Ultrafast 2,7-Naphthyridine-Based fluorescent probe for detection of thiophenol with a remarkable Stokes shift and its application In vitro and in vivo

Talanta ◽  
2019 ◽  
Vol 205 ◽  
pp. 120067 ◽  
Author(s):  
Rui Ren ◽  
Hong-Chuang Xu ◽  
Huan Dong ◽  
Hong-Tao Peng ◽  
Pan-Pan Wu ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Stokes Shift

scholarly journals Cancer-Specific Biomarker hNQO1-Activatable Fluorescent Probe for Imaging Cancer Cells In Vitro and In Vivo

Cancers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 470 ◽  
Author(s):  
Surendra Punganuru ◽  
Hanumantha Madala ◽  
Viswanath Arutla ◽  
Kalkunte Srivenugopal
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Stokes Shift ◽  
High Sensitivity ◽  
Cell Permeability ◽  
Quinone Oxidoreductase ◽  
Brain Tumor Cells ◽  
Sensitivity And Selectivity

Human NAD(P)H quinone oxidoreductase-1 (hNQO1) is an important cancer-related biomarker, which shows significant overexpression in malignant cells. Developing an effective method for detecting NQO1 activity with high sensitivity and selectivity in tumors holds a great potential for cancer diagnosis, treatment, and management. In the present study, we report a new dicyanoisophorone (DCP) based fluorescent probe (NQ-DCP) capable of monitoring hNQO1 activity in vitro and in vivo in both ratiometric and turn-on model. NQ-DCP was prepared by conjugating dicyanoisophorone fluoroprobe with hNQO1 activatable quinone propionic acid (QPA), which remain non-fluorescent until activation by tumor-specific hNQO1. NQ-DCP featured a large Stokes shift (145 nm), excellent biocompatibility, cell permeability, and selectivity towards hNQO1 allowed to differentiate cancer cells from healthy cells. We have successfully employed NQ-DCP to monitor non-invasive endogenous hNQO1 activity in brain tumor cells in vitro and in xenografted tumors developed in nude mice.

A novel near-infrared fluorescent probe with a large Stokes shift for biothiol detection and application in in vitro and in vivo fluorescence imaging

2017 ◽  
Vol 5 (21) ◽  
pp. 3836-3841 ◽  
Author(s):  
Keyin Liu ◽  
Huiming Shang ◽  
Xiuqi Kong ◽  
Weiying Lin
Keyword(s):  
Fluorescent Probe ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Stokes Shift ◽  
Large Stokes Shift ◽  
In Vivo Fluorescence ◽  
In Vivo Fluorescence Imaging

A novel near-infrared fluorescent probe with a large Stokes shift was developed for biothiol detection and application in in vitro and in vivo fluorescence imaging.

A novel colorimetric and near-infrared fluorescent probe for hydrogen peroxide imaging in vitro and in vivo

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85957-85963 ◽  
Author(s):  
Peng Wang ◽  
Ke Wang ◽  
Dan Chen ◽  
Yibo Mao ◽  
Yueqing Gu
Keyword(s):  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Near Infrared

A novel NIR fluorescent probe (DCM-B2) based on dicyanomethylene-4H-pyran was synthesized for the detection of H2O2.

A thiazolo[4,5-b]pyridine-based fluorescent probe for detection of zinc ions and application for in vitro and in vivo bioimaging

Talanta ◽  
2018 ◽  
Vol 185 ◽  
pp. 396-404 ◽  
Author(s):  
Jiao Gong ◽  
Yuan-heng Li ◽  
Chan-juan Zhang ◽  
Jian Huang ◽  
Qi Sun
Keyword(s):  
Fluorescent Probe ◽  
Zinc Ions

The development of a hemicyanine-based ratiometric CO fluorescent probe with a long emission wavelength and its applications for imaging CO in vitro and in vivo

2020 ◽  
Vol 44 (28) ◽  
pp. 12107-12112 ◽  
Author(s):  
Yunyan Zhang ◽  
Xiuqi Kong ◽  
Yonghe Tang ◽  
Min Li ◽  
Yaguang Yin ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Living Cells ◽  
Emission Wavelength ◽  
Long Wavelength ◽  
Wavelength Emission ◽  
Ratiometric Fluorescent Probe

A novel ratiometric fluorescent probe, Hcy-CO, with long-wavelength emission was developed for visualizing CO in living cells and zebrafish.

Highly sensitive and selective light-up fluorescent probe for monitoring gallium and chromium ions in vitro and in vivo

The Analyst ◽  
2019 ◽  
Vol 144 (12) ◽  
pp. 3807-3816 ◽  
Author(s):  
Xiaojun He ◽  
Chenglin Wu ◽  
Yuna Qian ◽  
Yahui Li ◽  
Lilei Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Chromium Ions ◽  
Highly Sensitive ◽  
Bio Imaging

Here reported an NBDT sensor could be effectively responsive to gallium and chromium for bio-imaging in vivo.

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