Perinatal exposure to known endocrine disrupters alters ovarian development and systemic steroid hormone profile in rats

The ovaries play a critical role in female reproductive health because they are the site of oocyte maturation and sex steroid hormone production. The unique cellular processes that take place within the ovary make it a susceptible target for chemical mixtures. Herein, we review the available data regarding the effects of chemical mixtures on the ovary, focusing on development, folliculogenesis, and steroidogenesis. The chemical mixtures discussed include those to which women are exposed to environmentally, occupationally, and medically. Following a brief introduction to chemical mixture components, we describe the effects of chemical mixtures on ovarian development, folliculogenesis, and steroidogenesis. Further, we discuss the effects of chemical mixtures on corpora lutea and transgenerational outcomes. Identifying the effects of chemical mixtures on the ovaries is paramount to preventing and treating mixture-inducing toxicity of the ovary that has long-term consequences such as infertility and ovarian disease.

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Steroid hormone profile of canine inflammatory mammary carcinoma: a preliminary study

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/s0960-0760(03)00030-x ◽

2003 ◽

Vol 84 (2-3) ◽

pp. 211-216 ◽

Cited By ~ 23

Author(s):

L Peña ◽

G Silván ◽

M.D Pérez-Alenza ◽

A Nieto ◽

J.C Illera

Keyword(s):

Mammary Carcinoma ◽

Steroid Hormone ◽

Hormone Profile ◽

Preliminary Study

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Plasma steroid hormone profile in an anovulatory Arctic charr, Salvelinus alpinus (L.), exhibiting ovarian cysts

Journal of Fish Diseases ◽

10.1046/j.1365-2761.1996.d01-88.x ◽

1996 ◽

Vol 19 (5) ◽

pp. 389-394 ◽

Cited By ~ 1

Author(s):

M N Khan ◽

R Renaud ◽

J F Leatherland

Keyword(s):

Salvelinus Alpinus ◽

Arctic Charr ◽

Steroid Hormone ◽

Ovarian Cysts ◽

Hormone Profile

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Steroid hormone profile in postmenopausal women with ovarian cancer

European Journal of Cancer ◽

10.1016/0959-8049(94)90414-6 ◽

1994 ◽

Vol 30 (4) ◽

pp. 442-445 ◽

Cited By ~ 6

Author(s):

M.E.R. O'Brien ◽

M. Dowsett ◽

I. Fryatt ◽

E. Wiltshaw

Keyword(s):

Ovarian Cancer ◽

Postmenopausal Women ◽

Steroid Hormone ◽

Hormone Profile

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Changes in Plasma and Ovarian Steroid Hormone Level in Wild Female Blue Tang Fish Paracanthurus hepatus during a Reproductive Cycle

Animals ◽

10.3390/ani9110889 ◽

2019 ◽

Vol 9 (11) ◽

pp. 889

Author(s):

Huynh Sang ◽

Ho Lam ◽

Le Hy ◽

Pham Ky ◽

Phan Minh-Thu

Keyword(s):

Significant Role ◽

Seasonal Cycle ◽

Ovarian Development ◽

Hormone Level ◽

Steroid Hormone ◽

Gonadosomatic Index ◽

Wild Populations ◽

Wild Female ◽

Steroid Hormone Level ◽

Estradiol 17Β

This study aimed to document the seasonal cycle of steroid levels in the plasma and ovary, including testosterone (T), estradiol-17β (E2) and 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) in relation to ovarian development in wild populations of female blue tang fish. The gonadosomatic index (GSI%) maintained high values from April to July and increased from the II to IV ovarian stages and dropped in the V stage. Levels of plasma, ovary T and E2 and DHP were high from March to July. Plasma T and E2 levels were low in the II stage when most oocytes were previtellogenic, reaching a peak during spawning, and decreased in the V stages when fish were going to late spawning and termination. DHP was detected in all stages of the ovary with a higher level in spawning fish but decreased after spawning. These results revealed that T, E2 and DHP could be involved in ovarian development and DHP may play a significant role as a maturational inducing hormone in blue tang fish.

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