scholarly journals Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Asunción Martín-Ruiz ◽  
Laura Peña ◽  
Alfredo González-Gil ◽  
Lucía Teresa Díez-Córdova ◽  
Sara Cáceres ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Steroid Hormone ◽  
Mice Model ◽  
Hormone Profile

scholarly journals Tumor Growth Progression in Ectopic and Orthotopic Xenografts from Inflammatory Breast Cancer Cell Lines

2021 ◽  
Vol 8 (9) ◽  
pp. 194
Author(s):  
Sara Caceres ◽  
Angela Alonso-Diez ◽  
Belén Crespo ◽  
Laura Peña ◽  
Maria J. Illera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Progression ◽  
Cell Line ◽  
Cancer Cell ◽  
Inflammatory Breast Cancer ◽  
Steroid Hormone ◽  
Cancer Cell Line ◽  
Histological Features ◽  
Inflammatory Breast Cancer Cell ◽  
Orthotopic Xenografts

Xenografts can grow in immunosuppressed hosts, such as SCID mice, and tumor material can be injected into hosts either ectopically or orthotopically. Choosing the correct model to use is a crucial step in animal research. The aim of this study was to report the differences between ectopic and orthotopic xenografts in tumor progression, metastasis capacity, histological features, and steroid hormone profiles in xenografts from the cIMC (canine inflammatory mammary cancer) cell line IPC-366 and hIBC (human inflammatory breast cancer) cell line SUM149. To achieve this purpose, 40 female mice 6–8 weeks old were inoculated with IPC-366 and SUM149 cells subcutaneously (ectopic models) or into mammary fat pad (orthotopic models). Mice were monitored for tumor progression and appearance of metastases, and generated tumors were analyzed in terms of histological examination and steroid hormone production. The results revealed differences in tumor appearance and percentage of metastasis between ectopic and orthotopic models, which were higher in the ectopic xenografts from both cell lines. However, both models had similar characteristics of tumor progression, histological features, and steroid hormone secretion profiles. We show that the ectopic model can be validated as a good and useful model of tumor development in addition to, not contrary to, the orthotopic model in breast cancer research.

scholarly journals Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma

Oncogene ◽  
2019 ◽  
Vol 39 (8) ◽  
pp. 1724-1738 ◽  
Author(s):  
Jing Zhao ◽  
Yiran Hou ◽  
Chun Yin ◽  
Jing Hu ◽  
Tian Gao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Progression ◽  
Cell Cycle Progression ◽  
Critical Role ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Histamine Receptor ◽  
Matrix Metalloproteinase 2 ◽  
Mice Model ◽  
Hcc Cells

AbstractH1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-coupled receptors. Recent studies have shown that H1HR expression is increased in several types of cancer. However, its functional roles in tumor progression remain largely unknown, especially in hepatocellular carcinoma (HCC). We found that H1HR is frequently unregulated in HCC, which is significantly associated with both recurrence-free survival and overall survival in HCC patients. Functional experiments revealed that H1HR promoted both the growth and metastasis of HCC cells by inducing cell cycle progression, formation of lamellipodia, production of matrix metalloproteinase 2, and suppression of cell apoptosis. Activation of cyclic adenosine monophosphate-dependent protein kinase A was found to be involved in H1HR-mediated HCC cell growth and metastasis. In addition, we found that overexpression of H1HR was mainly due to the downregulation of miR-940 in HCC cells. Moreover, the H1HR inhibitor terfenadine significantly suppressed tumor growth and metastasis in an HCC xenograft nude mice model. Our findings demonstrate that H1HR plays a critical role in the growth and metastasis of HCC cells, which provides experimental evidence supporting H1HR as a potential drug target for the treatment of HCC.

