Incidence of Ct scan-detected pulmonary embolism in patients with oncogene-addicted, advanced lung adenocarcinoma

2015 ◽  
Vol 136 (5) ◽  
pp. 924-927 ◽  
Author(s):  
Melina Verso ◽  
Rita Chiari ◽  
Stefano Mosca ◽  
Laura Franco ◽  
Matthias Fischer ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Lung Adenocarcinoma ◽  
Ct Scan

scholarly journals Pericardial tamponade and coexisting pulmonary embolism as first manifestation of non-advanced lung adenocarcinoma

2014 ◽  
Vol 18 ◽  
Author(s):  
Salwa Akhbour ◽  
Brahim Amine Khennine ◽  
Latifa Oukerraj ◽  
Jamila Zarzur ◽  
Mohamed cherti
Keyword(s):  
Pulmonary Embolism ◽  
Lung Adenocarcinoma ◽  
Pericardial Tamponade

scholarly journals Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism

2021 ◽  
Vol 5 (8) ◽  
pp. 2237-2244
Author(s):  
Parth Patel ◽  
Payal Patel ◽  
Meha Bhatt ◽  
Cody Braun ◽  
Housne Begum ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Ct Scan ◽  
Major Bleeding ◽  
Meta Analysis ◽  
Cochrane Central Register ◽  
Suspected Pulmonary Embolism ◽  
Central Register ◽  
Mortality Incidence ◽  
D Dimer

Abstract Prompt evaluation and therapeutic intervention of suspected pulmonary embolism (PE) are of paramount importance for improvement in outcomes. We systematically reviewed outcomes in patients with suspected PE, including mortality, incidence of recurrent PE, major bleeding, intracranial hemorrhage, and postthrombotic sequelae. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for eligible studies, reference lists of relevant reviews, registered trials, and relevant conference proceedings. We included 22 studies with 15 865 patients. Among patients who were diagnosed with PE and discharged with anticoagulation, 3-month follow-up revealed that all-cause mortality was 5.69% (91/1599; 95% confidence interval [CI], 4.56-6.83), mortality from PE was 1.19% (19/1597; 95% CI, 0.66-1.72), recurrent venous thromboembolism (VTE) occurred in 1.38% (22/1597; 95% CI: 0.81-1.95), and major bleeding occurred in 0.90% (2/221%; 95% CI, 0-2.15). In patients with a low pretest probability (PTP) and negative D-dimer, 3-month follow-up revealed mortality from PE was 0% (0/808) and incidence of VTE was 0.37% (4/1094; 95% CI: 0.007-0.72). In patients with intermediate PTP and negative D-dimer, 3-month follow-up revealed that mortality from PE was 0% (0/2747) and incidence of VTE was 0.46% (14/3015; 95% CI: 0.22-0.71). In patients with high PTP and negative computed tomography (CT) scan, 3-month follow-up revealed mortality from PE was 0% (0/651) and incidence of VTE was 0.84% (11/1302; 95% CI: 0.35-1.34). We further summarize outcomes evaluated by various diagnostic tests and diagnostic pathways (ie, D-dimer followed by CT scan).

scholarly journals Successful retreatment with osimertinib after osimertinib-induced acute pulmonary embolism in a patient with lung adenocarcinoma: A case report

2017 ◽  
Vol 20 ◽  
pp. 25-27 ◽  
Author(s):  
Takayuki Shiroyama ◽  
Manabu Hayama ◽  
Shingo Satoh ◽  
Shingo Nasu ◽  
Ayako Tanaka ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Case Report ◽  
Lung Adenocarcinoma ◽  
Acute Pulmonary Embolism

scholarly journals Nonbacterial Thrombotic Endocarditis and Widespread Skin Necrosis in Newly Diagnosed Lung Adenocarcinoma

