Inhibition of ferroptosis reduces susceptibility to frequent excessive alcohol consumption-induced atrial fibrillation

Toxicology ◽  
2022 ◽  
Vol 465 ◽  
pp. 153055
Author(s):  
Chang Dai ◽  
Bin Kong ◽  
Tianyou Qin ◽  
Zheng Xiao ◽  
Jin Fang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

scholarly journals Clinical and biochemical aspects of coagulation control in patients with atrial fibrillation and excessive alcohol consumption

2015 ◽  
Vol 96 (5) ◽  
pp. 734-741
Author(s):  
D G Novikov ◽  
A V Indutnyy ◽  
N A Trofimovich ◽  
N I Sidenko ◽  
G A Borzenok ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Alcohol Consumption ◽  
Study Group ◽  
Gamma Glutamyl Transferase ◽  
Excessive Alcohol Consumption ◽  
Gamma Glutamyl ◽  
Target Values ◽  
Excessive Alcohol ◽  
Glutamyl Transferase ◽  
D Dimer

Aim. Reveal the influence of excessive alcohol consumption on blood coagulation system, levels of blood proteins in patients with atrial fibrillation treated with warfarin. Methods. The study included 80 patients with a diagnosis of atrial fibrillation, treated with vitamin K antagonists. The study group included 34 patients with excessive alcohol consumption (according to the questionnaire), the comparison group - 46 patients with no excessive alcohol consumption. Transferrin, hemopexin, aspartate transaminase, alanine transaminase, gamma-glutamyl transferase, carbohydrate-deficient transferrin levels were measured in venous blood serum, serum protein electrophoresis was performed. Parameters of plasma hemostasis tests and D-dimer level were also analyzed. Results. Gamma-glutamyl transferase activity in patients of study group was 1.5 times higher compared to the comparison group (p=0.021). There was no statically significant differences in aspartate transaminase and alanine transaminase activity, but their levels were increased in alcohol abusers with gamma-glutamyl transferase above normal values (55 U/l). None of the patients had increased level of carbohydrate-deficient transferrin. Absolute and relative serum β1-globulin concentrations were significantly reduced in study group patients, while hemopexin and transferrin levels were at the same level as in the control group. No differences of coagulation parameters were between the groups. In the study group, in patients with β1-globulin levels below the median values, international normalized ratio was significantly closer to the target values, but the same patients had higher D-dimer levels, which apparently indicates low effect of anticoagulants. Conclusion. The effect of anticoagulant was low in patients with excessive alcohol consumption and atrial fibrillation, as evidenced by elevated D-dimer levels at international normalized ratio close to the target values. Patients with atrial fibrillation and excessive alcohol consumption with elevated D-dimer levels had serum β1-globulin levels reduced compared to median values.

scholarly journals Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis

Medicines ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 39
Author(s):  
Akihiko Shibamoto ◽  
Tadashi Namisaki ◽  
Junya Suzuki ◽  
Takahiro Kubo ◽  
Satoshi Iwai ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Biological Markers ◽  
Prediction Accuracy ◽  
Total Bilirubin ◽  
Alcoholic Cirrhosis ◽  
Serum Total Bilirubin ◽  
Excessive Alcohol Consumption ◽  
Significant Difference ◽  
Carbohydrate Deficient Transferrin ◽  
Excessive Alcohol

: Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.

scholarly journals Methods for Estimating Avoidable Costs of Excessive Alcohol Consumption

2021 ◽  
Vol 18 (9) ◽  
pp. 4964
Author(s):  
Beata Gavurova ◽  
Miriama Tarhanicova
Keyword(s):  
Czech Republic ◽  
Alcohol Consumption ◽  
Data Availability ◽  
Excessive Alcohol Consumption ◽  
Public Authorities ◽  
The Czech Republic ◽  
Cost Of Disease ◽  
Lost Productivity ◽  
Excessive Alcohol ◽  
The Cost