Steroid hormone profile of canine inflammatory mammary carcinoma: a preliminary study

2003 ◽  
Vol 84 (2-3) ◽  
pp. 211-216 ◽  
Author(s):  
L Peña ◽  
G Silván ◽  
M.D Pérez-Alenza ◽  
A Nieto ◽  
J.C Illera
Keyword(s):  
Mammary Carcinoma ◽  
Steroid Hormone ◽  
Hormone Profile ◽  
Preliminary Study

Steroid hormone profile in postmenopausal women with ovarian cancer

1994 ◽  
Vol 30 (4) ◽  
pp. 442-445 ◽  
Author(s):  
M.E.R. O'Brien ◽  
M. Dowsett ◽  
I. Fryatt ◽  
E. Wiltshaw
Keyword(s):  
Ovarian Cancer ◽  
Postmenopausal Women ◽  
Steroid Hormone ◽  
Hormone Profile

scholarly journals Hyperactive Neutrophils Infiltrate Vital Organs of Tumor Bearing Host and Contribute to Gradual Systemic Deterioration With Tumor Progression

2021 ◽  
Author(s):  
Kavita Rawat ◽  
Saima Syeda ◽  
Anju Shrivastava
Keyword(s):  
Tumor Progression ◽  
Cancer Progression ◽  
Neutrophil Count ◽  
Mice Model ◽  
Potential Therapeutic Target ◽  
Tumor Bearing ◽  
Systemic Impact ◽  
And Function ◽  
High Infiltration

Various studies have addressed the role of neutrophils in cancer wherein the focus has been drawn on the elevated neutrophil count in blood or at tumor loci. However, cancer has a systemic impact which targets various organs thus challenging the overall physiology of the host. So, it is worthwhile to explore whether and how neutrophils contribute to systemic deterioration in cancer. To discern the systemic role of neutrophils, we monitored their number and function at different stages of tumor growth in Dalton’s lymphoma mice model. Notably, we observed a gradual increase in neutrophil count in blood and their infiltration in vital organs of tumor bearing mice. In parallel, we observed damaged histoarchitecture with significant alterations in biochemical parameters that aggravated with tumor progression. We next examined systemic impact of neutrophil by assessing neutrophil elastase, myeloperoxidase, and matrix metalloproteinases (MMP-8 and MMP-9) wherein we found their upregulated expression and activity in tumor condition. Taken together, our results demonstrate high infiltration and hyperactivation of neutrophils which possibly account for gradual systemic deterioration during cancer progression. Our findings thus implicate neutrophils as a potential therapeutic target that may help to reduce the overall fatality rate of cancer.

HPLC–RIA analysis of steroid hormone profile in a virilizing stromal tumor of the ovary

2004 ◽  
Vol 61 (1-2) ◽  
pp. 47-56 ◽  
Author(s):  
M. Szécsi ◽  
I. Tóth ◽  
J. Gardi ◽  
T. Nyári ◽  
J. Julesz
Keyword(s):  
Steroid Hormone ◽  
Stromal Tumor ◽  
Hormone Profile

scholarly journals Circulating steroid hormone variations throughout different stages of prostate cancer

2017 ◽  
Vol 24 (11) ◽  
pp. R403-R420 ◽  
Author(s):  
Gido Snaterse ◽  
Jenny A Visser ◽  
Wiebke Arlt ◽  
Johannes Hofland
Keyword(s):  
Prostate Cancer ◽  
Tumor Progression ◽  
Steroid Hormones ◽  
Steroid Hormone ◽  
Treatment Resistance ◽  
Detection Methods ◽  
Treatment Modalities ◽  
Adrenal Androgen ◽  
Castration Resistant ◽  
Primary Driver

Steroid hormones play a central role in the maintenance and progression of prostate cancer. The androgen receptor is the primary driver of tumor cell proliferation and is activated by the androgens testosterone and 5α-dihydrotestosterone. Inhibition of this pathway through medical or surgical castration improves survival in the majority of advanced prostate cancer patients. However, conversion of adrenal androgen precursors and alternative steroidogenic pathways have been found to contribute to tumor progression and resistance to treatment. The emergence of highly accurate detection methods allows us to study steroidogenic mechanisms in more detail, even after treatment with potent steroidogenic inhibitors such as the CYP17A1 inhibitor abiraterone. A clear overview of steroid hormone levels in patients throughout the local, metastatic and castration-resistant stages of prostate cancer and treatment modalities is key toward a better understanding of their role in tumor progression and treatment resistance. In this review, we summarize the currently available data on steroid hormones that have been implicated in the various stages of prostate cancer. Additionally, this review addresses the implications of these findings, highlights important studies in this field and identifies current gaps in literature.

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