2020 ◽  
Vol 13 (1) ◽  
pp. 239-244 ◽  
Author(s):  
Katerina Zakka ◽  
Patrick Zakka ◽  
Amir Davarpanah ◽  
Nikoloz Koshkelashvili ◽  
Mehmet A. Bilen ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Lung Adenocarcinoma ◽  
Ct Scan ◽  
Metastatic Disease ◽  
Skin Lesions ◽  
Primary Adenocarcinoma ◽  
Neoplastic Disease ◽  
Lung Field ◽  
Nonbacterial Thrombotic Endocarditis ◽  
Hands And Feet

Nonbacterial thrombotic endocarditis (NBTE) is a rare entity most commonly diagnosed postmortem with rates in autopsy series ranging from 0.9 to 1.6%. A 63-year-old female with past medical history of hypertension and mitral valve prolapse presented to the hospital with shortness of breath, headache, and necrotic skin lesions on her hands and feet. Computed tomography (CT) scan of her chest demonstrated a pulmonary embolus in the right lower lung segmental artery and right upper lobe lobar to segmental pulmonary artery, a mass-like consolidation in the left upper lung field impeding the hilum. CT scan of the abdomen demonstrated metastatic disease in liver and bone and bilateral femoral deep vein thrombosis. Transesophageal echocardiography revealed severe mitral regurgitation with two small mobile plaques on the mitral valve and two immobile plaques on the descending aorta. Magnetic resonance imaging of the brain was consistent with subacute infarcts and metastatic disease. Bronchoscopy was performed and pathology revealed primary adenocarcinoma of the lung. She was treated with anticoagulation and systemic chemotherapy. The patient and family elected to proceed with hospice due to her clinical decline, poor performance status, and poor prognosis after a prolonged hospital stay. Underlying malignancy is detected in approximately 40–85% of patients with NBTE. Lung cancer is the most frequently associated malignancy followed by pancreatic, stomach, breast, and ovarian cancer. Widespread necrotic skin lesions as presenting symptoms of primary lung adenocarcinoma are rare. In the present case, the diagnosis of necrotic skin lesions and NBTE preceded that of the neoplastic disease. Necrotic skin lesions and NBTE can be the first manifestations of an occult malignancy causing extensive multi-organ infarcts. NBTE can present with such extensive skin lesions as a first presenting sign of malignancy. To the best of our knowledge, this is the first case to present with such extensive skin lesions as the first presenting symptom of lung adenocarcinoma.

Post-mortem CT scan with contrast injection and chest compression to diagnose pulmonary embolism

2014 ◽  
Vol 41 (1) ◽  
pp. 167-168 ◽  
Author(s):  
Claire Pichereau ◽  
Eric Maury ◽  
Laurence Monnier-Cholley ◽  
Simon Bourcier ◽  
Gabriel Lejour ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Ct Scan ◽  
Chest Compression ◽  
Post Mortem ◽  
Contrast Injection

scholarly journals EGFR-Mutant Lung Adenocarcinoma Mimicking a Pneumonia

2012 ◽  
Vol 2012 ◽  
pp. 1-2
Author(s):  
Álvaro Taus ◽  
Flavio Zuccarino ◽  
Carlos Trampal ◽  
Edurne Arriola
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Ct Scan ◽  
Kinase Inhibitor ◽  
Specific Treatment ◽  
Diagnostic Errors ◽  
Pet Ct ◽  
Egfr Mutant ◽  
Histological Confirmation ◽  
Pet Ct Scan

PET-CT scan has demonstrated to be very effective in lung cancer diagnosis and staging, but lung cancer has multiple ways of presentation, which can lead to an error in diagnosis imaging and a delay on the beginning of specific treatment. We present a case of a 77-year-old man with an initial PET-CT scan showing high 18F-FDG intake, suggesting a bilateral pneumonia, who was finally diagnosed of an EGFR-mutant lung adenocarcinoma. EGFR-activating mutation allowed us to start treatment with the oral tyrosin kinase inhibitor Gefitinib, obtaining a rapid and sustained response. Histological confirmation of imaging findings is always necessary to avoid diagnostic errors.

