Water-acetic acid mediated an efficient and eco-friendly protocol for the one-pot synthesis of bis-isoxazolyl amino dihydro-1 H -indol-4(5 H )-ones under mild reaction conditions

2017 ◽  
Vol 58 (51) ◽  
pp. 4790-4795 ◽  
Author(s):  
Modugu Nagi Reddy ◽  
Pittala Praveen Kumar
Keyword(s):  
Acetic Acid ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

scholarly journals ZnO-beta zeolite mediated simple and efficient method for the one-pot synthesis of quinoxaline derivatives at room temperature

2010 ◽  
Vol 8 (2) ◽  
pp. 320-325 ◽  
Author(s):  
Santosh Katkar ◽  
Pravinkumar Mohite ◽  
Lakshman Gadekar ◽  
Balasaheb Arbad ◽  
Machhindra Lande
Keyword(s):  
Efficient Method ◽  
Room Temperature ◽  
Environmentally Benign ◽  
Beta Zeolite ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Quinoxaline Derivatives ◽  
The One ◽  
Work Up

AbstractA rapid and an efficient one-pot method for the synthesis of quinoxalines catalysed by ZnO-beta zeolite at room temperature is described. This environmentally benign method provides several advantages over methods that are currently employed such as a simple work-up, mild reaction conditions, good to excellent yields, and a process to recover and reuse the catalyst for several cycles with consistent activity.

Tributylhexadecylphosphonium bromide: an efficient reagent system for the one-pot synthesis of 2,4,5-trisubstituted imidazoles

2015 ◽  
Vol 21 (2) ◽  
Author(s):  
Mohammad Heidari ◽  
Mohsen Rezaei ◽  
Rashid Badri
Keyword(s):  
Cost Effectiveness ◽  
Aromatic Aldehyde ◽  
Ammonium Acetate ◽  
Reaction Times ◽  
Environmentally Benign ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Efficient Reagent

AbstractThe reaction of benzil, an aromatic aldehyde, and ammonium acetate in ethanol at reflux in the presence of tributylhexadecylphosphonium bromide as catalyst affords a 2,4,5-trisubstituted imidazole. The present methodology offers several advantages over the literature methods, including excellent yields, shorter reaction times, environmentally benign milder reaction conditions, cost-effectiveness of catalyst, easy workup, and purification of products by nonchromatographic methods.

scholarly journals Acetic Acid Catalysed One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives

Synlett ◽  
2019 ◽  
Vol 30 (19) ◽  
pp. 2148-2152
Author(s):  
Pia N. M. Allan ◽  
Martyna I. Ostrowska ◽  
Bhaven Patel
Keyword(s):  
Acetic Acid ◽  
Air Oxidation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Catalysed Reaction ◽  
Quinoxaline Derivatives ◽  
Reaction Proceeds ◽  
The One

An efficient acetic acid catalysed reaction has been developed for the synthesis of 4-aryl substituted pyrrolo[1,2-a]quinoxalines from readily available starting materials. A range of structures have been synthesised in very good to excellent yields. The one-pot reaction proceeds through imine formation, cyclisation followed by air oxidation.

2-Phenyl-2,3-dihydrobenzo[d]thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water

Synlett ◽  
2017 ◽  
Vol 29 (04) ◽  
pp. 477-482 ◽  
Author(s):  
Dibakar Deka ◽  
Subarna Kalita
Keyword(s):  
Reducing Agent ◽  
High Yield ◽  
Purification Process ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Highly Active ◽  
The One ◽  
Operational Simplicity

A metal- and catalyst-free reductive alkylation protocol for the one-pot synthesis of 5-monoalkylbarbiturates from barbituric acids and aldehydes using the in situ generated chemoselective reducing agent 2-phenyl-2,3-dihydrobenzo[d]thiazole from 2-aminothiophenol and benzaldehyde is described. The notable advantages of the protocol are operational simplicity, mild reaction conditions, high yield, short reaction time, and simple workup and purification process which make it highly attractive.

CuO Nanoparticles: A Mild and Efficient Reusable Catalyst for the One-Pot Synthesis of 4-amino-5-pyrimidinecarbonitriles under Aqueous Conditions

2012 ◽  
Vol 326-328 ◽  
pp. 372-376
Author(s):  
Seyed Javad Ahmadi ◽  
Sodeh Sadjadi ◽  
Morteza Hosseinpour
Keyword(s):  
Efficient Method ◽  
Reaction Times ◽  
Cuo Nanoparticles ◽  
Reusable Catalyst ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
The One ◽  
Aqueous Conditions

An efficient method for the synthesis of 4-amino-5-pyrimidinecarbonitriles by three-component reaction of malononitrile, aldehydes and N-unsubstituted amidines, under aqueous conditions, using CuO nanoparticles as catalyst is reported. The protocol offers advantages in terms of higher yields, short reaction times, and mild reaction conditions, with reusability of the catalyst.

