Simultaneous screening of the stability and dosimetry of nanoparticles dispersions for in vitro toxicological studies with static multiple light scattering technique

2020 ◽  
Vol 69 ◽  
pp. 104972
Author(s):  
Matthias P.L. Sentis ◽  
Giovanni Brambilla ◽  
Valérie Fessard ◽  
Gérard Meunier
2007 ◽  
Vol 101 (2) ◽  
pp. 239-253 ◽  
Author(s):  
Richard C. Murdock ◽  
Laura Braydich-Stolle ◽  
Amanda M. Schrand ◽  
John J. Schlager ◽  
Saber M. Hussain

2006 ◽  
Vol 20 (2) ◽  
pp. 57-66 ◽  
Author(s):  
Igor V. Mindukshev ◽  
Nikolay V. Goncharov ◽  
Elena Yu. Shabanova ◽  
Elena E. Ermolaeva ◽  
Maria O. Mironova ◽  
...  

A new method for studying platelets based on low-angle light scattering has previously revealed that platelets taken from pregnant women with preeclampsia are hypersensitive to ADP, with aggregation developing at concentrations of 7–15 nmol l−1. The method has been applied to further studies in experimental toxicology and clinical pathology. Toxicological experiments with fluoroacetate (FA), an inhibitor of TCA cycle, showed that the platelet hypersensitivity could also be caused by energy depletion. In modeling experiments, the low-angle light scattering method was applied to assessment of potential corrective agents of the pathological states related to hypersensitivity of platelets. Sodium glutamate (SG) was shown to be a potent antiaggregantin vitro, and subsequentin vivostudies demonstrated that SG can apparently serve as anaplerotic agent and normalize the platelet status of rats intoxicated with FA. Donators of nitric oxide (NO), such as isosorbide-5′-dinitrate, can also normalizein vitrothe hypersensitive status of platelets taken from the patients with preeclampsia.


Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1582
Author(s):  
Mohsen Ramezani ◽  
Giovanna Ferrentino ◽  
Ksenia Morozova ◽  
Matteo Scampicchio

The present paper investigates the use of multiple light scattering for the monitoring of milk fermentation. The experiments were performed on milk fermented with different starter concentrations (0.05% to 4.5% (w/w) at temperatures from 36 to 44 °C and in the presence of antibiotics at concentrations up to 100 µg/kg. The fermentation was monitored continuously by using a multiple light scattering technique and simultaneously by a pH meter, a rheometer and a texture analyzer. The backscattering signal recorded by multiple light scattering measurements was correlated with the changes in pH, rheological parameters and firmness of the samples along the fermentation. A gelation time of 120 min was obtained when the highest concentration of starter (4.5%, w/w) and incubation temperature of 44 °C were used. These results were confirmed by the pH, rheological and texture monitoring. The analysis of backscattering spectra allowed the detection of the effect of antibiotic on the gel formation even at low concentrations (1.3 µg/kg). Overall, the results highlighted the advantages of using a multiple light scattering technique as quality control tool for online monitoring of milk fermentation.


2004 ◽  
Author(s):  
Hiromasa Suzuki ◽  
Takamitsu Okumura ◽  
Akihiro Tagaya ◽  
Eizaburo Higuchi ◽  
Yasuhiro Koike

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