Conversion to Mycophenolate Mofetil From Azathioprine Shows Significant Positive Effect on Graft Function in Long-Term Past–Kidney Transplantation Stable-State Patients

2014 ◽  
Vol 46 (2) ◽  
pp. 411-414 ◽  
Author(s):  
S. Nakazawa ◽  
H. Kishikawa ◽  
M. Kawamura ◽  
N. Ueda ◽  
T. Hirai ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplantation ◽  
Graft Function ◽  
Stable State ◽  
Significant Positive Effect ◽  
Positive Effect

scholarly journals Successful rescue therapy with mycophenolate mofetil in kidney transplantation improves the long-term graft survival

Medicina ◽  
2007 ◽  
Vol 43 (12) ◽  
pp. 953 ◽  
Author(s):  
Jaanus Kahu ◽  
Aleksander Lõhmus ◽  
Madis Ilmoja ◽  
Ülle Kirsimägi ◽  
Gennadi Timberg ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplantation ◽  
Graft Survival ◽  
Cyclosporine A ◽  
Negative Impact ◽  
Rescue Therapy ◽  
Graft Loss ◽  
Graft Function ◽  
Significant Difference

Objective. The aim of this study was to compare the graft survival after kidney transplantation in patients treated with azathioprine (AZA) or mycophenolate mofetil (MMF) and analyze the significance of different risk factors for graft survival. Material and methods. A total of 137 patients, transplanted between January 1996 and June 2001, were retrospectively divided into two groups: patients who received AZA together with cyclosporine A and methylprednisolone (AZA group, n=72) and patients who received MMF either immediately or were switched from AZA to MMF during 3 months (MMF group, n=65). Results. According to Kaplan-Meier analysis, a 1-year graft survival was 79% in the AZA group and 85% in the MMF group; a 6-year graft survival was 51% and 67%, respectively (P=0.046). Multivariate Cox survival model demonstrated that MMF therapy reduced the risk of graft loss by 34% (P=0.028), while delayed graft function increased the risk of graft loss (risk ratio 2.26, P=0.009). A statistically significant difference in total cholesterol level (6.7 vs. 5.7 mmol/L, respectively; P=0.002), mean systolic blood pressure (145 vs. 134 mmHg, P=0.009), and cyclosporine A daily dose (238 vs. 203 mg, P=0.015) between the AZA and MMF groups at 1 year was revealed. Conclusion. MMF rescue therapy improves the long-term graft survival compared to AZA despite high early rejection rate and avoids the negative impact of acute rejections on graft survival.

scholarly journals The Endothelial Glycocalyx as a Target of Ischemia and Reperfusion Injury in Kidney Transplantation—Where Have We Gone So Far?

2021 ◽  
Vol 22 (4) ◽  
pp. 2157
Author(s):  
Anila Duni ◽  
Vassilios Liakopoulos ◽  
Vasileios Koutlas ◽  
Charalampos Pappas ◽  
Michalis Mitsis ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Reperfusion Injury ◽  
Heparan Sulphate ◽  
Graft Function ◽  
Endothelial Permeability ◽  
Endothelial Glycocalyx ◽  
Ischemia And Reperfusion Injury ◽  
New Era ◽  
Sphingosine 1 Phosphate

The damage of the endothelial glycocalyx as a consequence of ischemia and/or reperfusion injury (IRI) following kidney transplantation has come at the spotlight of research due to potential associations with delayed graft function, acute rejection as well as long-term allograft dysfunction. The disintegration of the endothelial glycocalyx induced by IRI is the crucial event which exposes the denuded endothelial cells to further inflammatory and oxidative damage. The aim of our review is to present the currently available data regarding complex links between shedding of the glycocalyx components, like syndecan-1, hyaluronan, heparan sulphate, and CD44 with the activation of intricate immune system responses, including toll-like receptors, cytokines and pro-inflammatory transcription factors. Evidence on modes of protection of the endothelial glycocalyx and subsequently maintenance of endothelial permeability as well as novel nephroprotective molecules such as sphingosine-1 phosphate (S1P), are also depicted. Although advances in technology are making the visualization and the analysis of the endothelial glycocalyx possible, currently available evidence is mostly experimental. Ongoing progress in understanding the complex impact of IRI on the endothelial glycocalyx, opens up a new era of research in the field of organ transplantation and clinical studies are of utmost importance for the future.