scholarly journals P690 Pulmonary valve endocarditis complicated with fistula between right ventricle outflow tract and aorta in a patient with patent ductus arteriosus

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
D Toader ◽  
A Craciun Mirescu ◽  
M Cocora ◽  
O Munteanu ◽  
E R Mustafa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Infective Endocarditis ◽  
Patent Ductus Arteriosus ◽  
Right Ventricle ◽  
Ct Scan ◽  
Pulmonary Valve ◽  
Ductus Arteriosus ◽  
Signs And Symptoms ◽  
Patent Ductus

Abstract Background The majority of cases of right sided infective endocarditis involve the tricuspid valve. Isolated pulmonary valve (PV) endocarditis is rare. Congenital heart disease are risk factors. Material and methods: We present the case of 36 years old male, without any known cardiovascular disease, who was admitted with signs and symptoms of heart failure, pulmonary embolism and fever. He was evaluated clinically, 12 lead ECG, pulmonary radiography, thoracic computer tomography (CT) scan, transthoracic and transesophageal echocardiography, laboratory investigations. Results: Transthoracic and transesophageal echocardiogram revealed large vegetations located on pulmonary valve, pulmonary regurgitation and dilation of the pulmonary valve, patent ductus arteriosus (PDA) with bidirectional shunt and local complications: fistula between right ventricle outflow tract (RVOT) and aorta, pleural and pericardial effusion. Blood cultures were negative. ECG aspect was right bundle branch block. Radiography and thoracic CT scan revealed pulmonary embolism aspect. The patient was treated with antibiotics and surgical option included debridement of the infected area, vegetation excision with valve replacement, relief of RVOT, fistula closure with pericardial patch and ligature of PDA. Evolution after surgical intervention was good.Conclusions: This presentation reveals a favorable evolution of a patient with infective endocarditis located to pulmonary valve. In most of cases, right heart endocarditis presents with signs and symptoms of respiratory disease and fever; these are due to septic pulmonary embolization. Isolated PV endocarditis still remains a challenging and needs carefully echocardiographic evaluation for a correct diagnosis and risk factors identification.

scholarly journals Surgical Treatment in a High-Risk Pulmonary Embolism: Case Report

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 725
Author(s):  
Horatiu Moldovan ◽  
Andra-Madalina Sibisan ◽  
Robert Tiganasu ◽  
Elena Nechifor ◽  
Daniela Gheorghita ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
High Risk ◽  
Ct Scan ◽  
Preoperative Evaluation ◽  
Hemodynamic Instability ◽  
Pulmonary Embolectomy ◽  
Vein Thrombosis ◽  
Severe Hypotension ◽  
Lower Limb Pain ◽  
The Right

We present the case of a 35-year-old woman who had a high-risk pulmonary embolism (according to ESC risk stratification for pulmonary embolism) after she had undergone a Caesarion section. Postoperatively, she presented with acute left lower limb pain, swelling and erythema. A diagnosis was made of deep vein thrombosis (DVT) of the ilio-femoral and popliteal veins. She was started on anticoagulant therapy, which proved to be inefficient, the patient developing a left calf and thigh oedema and shortness of breath. A CT scan revealed high-risk embolus located in the right atrium and through the tricuspid valve. The decision was made to refer her to a cardiovascular surgeon. During her preoperative evaluation, the patient became hemodynamically unstable and was rushed into the operating room, severely desaturated, bradycardic, without consciousness, with severe hypotension. On the basis of the severe state of the patient and the CT scan findings we performed an emergency pulmonary embolectomy, with the patient on cardio-pulmonary by-pass, without cross-clamping the aorta, using a modified Trendelenburg procedure. This case supports using open pulmonary embolectomy for patients with hemodynamic instability on the basis of clinical diagnosis.

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