Tuberculin skin test conversion among health sciences students: A retrospective cohort study

Abstract Background: Tuberculin skin test (TST) has been the most commonly used test for diagnosis of tuberculosis (TB) infection in China for many years, because of well-established algorithms for test interpretation and a good cost-effectiveness. To our knowledge , there is no report or guideline on the influence of varicella vaccine on the sensitivity of TST in China. This paper aims to explore the effect of live attenuated varicella vaccine on the sensitivity of TST.Methods: A retrospective cohort study was carried out in a high school in Wuxi, Jiangsu province in 2020. TST and emergency varicella vaccine were administered to students in grade one of the high school which had both TB and varicella cases. The mean diameter of induration of TST were compared between 73d before varicella vaccine, 9d and 120d after varicella vaccine respectively. The retrospective cohort study was used to analyze the effect of live attenuated varicella vaccine on TST.Results: There were 45 students in the class of the high school had three TST, and 22 of them were vaccinated varicella. After 9 days of varicella vaccination, the mean diameter of induration was significantly smaller than that before the vaccination of 73 days and after the vaccination of 120 days (p<0.05), respectively. Moreover, there is no significant different for mean diameter of induration between the TST before the vaccination of 73 days and after the vaccination of 120 days (p=0.551). The retrospective cohort study analysis indicated that 9 days after varicella vaccination ( RR, 6.071, 95%CI, 1.667～22.116, P=0.007 ) was associated with the changed mean induration diameter of TST. After vaccination of 120 days ( RR, 3.474, 95%CI, 0.333～36.240, P=0.346 ) was not associated with the changed mean induration of TST.Conclusions: Live attenuated varicella vaccine may temporarily affect the sensitivity of tuberculin skin test.

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Assessing the Impact of Isoniazid Preventive Therapy (IPT) on Tuberculosis Incidence and Predictors of Tuberculosis among Adult Patients Enrolled on ART in Nekemte Town, Western Ethiopia: A Retrospective Cohort Study

Interdisciplinary Perspectives on Infectious Diseases ◽

10.1155/2019/1413427 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Gemechu Tiruneh ◽

Alemayehu Getahun ◽

Emiru Adeba

Keyword(s):

Cohort Study ◽

Tuberculin Skin Test ◽

Skin Test ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Preventive Therapy ◽

Isoniazid Preventive Therapy ◽

Clinical Staging ◽

Tuberculosis Incidence ◽

Western Ethiopia

Background. Isoniazid preventive therapy is a prophylactic treatment used in the prevention of active tuberculosis. It is known to be most effective in preventing tuberculosis in patients with positive tuberculin skin test. Methods. A retrospective cohort study centering on two institutions in Nekemte town, Western Ethiopia, was employed. Secondary data of 600 medical records were analyzed by Cox regression. Result. Tuberculosis incidence among the Isoniazid treated group was 1.98 per 100 person-years and 4.52 per 100 person-years in the untreated group. CD4 cell count, clinical staging, body mass index (BMI), not using cotrimoxazole, body weight, and functional status were significant predictors of tuberculosis risk. Isoniazid preventive therapy use was associated with 55% reduction of tuberculosis incidence. Conclusion. Isoniazid preventive therapy use was associated with significant reduction in tuberculosis incidence, even in the absence of Tuberculin Skin Test (TST). Therefore, isoniazid preventive therapy (IPT) coverage should be used more widely, with special emphasis given to patients at higher risk of tuberculosis. The study shows that the absence of TST testing should not be a limitation.

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Risk for Tuberculosis Disease Among Contacts with Prior Positive Tuberculin Skin Test: A retrospective Cohort Study, New York City

Journal of General Internal Medicine ◽

10.1007/s11606-015-3180-2 ◽

2015 ◽

Vol 30 (6) ◽

pp. 742-748 ◽

Cited By ~ 1

Author(s):

Prabhu P. Gounder ◽

Tiffany G. Harris ◽

Holly Anger ◽

Lisa Trieu ◽

Jeanne Sullivan Meissner ◽

...

