence of thyroid dysfunction and autoimmunity in Danish pregnant women is high – even higher by use of pre-established reference intervals from international consensus guidelines. However, no associations were found with abnormal obstetric outcome. Large randomized controlled trials are needed to clarify the benefit of treating slight aberrations in pregnant women's thyroid function.

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