Impact of maternal thyroid disease on neonatal thyroid status

AbstractObjectivesPrevalence of Maternal and congenital hypothyroidism is on the rise. To present the thyroid stimulating hormone screening results in babies born to hypothyroid mothers and assess the burden, aetiology of hypothyroidism in these babiesMethodsAll antenatal mothers attending our hospital during the study period were enrolled into the study. Group I includes 249 term babies born to hypothyroid mothers and group II comprises 2154 newborns born to mothers who are euthyroid. Heel prick thyroid stimulating hormone was done for all newborns on day 3 for both groups. Confirmatory venous testing was done for all for babies in group I and screen positives belonging to group II. Evaluation and therapy done as per standard guidelines.ResultsThyroid stimulating hormone values in the two groups are presented. There was significant correlation between peak maternal thyroid stimulating hormone and neonatal day 3 heel prick in group I (r=0.7, P<0.05). The prevalence of positive screening test in groups I and II was 3.8 and 1.03% (p<0.05) whereas corresponding values for confirmed disease was 4.3 and 0.6%, respectively (p<0.05). Aetiological evaluation revealed both transient hypothyroidism (33.3%) and permanent hypothyroidism (66.6%).Conclusion4.3% of babies born to hypothyroid mothers develop congenital hypothyroidism; aetiology being both transient and permanent. A venous test by 3 weeks is helpful in these babies to improve case identification.

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Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China

Global Pediatric Health ◽

10.1177/2333794x14567193 ◽

2015 ◽

Vol 2 ◽

pp. 2333794X1456719 ◽

Cited By ~ 3

Author(s):

Xin Fan ◽

Shaoke Chen ◽

Jiale Qian ◽

Suren Sooranna ◽

Jingi Luo ◽

...

Keyword(s):

Newborn Screening ◽

Congenital Hypothyroidism ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

Who Guidelines ◽

Newborn Screening Program ◽

Study Results ◽

Stimulating Hormone

Background. A newborn screening program (NSP) for congenital hypothyroidism (CH) was carried out in Guangxi in order to understand the incidence of CH and the factors interrelated to major types of CH in this region of China. Methods. During 2009 to 2013, data from 930 612 newborns attending NSP in Guangxi were collected. Patients were classified with either permanent CH (PCH) or transient CH (TCH) after 2 years of progressive study. Results. A total of 1210 patients were confirmed with CH with an incidence of 1/769, including 68 PCH and 126 TCH cases with incidences of 1/6673 and 1/3385, respectively. The frequency of thyroid stimulating hormone values greater than 5 mIU/L was 7.2%, which, based on WHO guidelines, suggests that the population was mildly iodine deficient. Conclusions. The incidence of CH was high in Guangxi. Approximately two thirds of CH patients were TCH, which may be due to a deficiency in iodine within the population.

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Comparative analysis of the effectiveness of surgical techniques for the treatment of Miller Class I gingival recessions

Periodontology ◽

10.33925/1683-3759-2021-26-2-150-157 ◽

2021 ◽

Vol 26 (2) ◽

pp. 150-157

Author(s):

R. R. Farkhshatova ◽

L. P. Gerasimova ◽

I. T. Yunusov

Keyword(s):

