Non-enhanced Pattern on Contrast-Enhanced Ultrasound in the Local Efficacy Assessment of Irreversible Electroporation Ablation of Pancreatic Adenocarcinoma

2018 ◽  
Vol 44 (9) ◽  
pp. 1986-1995
Author(s):  
Manxia Lin ◽  
Xiaoyan Xie ◽  
Ming Xu ◽  
Shiting Feng ◽  
Wenshuo Tian ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Irreversible Electroporation ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Efficacy Assessment

scholarly journals Irreversible Electroporation in Patients With Liver Tumours: Treated-area Patterns With Contrast-enhanced Ultrasound

2020 ◽  
Author(s):  
Linyu Zhou ◽  
Shanyu Yin ◽  
Weilu Chai ◽  
Qiyu Zhao ◽  
Guo Tian ◽  
...  
Keyword(s):  
Irreversible Electroporation ◽  
Hepatic Metastases ◽  
Percutaneous Ablation ◽  
Contrast Enhanced Ultrasound ◽  
Liver Tumours ◽  
Gold Standard Method ◽  
Contrast Enhanced ◽  
Conventional Ultrasound ◽  
Malignant Liver ◽  
A Prospective Study

Abstract Background: To describe the contrast-enhanced ultrasound imaging findings of liver tumours after percutaneous ablation by irreversible electroporation (IRE). Methods: A prospective study of 21 malignant liver tumours (19 primary hepatic tumours and 2 hepatic metastases) treated by IRE ablation was performed. The ablation zones were evaluated by two examiners in a consensus reading performed immediately, 1 day, and 1 month after IRE ablation. The gold standard method with which the effectiveness of the treatment at 1 month is compared, is MRI. Results: Immediately after IRE ablation and up to 1 month later, the ablation zones gradually changed from hypo-echogenicity to hyper-echogenicity on conventional ultrasound, and becomes non-enhancement on contrast-enhanced ultrasound (CEUS). There was substantial agreement (κ = 0.77, p < 0.05) between the results obtained with CEUS and those obtained with MRI 1 month after IRE ablation. Conclusions: We conclude that CEUS could be an effective tool for assessing post-irreversible electroporation ablation changes after 1 month. CEUS enables the depiction of tumour vascularity in real time and provides an easy, repeatable way.

scholarly journals Irreversible electroporation in patients with liver tumours: treated-area patterns with contrast-enhanced ultrasound

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Linyu Zhou ◽  
Shanyu Yin ◽  
Weilu Chai ◽  
Qiyu Zhao ◽  
Guo Tian ◽  
...  
Keyword(s):  
Irreversible Electroporation ◽  
Tumour Response ◽  
Percutaneous Ablation ◽  
Ablation Zone ◽  
Contrast Enhanced Ultrasound ◽  
Liver Tumours ◽  
Gold Standard Method ◽  
Contrast Enhanced ◽  
Malignant Liver ◽  
A Prospective Study

Abstract Background Familiarity with post-IRE imaging interpretation is of considerable importance in determining ablation success and detecting recurrence. CEUS can be used to assess the tumour response and characteristics of the ablation zone. It is of clinical interest to describe the ultrasonographic findings of liver tumours after irreversible electroporation (IRE) percutaneous ablation. Methods A prospective study of 24 cases of malignant liver tumours (22 cases of primary liver tumours and 2 cases of liver metastases) treated by IRE ablation was conducted. Two inspectors evaluated the ablation zone in a consensus reading performed immediately, 1 day, and 1 month after IRE ablation. The gold standard method, magnetic resonance imaging (MRI), was used to evaluate the effectiveness of the treatment at 1 month. Results Immediately after IRE ablation and up to 1 month later, the ablation zones gradually changed from hypo-echogenicity to hyper-echogenicity on conventional ultrasound and showed non-enhancement on contrast-enhanced ultrasound (CEUS). One month after IRE ablation, CEUS and MRI results were highly consistent (κ = 0.78, p < 0.05). Conclusions We conclude that CEUS may be an effective tool for assessing post-IRE ablation changes after 1 month. CEUS enables the depiction of tumour vascularity in real time and serves as an easy, repeatable method.

Contrast enhanced ultrasound (CEUS) with parametric imaging after irreversible electroporation (IRE) of the prostate to assess the success of prostate cancer treatment

2020 ◽  
pp. 1-8
Author(s):  
Ernst Michael Jung ◽  
Martin Engel ◽  
Philipp Wiggermann ◽  
Andreas Schicho ◽  
Markus Lerchbaumer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Local Recurrence ◽  
Predictive Value ◽  
Irreversible Electroporation ◽  
Residual Tumor ◽  
Parametric Imaging ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Tumor Material ◽  
Transabdominal Sonography

AIM: The aim of this study was to assess the success of irreversible electroporation (IRE) in prostate cancer and to differentiate between reactive changes and tumor. MATERIAL AND METHODS: This is a retrospective pilot study of 50 patients after irreversible electroporation (IRE) in prostate cancer between 50–79 years (mean age 65 years). Each patient received a transabdominal sonography using a 1–6 MHz convex matrix probe. Contrast-enhanced ultrasound (CEUS) was performed after i.v. bolus injection of 2.0 ml sulphur hexafluoride microbubbles. DICOM loops were continuously stored up to one minute. Parametric images were calculated by integrated perfusion analysis software. A comparison was drawn to a follow-up MRI six months after ablation. RESULTS: While 13 patients showed local recurrence, 37 patients were successfully treated, meaning no local recurrence within six months after ablation. 18 patients showed signs of prostatitis after IRE. Tumorous changes were visually characterized by dynamic early nodular hypervascularization with fast and high wash-in. Correspondingly, nodular red and yellow shades were seen in parametric imaging. All patients with remaining tumor were correctly identified with CEUS and parametric imaging. After IRE there is a relevant decrease in tumor microcirculation in all patients, as seen in more purple shades of the prostate. The sensitivity for detecting residual tumor with CEUS compared to MRI was 76 %, the specificity was 81 %. The corresponding positive predictive value (PPV) was 73 % and the negative predictive value (NPV) was 83 %. CONCLUSION: CEUS and parametric imaging enable a critical analysis of post-ablation defects after IRE for prostate cancer even with a transabdominal approach. Remaining tumor can be detected with the help of pseudo-colors.

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