Background: Alcohol is a risk factor with serious consequences for society and individuals. This study aims to present methods and approaches that might be used to estimate the costs related to excessive alcohol consumption. It emphasizes the need for general methods and approaches that are easily applicable, because the level of digitalization and data availability vary across regions. The lack of data makes many methods inapplicable and useless. The ease of applicability will help to make cost-of-illness studies and their results comparable globally. Methods: This study is based on data from the Czech Republic in 2017. Drinking alcohol results in costs of healthcare, social care, law enforcement, and administrative costs of public authorities. To quantify the cost of drinking in the Czech Republic, the top-down approach, bottom-up approach, human capital approach and attributable fractions were used. Results: In 2017, the cost related to alcohol was estimated at 0.66% of the national GDP. Lost productivity represented 54.45% of total cost related to alcohol. All cost related to alcohol is considered to be avoidable. Conclusions: The methods and approaches applied to estimate the cost of disease or any other health issue should be generalized regarding the availability of data and specifics of provided services to people who are addicted or have any kind of disability.

scholarly journals THE EFFECTIVENESS OF A TAILORED INTERVENTION FOR EXCESSIVE ALCOHOL CONSUMPTION PRIOR TO ELECTIVE SURGERY

2006 ◽  
Vol 41 (6) ◽  
pp. 643-649 ◽  
Author(s):  
SWATI SHOURIE ◽  
KATHERINE M. CONIGRAVE ◽  
ELIZABETH M. PROUDE ◽  
JEANETTE E. WARD ◽  
SONIA E. WUTZKE ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Elective Surgery ◽  
Tailored Intervention ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

scholarly journals Excessive alcohol consumption after liver transplantation impacts on long-term survival, whatever the primary indication

2012 ◽  
Vol 57 (2) ◽  
pp. 306-312 ◽  
Author(s):  
Stéphanie Faure ◽  
Astrid Herrero ◽  
Boris Jung ◽  
Yohan Duny ◽  
Jean-Pierre Daures ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Alcohol Consumption ◽  
Excessive Alcohol Consumption ◽  
Term Survival ◽  
Long Term Survival ◽  
Primary Indication ◽  
Excessive Alcohol

scholarly journals Protective Effects of Dioscorea batatas Flesh and Peel Extracts against Ethanol-Induced Gastric Ulcer in Mice

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1680 ◽  
Author(s):  
Siyul Byeon ◽  
Jisun Oh ◽  
Ji Lim ◽  
Jeong Lee ◽  
Jong-Sang Kim
Keyword(s):  
Gastric Ulcer ◽  
Alcohol Consumption ◽  
Plasma Levels ◽  
Gastric Mucosal Damage ◽  
Heme Oxygenase 1 ◽  
Excessive Alcohol Consumption ◽  
Oral Supplementation ◽  
Ethanolic Extracts ◽  
Excessive Alcohol ◽  
Dioscorea Batatas

Gastric ulcer is a major digestive disorder and provoked by multifactorial etiologies, including excessive alcohol consumption. In this study, we examined the gastroprotective effect of aqueous and ethanolic extracts of Dioscorea batatas Decne (DBD; commonly called Chinese yam) flesh or peel against acidified ethanol-induced acute gastric damage in mice. Our findings demonstrated that oral supplementation of aqueous or ethanolic extracts of DBD flesh or peel before ulcer induction was significantly effective in macroscopically and histologically alleviating ethanol-induced pathological lesions in gastric mucosa, decreasing the plasma levels of inflammatory mediators, such as nitric oxide and interleukin-6, attenuating the gastric expression of cyclooxygenase-2, and increasing the gastric content of prostaglandin E2. In particular, pretreatment with the flesh extract prepared in 60% ethanol prominently decreased the expression of biomarkers of oxidative stress, including the plasma levels of 8-hydroxy-2-guanosine and malondialdehyde, and restored heme oxygenase-1 expression and superoxide dismutase activity in the stomach. Overall, these findings suggest that the oral supplementation with DBD extract, especially flesh ethanol extract, prior to excessive alcohol consumption, may exert a protective effect against ethanol-induced gastric mucosal damage in vivo, presumably through the activation of the antioxidant system and suppression of the inflammatory response.

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