scholarly journals Brain tumor stem cells: new targets for clinical treatments?

2006 ◽  
Vol 20 (4) ◽  
pp. E27 ◽  
Author(s):  
Patrizia Tunici ◽  
Dwain Irvin ◽  
Gentao Liu ◽  
Xiangpeng Yuan ◽  
Zeng Zhaohui ◽  
...  

✓ The observation of similarities between the self-renewal mechanisms of stem cells and cancer cells has led to the new concept of the cancer stem cell. In cases of leukemia, multiple myeloma, and breast cancer, cells with a high self-renewal potential have been identified. Furthermore, investigators have shown these cells' ability to drive the formation and growth of the tumor. Brain tumors have also been reported to possess a subpopulation of cancer stemlike cells that have the ability to proliferate, self-renew, and be multipotent. When grafted into mice, these cells are also able to generate a tumor that recapitulates that of the patient from whom the cells were derived. The identification and characterization of this new category of cells call for new therapies capable of selectively targeting and killing these multifaceted cells.

2015 ◽  
Vol 3 (2) ◽  
pp. 177-183
Author(s):  
L. Belska ◽  
M. Lisyany

The review presents the current conceptions of the origin, methods of isolation and phenotypic characterization of the brain tumor stem cells. Phenotypic similarity in molecular markers between cancer and neural stem cells is shown. Therapeutic approaches of impact on the brain tumor stem cells and on the intracellular signaling pathways of cancer stem cells are described.


Oncotarget ◽  
2015 ◽  
Vol 6 (33) ◽  
pp. 34475-34493 ◽  
Author(s):  
Andreas Ritter ◽  
Alexandra Friemel ◽  
Friderike Fornoff ◽  
Mouhib Adjan ◽  
Christine Solbach ◽  
...  

2014 ◽  
Author(s):  
Jennifer Dine ◽  
Sireesha Garimella ◽  
Kristie Gehlhaus ◽  
Magda Grandin ◽  
Natasha Caplen ◽  
...  

2011 ◽  
Vol 102 (7) ◽  
pp. 1350-1357 ◽  
Author(s):  
Manoranjan Santra ◽  
Sutapa Santra ◽  
Ben Buller ◽  
Kastuv Santra ◽  
Ankita Nallani ◽  
...  

2014 ◽  
Vol 15 (2) ◽  
pp. 185-198 ◽  
Author(s):  
Zhe Zhu ◽  
Muhammad Amir Khan ◽  
Markus Weiler ◽  
Jonas Blaes ◽  
Leonie Jestaedt ◽  
...  

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