An expedient and convenient approach for one-pot synthesis of 1H-isoindole-1,3(2H)-diones

2016 ◽  
Vol 71 (9) ◽  
pp. 941-944 ◽  
Author(s):  
Zeinab Ekhtiari ◽  
Forugh Havasi ◽  
Farzad Nikpour
Keyword(s):  
Nitrogen Source ◽  
Guanidinium Chloride ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Convenient Approach ◽  
Cyclic Anhydrides ◽  
The One

AbstractAn easy and expedient method for the one-pot synthesis of 1H-isoindole-1,3(2H)-diones has been developed by the reaction of the corresponding cyclic anhydrides with guanidinium chloride as a nitrogen source in the presence of FeCl3 as a catalyst under mild reaction conditions.

scholarly journals Synthesis and Properties of Partially Hydrogenated Ethyl ([3,4']Bipyridin-6'-ylsulfanyl) Acetates

2010 ◽  
Vol 49 (1-4) ◽  
pp. 66-71
Author(s):  
A. Krauze ◽  
Z. Andžāns ◽  
G. Duburs
Keyword(s):  
Acetic Acid ◽  
Synthesis Method ◽  
Subsequent Treatment ◽  
Ethyl Bromoacetate ◽  
One Pot ◽  
Cardiovascular Agents ◽  
One Pot Synthesis ◽  
The One

Synthesis and Properties of Partially Hydrogenated Ethyl ([3,4']Bipyridin-6'-ylsulfanyl) Acetates Ethyl 2'-hydroxy-1',2',3',4'-tetrahydro[3,4']bipyridine-3'-carboxylate 3 and the corresponding ethyl 1',4'-dihydro[3,4']bipyridine-3'-carboxylate 4 as potential cardiovascular agents have been prepared by alkylation of 2'-hydroxy-1',2',3',4'-tetrahydro[3,4']bipyridine-6'-thiolate 1 or betaine 2 with ethyl bromoacetate. The treatment of [3,4']bipyridine 4 with KOH/H2O gave diethyl 3-amino-4-(pyridin-3-yl)-4,7-dihydrothieno[2,3-b]-pyridine-2,5-dicarboxylate 5, but subsequent treatment of the remaining reaction mixture with acetic acid excess gave ethyl 3-oxo-7-(pyridin-3-yl)-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6-carboxylate 7 - the product of intramolecular acylation. Compounds 4, 5 and 7 have been prepared using the one-pot synthesis method. Alkylation of [3,4']bipyridine 4 with iodomethane gave 1',4'-dihydro[3,4'] bipyridin-1-ium iodide 8.

ChemInform Abstract: Ammonium Nitrate in Acetic Acid, an Efficient Reagent for the Nitration of Perimidines and the One-Pot Synthesis of 6(7)-Aminoperimidines.

ChemInform ◽  
2011 ◽  
Vol 42 (52) ◽  
pp. no-no
Author(s):  
A. V. Aksenov ◽  
A. S. Lyakhovnenko ◽  
T. S. Perlova ◽  
I. V. Aksenova
Keyword(s):  
Acetic Acid ◽  
Ammonium Nitrate ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Efficient Reagent

Ammonium nitrate in acetic acid, an efficient reagent for the nitration of perimidines and the one-pot synthesis of 6(7)-aminoperimidines

2011 ◽  
Vol 47 (2) ◽  
pp. 245-246 ◽  
Author(s):  
A. V. Aksenov ◽  
A. S. Lyakhovnenko ◽  
T. S. Perlova ◽  
I. V. Aksenova
Keyword(s):  
Acetic Acid ◽  
Ammonium Nitrate ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Efficient Reagent

Two Efficient One-Pot Approaches for Regioselective Synthesis of New 3-Arylpyridazino[4,3-c]quinolin-5(6H)-ones

2015 ◽  
Vol 68 (10) ◽  
pp. 1529 ◽  
Author(s):  
Mehdi Rimaz
Keyword(s):  
Hydrazine Hydrate ◽  
Regioselective Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
The One ◽  
High Yields ◽  
Arylglyoxal Monohydrates ◽  
Operational Simplicity

Two efficient regioselective approaches for the one-pot synthesis of 3-arylpyridazino[4,3-c]quinolin-5(6H)-one derivatives are reported, by the three-component reaction of arylglyoxal monohydrates, quinoline-2,4-diol, and hydrazinium dihydrochloride or hydrazine hydrate in ethanol and pyridine. In ethanol, the reactions were catalyzed by 1,4-diazobicyclo[2,2,2]octane. The features of both procedures are high regioselectivity, mild reaction conditions, good to high yields, and operational simplicity.

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