Caco-2/TC7 cell line characterization for intestinal absorption: How reliable is this in vitro model for the prediction of the oral dose fraction absorbed in human?

2011 ◽  
Vol 25 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Laura Turco ◽  
Tiziana Catone ◽  
Francesca Caloni ◽  
Emma Di Consiglio ◽  
Emanuela Testai ◽  
...  
1996 ◽  
Vol 24 (4) ◽  
pp. 581-587
Author(s):  
Cristiana Zanetti ◽  
Arrnalaura Stammati ◽  
Orazio Sapora ◽  
Flavia Zucco

The aim of this study was to investigate the endpoints related to cell death, either necrosis or apoptosis, induced by four chemicals in the promyelocytic leukemia cell line, HL-60. Cell morphology, DNA fragmentation, cytofluorimetric analysis and oxygen consumption were used to classify the type of cell death observed. In our analysis, we found that not all the selected parameters reproduced the differences observed in the cell death caused by the four chemicals tested. As cell death is a very complex phenomenon, several factors should be taken into account (cell type, exposure time and chemical concentration), if chemicals are to be classified according to differences in the mechanisms more directly involved in cell death.


Phytomedicine ◽  
2008 ◽  
Vol 15 (5) ◽  
pp. 373-377 ◽  
Author(s):  
B. Waltenberger ◽  
B. Avula ◽  
M. Ganzera ◽  
I.A. Khan ◽  
H. Stuppner ◽  
...  

2016 ◽  
Vol 53 ◽  
pp. 74
Author(s):  
Claudio Alvarez ◽  
Paula Santana ◽  
Francisco Donoso ◽  
Felipe Ramírez ◽  
Jimena Cortés ◽  
...  

2020 ◽  
Vol 140 ◽  
pp. 111331 ◽  
Author(s):  
Diomira Luongo ◽  
Lucia Treppiccione ◽  
Francesco Maurano ◽  
Mauro Rossi ◽  
Paolo Bergamo
Keyword(s):  

2020 ◽  
Vol 8 (2) ◽  
pp. 1748459 ◽  
Author(s):  
Grace C. Lin ◽  
Tamara Leitgeb ◽  
Alexandra Vladetic ◽  
Heinz-Peter Friedl ◽  
Nadine Rhodes ◽  
...  

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