Connective Tissue ◽

Soft Tissues ◽

Platelet Rich Plasma ◽

Class I ◽

Study Group ◽

Connective Tissue Graft ◽

Group I ◽

Autologous Platelet Rich Plasma ◽

Group Ii ◽

Autologous Platelet

Relevance. It is currently relevant to study and compare the effectiveness of the autologous connective tissue grafts and the combination of collagen-based and autologous platelet-rich plasma in the surgical treatment of Miller Class I gingival recessions.Materials and methods. We examined and treated 48 (20 male (41.67%) and 28 female (58.33%)) patients aged from 25 to 40 years with Miller Class I gingival recessions. All gingival recessions were treated surgically using a modified twolayer tunnel technique. The patients were divided into two groups according to the graft type. Group I (24 patients (50%) had a connective tissue graft from the hard palate. Group II (24 patients (50%) used the combination of the autologous platelet-rich plasma and 3D collagen matrix Fibromatrix for the regeneration of oral soft tissues. We removed the sutures on the 14th day. The patients were followed up on the 7th and 14th days and in 1.3 months.Results. 48 Miller Class I gingival recessions were treated between 2018 and 2020. The depth of gingival recessions averaged 3.5 ± 1.13 mm before treatment. The level of the attached keratinized gingiva regarding the cementoenamel junction significantly (p < 0.001) improved in both groups after the surgery. The width and thickness of the keratinized gingiva best increased in group II. The mean effectiveness of gingival recession treatment was 84% in study group I and 96% – in study group II. Pain syndrome, fibrinous plaque and soft tissue edema were insignificant in group II.Conclusion. The combination of the autologous platelet-rich plasma and Fibromatrix, collagen 3D matrix, for the regeneration of the oral soft tissues is a more effective technique for the treatment of Miller Class I gingival recessions. This technique has several advantages. It is minimally invasive, less painful, soft tissue postoperative swelling is less and the received volume of the attached keratinized gums is larger than with a connective tissue graft.

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Maternal education and newborn thyroid-stimulating hormone level in a congenital hypothyroidism screening program

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2018.1559809 ◽

2019 ◽

Vol 33 (16) ◽

pp. 2730-2734

Author(s):

Junhong Leng ◽

Ping Shao ◽

Shuang Zhang ◽

Nan Li ◽

Lei Pan ◽

...

Keyword(s):

Congenital Hypothyroidism ◽

Maternal Education ◽

Hormone Level ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Primary Thyroid Stimulating Hormone Screening for Congenital Hypothyroidism in King Abdullah Hospital, Bisha, Saudi Arabia

Cureus ◽

10.7759/cureus.7166 ◽

2020 ◽

Cited By ~ 1

Author(s):

Mohammed Abbas ◽

Eltayeb Tayrab ◽

Abedelmonium Elmakki ◽

Jowayria Tayrab ◽

Abdullah Al-shahrani ◽

...

Keyword(s):

Saudi Arabia ◽

Congenital Hypothyroidism ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Alphafetoprotein in screening for congenital hypothyroidism

Eastern Mediterranean Health Journal ◽

10.26719/2001.7.1-2.171 ◽

2001 ◽

Vol 7 (1-2) ◽

pp. 171-180

Author(s):

R. M. Shawky ◽

S. Abdel Fattah ◽

M. E. El Din Azzam ◽

M. M. Rafik ◽

A. Osman

Keyword(s):

Congenital Hypothyroidism ◽

Older Patients ◽

Thyroid Stimulating Hormone ◽

The Other ◽

Thyroid Status ◽

Term Neonates ◽

Significant Relationships ◽

The Mean ◽

Persistent Elevation

This study was conducted on 500 full-term neonates and 25 older patients with congenital hypothyroidism [CH], newly or previously diagnosed. Alphafetoprotein [AFP] was elevated in two neonates. In one, persistent elevation of AFP and thyroid stimulating hormone [TSH] with low thyroxine [T4] were found [congenital hypothyroidism]. In the other, AFP, TSH and T4 levels normalized [transient hypothyroidism]. The mean AFP level in new CH patients was significantly higher than in previously diagnosed patients, and was higher in CH patients than in controls. Significant relationships were found between AFP and T4, AFP and TSH, and AFP and age. AFP is a sensitive indicator of thyroid status and can be used as a screening test for hypothyroidism from the first day of life and in follow-up of CH patients.

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Screening for Hypothyroidism

PEDIATRICS ◽

10.1542/peds.72.2.263 ◽

1983 ◽

Vol 72 (2) ◽

pp. 263-264

Author(s):

Howard W. Kilbride ◽

Robert J. Lull ◽

Heinz G. Lehman

Keyword(s):

New England ◽

Congenital Hypothyroidism ◽

Human Error ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

The Past ◽

Cause Of Failure ◽

Stimulating Hormone

Although the New England Regional Screening Program report1 indicates that human error is the most likely cause of failure to detect congenital hypothyroidism in infants, our experience suggests that compensated hypothyroidism might be missed in some newborns unless screening includes a thyroid-stimulating hormone (TSH) assay and a thyroxine (T4) concentration. In the past 2 years, we have diagnosed congenital hypothyroidism in three infants. In at least one of these infants, the disease would not have been identified by T4 concentration screening alone.

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