Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices

Talanta ◽  
2021 ◽  
pp. 123009
Author(s):  
Wael Talaat ◽  
Mohamed M.Y. Kaddah ◽  
Reda Mohammed Keshk
Keyword(s):  
Nucleoside Analogue ◽  
Dosage Form ◽  
Biological Matrices

scholarly journals Spectroscopic Estimation of Doxylamine Succinate in Tablets and Human Plasma by Formation of Ion-pair Complex

2021 ◽  
pp. 686-698
Author(s):  
Narender Malothu ◽  
Sowjanya Ravuri ◽  
Balakrishna Muthyala ◽  
Narayana Rao Alla ◽  
Anka Rao Areti
Keyword(s):  
Human Plasma ◽  
Dosage Form ◽  
Spectroscopic Method ◽  
Ion Pair ◽  
Biological Matrices ◽  
Short Analysis Time ◽  
Validation Criteria ◽  
Precise Analysis ◽  
Method Of Continuous Variation ◽  
Tablet Dosage

Aim: To develop a simple spectroscopic method for estimation of doxylamine (DOX) succinate in its tablet dosage form and human plasma with the aid of an ion-pair complex formation. Methods: In this method, methyl orange (0.05 % w/v) dye was used to form an ion-pair complex in acetate buffer (1M; pH: 5.00) at 300 C ± 20C. The ion-pair complex formed was extracted with chloroform. The maximum absorbance for the ion-pair complex was measured at 420 nm. Results and discussion: The method conditions were obeyed Beer's law in the concentrations ranging from 5-25 µg/mL of DOX succinate with a correlation coefficient (r2) of 0.992. The ion-pair (drug-dye) complex was formed in a 1:1 ratio which was demonstrated by Jobs' method of continuous variation. The method was satisfied the validation criteria as per ICH (Q2R1) guidelines. Accuracy studies showed 99.06-100.9 % recovery of the analyte. The responses of the precision and robustness were found within acceptable limits (<2% RSD). The LOD and LOQ values were found as 0.31 and 0.939 µg/mL, respectively. Conclusion: The developed method was simple, specific, and economical and requires a short analysis time. Therefore it could be considered for precise analysis of DOX succinate in biological matrices.

Significance of In-Vitro and In-Vivo Correlation in Drug Delivery System

2018 ◽  
Vol 4 (4) ◽  
pp. 523-531
Author(s):  
Hina Mumtaz ◽  
Muhammad Asim Farooq ◽  
Zainab Batool ◽  
Anam Ahsan ◽  
Ashikujaman Syed
Keyword(s):  
Dosage Form ◽  
Pharmaceutical Preparations ◽  
Pharmacokinetic Profile ◽  
In Vitro Dissolution ◽  
Time Saving ◽  
Pharmaceutical Dosage Form ◽  
Short Period ◽  
Form Development

The main purpose of development pharmaceutical dosage form is to find out the in vivo and in vitro behavior of dosage form. This challenge is overcome by implementation of in-vivo and in-vitro correlation. Application of this technique is economical and time saving in dosage form development. It shortens the period of development dosage form as well as improves product quality. IVIVC reduce the experimental study on human because IVIVC involves the in vivo relevant media utilization in vitro specifications. The key goal of IVIVC is to serve as alternate for in vivo bioavailability studies and serve as justification for bio waivers. IVIVC follows the specifications and relevant quality control parameters that lead to improvement in pharmaceutical dosage form development in short period of time. Recently in-vivo in-vitro correlation (IVIVC) has found application to predict the pharmacokinetic behaviour of pharmaceutical preparations. It has emerged as a reliable tool to find the mode of absorption of several dosage forms. It is used to correlate the in-vitro dissolution with in vivo pharmacokinetic profile. IVIVC made use to predict the bioavailability of the drug of particular dosage form. IVIVC is satisfactory for the therapeutic release profile specifications of the formulation. IVIVC model has capability to predict plasma drug concentration from in vitro dissolution media.

Comparative prevalence of prescription errors in randomly collected samples from hospital pharmacy and community pharmacy, Punjab, Pakistan

2017 ◽  
Vol 3 (3) ◽  
pp. 350-353
Author(s):  
Sabeeha Kausar ◽  
Muhammad Imran
Keyword(s):  
Patient Safety ◽  
Community Pharmacy ◽  
Hospital Pharmacy ◽  
Dosage Form ◽  
Physician Education ◽  
Prescribing Errors ◽  
Prescribing Practices ◽  
Prescription Errors ◽  
Dosing Frequency ◽  
N 93

Objective: This study was conducted to analyze and evaluate the prevalence of prescription errors, to optimize the medication effectiveness and patient safety and to encourage the rational prescribing practices. Method: sample of 250 prescriptions was randomly collected from outdoor hospital pharmacy (n=157) and from community pharmacy (n=93) and analyzed manually to estimate the prevalence of prescription errors. Results: Results calculated by using SPPS Version 23 and MS Excel 2013 are as follow; 41.4% prescription collected from outdoor hospital pharmacy presented significant prescribing errors while 54.7% in sample collected from community pharmacy. The prescriptions were segregated and errors were estimated using following parameters; dose, dosage form, dosing frequency, drug-drug interactions, spelling, and duplication of generic, therapy duration and unnecessary drugs. Conclusion: The prevalence of prescribing errors in sample of community pharmacy was 12.37% greater than found in prescriptions of hospital pharmacy. The prevalence of prescription errors can be reduced by physician education, using automated prescribing systems and immediate review of prescription by pharmacist before dispensing of prescription items to patients.

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