Insulin resistance causes impaired vasodilation and hypofibrinolysis in young women with polycystic ovary syndrome

Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous disorder and associated with metabolic disturbances such as insulin resistance (IR) and obesity which are risk factors for cardiovascular diseases. Many studies have shown that waist circumference (WC) representing abdominal obesity is an important risk factor for IR. However, there were few studies whether WC were associated with IR in young women with PCOS. We aimed to evaluate the role of WC in IR among young Korean women with PCOS. We enrolled age- and body mass index-matched women with PCOS (n = 100) and controls (n = 100). WC was measured and the 75-gram oral glucose tolerance test (OGTT) was performed. Insulin sensitivity was assessed by the Stumvoll index which was calculated from an OGTT. Multiple linear regression analysis was performed to evaluate the association between WC and IR. WC, fasting glucose, post-load 2-hour glucose, fasting insulin, and post-load 2-hour insulin did not differ between women with PCOS and controls. Women with PCOS had lower values of the Stumvoll index than the controls. In correlation analysis, WC was negatively correlated with the Stumvoll index in women with PCOS, however not in controls. In multiple regression analysis, WC was negatively associated with the Stumvoll index even after adjustment for age, total cholesterol, and total testosterone in women with PCOS. In young Korean women with PCOS, WC was negatively associated with insulin sensitivity independent of hyperandrogenemia. Simply measuring of WC could be used to screen the high risk group having IR in young women with PCOS.

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Hyperhomocysteinemia, insulin resistance and body mass index in Iranian young women with polycystic ovary syndrome

Middle East Fertility Society Journal ◽

10.1016/j.mefs.2017.01.007 ◽

2017 ◽

Vol 22 (2) ◽

pp. 149-155 ◽

Cited By ~ 3

Author(s):

Sedigheh Esmaeilzadeh ◽

Eisa Tahmasbpour ◽

Maryam Gholinezhad-Chari

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Young Women ◽

Polycystic Ovary ◽

Ovary Syndrome

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Bone Mineral Density is Unaltered in Women with Polycystic Ovary Syndrome

Hormone and Metabolic Research ◽

10.1055/a-0733-7768 ◽

2018 ◽

Vol 50 (10) ◽

pp. 754-760 ◽

Cited By ~ 2

Author(s):

Mohd Ganie ◽

Semanti Chakraborty ◽

Ashish Sehgal ◽

M. Sreejith ◽

Devasenathipathy Kandasamy ◽

...

Keyword(s):

Bone Mineral Density ◽

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Bone Mineral ◽

Young Women ◽

Polycystic Ovary ◽

Oral Glucose ◽

Model Assessment ◽

Mineral Density ◽

Ovary Syndrome

Abstract Context The effects of endocrine aberrations associated with polycystic ovary syndrome (PCOS) on bone mineral density (BMD) in young women is a matter of debate. Objectives To compare BMD in young women with PCOS to age and body mass index (BMI) matched controls and to elucidate its correlation to BMI, insulin resistance and serum testosterone. Design and Methods We recruited 60 women with PCOS aged 14-24 years, diagnosed based on Rotterdam 2003 criteria, and 58 age matched controls. BMD was measured by dual energy X-ray absorptiometry. In addition, these subjects underwent biochemical and hormonal analysis including oral glucose tolerance test, calculation of Homeostatic Model Assessment–Insulin Resistance Index, measurement of serum thyroxine, thyrotropin, prolactin, total testosterone, dehydroepiandrosterone sulfate, follicular phase luteinizing hormone and follicle stimulating hormone. Results There was no difference of BMD between women with PCOS and control women (1.103±0.08 vs 1.126±0.083 g/cm2; p=0.122). In subgroup analysis based on BMI, BMD in obese women with PCOS was significantly higher than their overweight and lean counterparts at lumbar spine (p<0.001), neck of femur (p=0.005) and total hip (p<0.001). BMD was not different at any site between oligomenorrheic and non-oligomenorrheic women with PCOS. It positively correlated with BMI, waist and hip circumference in women with PCOS. No correlation was found with HOMA-IR or Testosterone. Conclusions BMI is the most important determinant of BMD in women with PCOS. BMD is not different between healthy young women and those with PCOS.

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