Identification and characterization of the cell surface targets of the snake venom myotoxin, crotamine, that mediates its anti-proliferative activity in cancer cells

Toxicon ◽  
2018 ◽  
Vol 150 ◽  
pp. 324
Author(s):  
C. Yin ◽  
E.E. Sanchez ◽  
M. Moczygemba ◽  
P. Davies
2014 ◽  
Vol 13 (1) ◽  
pp. 190 ◽  
Author(s):  
Liliana P Cantini ◽  
Lourdes M Andino ◽  
Christopher C Attaway ◽  
Betsy Butler ◽  
Anca Dumitriu ◽  
...  

2001 ◽  
Vol 276 (44) ◽  
pp. 40417-40423 ◽  
Author(s):  
Xin Wang ◽  
Shuyuan Yeh ◽  
Guan Wu ◽  
Cheng-Lung Hsu ◽  
Liang Wang ◽  
...  

2006 ◽  
Vol 20 (4) ◽  
pp. E27 ◽  
Author(s):  
Patrizia Tunici ◽  
Dwain Irvin ◽  
Gentao Liu ◽  
Xiangpeng Yuan ◽  
Zeng Zhaohui ◽  
...  

✓ The observation of similarities between the self-renewal mechanisms of stem cells and cancer cells has led to the new concept of the cancer stem cell. In cases of leukemia, multiple myeloma, and breast cancer, cells with a high self-renewal potential have been identified. Furthermore, investigators have shown these cells' ability to drive the formation and growth of the tumor. Brain tumors have also been reported to possess a subpopulation of cancer stemlike cells that have the ability to proliferate, self-renew, and be multipotent. When grafted into mice, these cells are also able to generate a tumor that recapitulates that of the patient from whom the cells were derived. The identification and characterization of this new category of cells call for new therapies capable of selectively targeting and killing these multifaceted cells.


1988 ◽  
Vol 28 (5) ◽  
pp. 295-302 ◽  
Author(s):  
Clare M. Baecher ◽  
Anthony J. Infante ◽  
Karen L. Semcheski ◽  
John G. Frelinger

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