LONG-TERM KIDNEY GRAFT FUNCTION AFTER COMBINED LIVER-KIDNEY TRANSPLANTATION

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 696
Author(s):  
R Ruiz ◽  
B Fischbach ◽  
N Onaca ◽  
G McKenna ◽  
H Randall ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Function ◽  
Kidney Graft

The Impact of Mycophenolate Mofetil on Long-Term Outcomes in Kidney Transplantation

2005 ◽  
Vol 80 (Supplement) ◽  
pp. S211-S220 ◽  
Author(s):  
Titte R. Srinivas ◽  
Bruce Kaplan ◽  
Jesse D. Schold ◽  
Herwig-Ulf Meier-Kriesche
Keyword(s):  
Mycophenolate Mofetil ◽  
Kidney Transplantation ◽  
Long Term Outcomes ◽  
The Impact

scholarly journals The Factors Affecting Islamic Financing for Homeownership

2021 ◽  
pp. 48-54
Author(s):  
Neva Sunba Dena ◽  
◽  
Suhel Suhel ◽  
Imam Asngari ◽  
◽  
...  
Keyword(s):  
Household Income ◽  
Negative Impact ◽  
Least Square ◽  
Islamic Banks ◽  
Significant Positive Effect ◽  
Short Term ◽  
Ordinary Least Square ◽  
Study Results ◽  
Positive Effect

Indonesia has a significant and growing shortfall of housing. Existing supply is in poor condition and demand is rising for new units. Meanwhile, people's purchasing power to buy a house is still relatively low. Government overcomes added stock housing availability by collaborating with private developers to help meet the demand for housing needs. Islamic banks can provide funds to buy houses for the community. This study analyzes the effect of third-party fund (TPF), margin of homeownership financing (PPR), inflation, and household income on Islamic financing for homeownership. The analytical model used in this research is the ordinary least square with the Error Correction Model (ECM) method. The Ordinary Least Square (OLS) method in this study is used to see the relationship between the short-term and long-term effects of the independent variables on the dependent variable. The analytical tool used in this research is Econometric Views (EViews 10 Standard Edition for Windows). The study results show that in the short term, the TPF, PPR margin, inflation, and household income variables have a significant positive effect on homeownership financing in Islamic banks in Indonesia. The long term TPF, inflation, and household income variables have a significant positive effect on homeownership financing in Islamic banks in Indonesia, but the variable of PPR margin has a significant negative impact on sharia financing for homeownership.

scholarly journals ANALISIS PENGARUH GONCANGAN FAKTOR EKSTERNAL TERHADAP PERTUMBUHAN EKONOMI

2017 ◽  
Vol 6 (1) ◽  
pp. 25
Author(s):  
Monica Wulandari ◽  
Hasdi Aimon ◽  
Mike Triani
Keyword(s):  
Economic Growth ◽  
Exchange Rate ◽  
Error Correction ◽  
Error Correction Model ◽  
External Factors ◽  
Least Square ◽  
Significant Positive Effect ◽  
Correction Model ◽  
Positive Effect

The purpose of this research is to see how far the influence of external factors toward the economic growth in Indonesia and also to see any external factors that can decreasing economic growth in short and long term. The method is used in this research is Ordinary Least Square with use Error Correction Model (ECM) test and Cointegration. Based on analysis data was obtained three conclusions were; The first is based on the results of multiple regression, foreign investment and world oil prices and a significant positive effect on economic growth in Indonesia, while the exchange rate and foreign debt and no significant positive effect on economic growth in Indonesia at the 5% significance level. The second is in the short term through the Error Correction Model (ECM) test, the world oil price and foreign direct investment to boost economic growth while exchange rate USD / $ (NTR) and External Debt (ED) can shocks the economic growth in Indonesia. The third is in the long term through cointegration test, the variables included in the model and no significant negative effect on economic growth

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