Keyword(s):

New York ◽

New York City ◽

Cohort Study ◽

Tuberculin Skin Test ◽

Skin Test ◽

Retrospective Cohort Study ◽

York City ◽

Retrospective Cohort ◽

Positive Tuberculin Skin Test ◽

Tuberculosis Disease

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The association between tuberculin skin test result and active tuberculosis risk of college students in Beijing, China: a retrospective cohort study

BMC Infectious Diseases ◽

10.1186/s12879-019-4238-2 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 6

Author(s):

Demin Cao ◽

Zhiguo Zhang ◽

Zhen Yang ◽

Shubo Ma ◽

Zhaogang Sun ◽

...

Keyword(s):

College Students ◽

Cohort Study ◽

Tuberculin Skin Test ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Active Tuberculosis ◽

Beijing China ◽

Skin Test Result ◽

Test Result ◽

Tuberculosis Risk

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Tuberculin skin test conversion and primary progressive tuberculosis disease in the first 5 years of life: a birth cohort study from Cape Town, South Africa

The Lancet Child & Adolescent Health ◽

10.1016/s2352-4642(17)30149-9 ◽

2018 ◽

Vol 2 (1) ◽

pp. 46-55 ◽

Cited By ~ 12

Author(s):

Leonardo Martinez ◽

David M le Roux ◽

Whitney Barnett ◽

Attie Stadler ◽

Mark P Nicol ◽

...

Keyword(s):

South Africa ◽

Cohort Study ◽

Tuberculin Skin Test ◽

Birth Cohort ◽

Skin Test ◽

Cape Town ◽

Birth Cohort Study ◽

Primary Progressive ◽

Tuberculin Skin Test Conversion ◽

Tuberculosis Disease

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Validation of billing code combinations to identify cardiovascular magnetic resonance imaging scans in Ontario, Canada: a retrospective cohort study

BMJ Open ◽

10.1136/bmjopen-2017-021370 ◽

2018 ◽

Vol 8 (10) ◽

pp. e021370

Author(s):

Idan Roifman ◽

Feng Qiu ◽

Kim A Connelly ◽

Graham A Wright ◽

Michael Farkouh ◽

...

Keyword(s):

Cohort Study ◽

Cardiovascular Magnetic Resonance ◽

Magnetic Resonance ◽

Positive Predictive Value ◽

Retrospective Cohort Study ◽

Predictive Value ◽

Gold Standard ◽

Retrospective Cohort ◽

Health Sciences ◽

Billing Code

ObjectivesCardiovascular magnetic resonance (CMR) imaging is the gold-standard test for the assessment of heart function. Despite its importance, many jurisdictions lack specific billing codes that can be used to identify patient receipt of CMR in administrative databases, limiting the ability to perform ‘big data’ CMR studies. Our objective was to identify the optimal billing code combination to identify patients who underwent CMR using administrative data in Ontario.DesignRetrospective cohort study.SettingQuaternary care academic referral centre in Ontario, Canada.ParticipantsWe tested all billing code combinations in order to identify the optimal one to determine receipt of CMR. The reference gold standard was a list of all cardiothoracic magnetic resonance scans performed at Sunnybrook Health Sciences Centre between 1 January 2014 and 31 December 2016, verified by chart audit. We assessed the diagnostic performance (accuracy, sensitivity, specificity, positive predictive value and negative predictive value) for all code combinations.ResultsOur gold-standard cohort consisted of 2339 thoracic MRIs that were performed at Sunnybrook Health Sciences Centre from 1 January 2014 to 31 December 2016. Of these, 2139 (91.5%) were CMRs and 200 (8.5%) were chest MRIs. We identified the most accurate billing combination for the determination of patient receipt of CMR. This combination resulted in an accuracy of 95.3% (95% CI 94.4% to 96.2%), sensitivity of 97.4% (95% CI 96.6% to 98.1%), specificity of 86.4% (95% CI 83.1% to 89.6%), positive predictive value of 96.9% (95% CI 96.1% to 97.6%) and negative predictive value of 88.4% (95% CI 85.4% to 91.5%).ConclusionsOur study is the first to verify the ability to accurately identify patient receipt of CMR using administrative data, facilitating more robust population-based CMR studies in the future.

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