TGFBI-promoted Adhesion, Migration and Invasion of Human Renal Cell Carcinoma Depends on Inactivation of von Hippel-Lindau Tumor Suppressor

Urology ◽  
2012 ◽  
Vol 79 (4) ◽  
pp. 966.e1-966.e7 ◽  
Author(s):  
Donghao Shang ◽  
Yuting Liu ◽  
Peiqian Yang ◽  
Yongqian Chen ◽  
Ye Tian
2007 ◽  
Vol 67 (12) ◽  
pp. 5896-5905 ◽  
Author(s):  
Patrick D. Sutphin ◽  
Denise A. Chan ◽  
James M. Li ◽  
Sandra Turcotte ◽  
Adam J. Krieg ◽  
...  

2002 ◽  
Vol 167 (2 Part 1) ◽  
pp. 713-717 ◽  
Author(s):  
KIMINARI HAMANO ◽  
MARIKO ESUMI ◽  
HIROSHI IGARASHI ◽  
KENJI CHINO ◽  
JUN′ICHI MOCHIDA ◽  
...  

Open Medicine ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 226-230 ◽  
Author(s):  
Wu Xiao-fen ◽  
Chen Ting ◽  
Li Jie ◽  
Ma Deng-yang ◽  
Zhu Qing-feng ◽  
...  

AbstractObjectiveThe aim of this study was to investigate the correlation of von Hippel-Lindau tumor suppressor (VHL) mRNA expression and jade family PHD finger 1 (Jade-1) gene expression in patients with renal cell carcinoma (RCC). Another aim of this study was to analyze the relationship of these two genes with clinicalpathological features of the RCC patients. Methods: A total of 75 RCC patients who received surgically therapy in our hospital were included. All patients had complete pathological data. The expression of VHL/Jade-1 was determined by real-time polymerase chain reaction (RT-PCR). Results: VHL and Jade-1 were both obviously downregulated in RCC tissues than that of the matched normal tissues, and both negatively correlated with tumor size as well as tumor grade. And we found a fine association of VHL gene expression with Jade-1. Conclusion: VHL/Jade-1 exhibited significantly decreased expression in RCC tissues and was closely related to the clinical prognosis of patients. The finding of VHL expression positively correlated with Jade-1 expression shed light and provided crucial evidence on the connection of VHL protein with Wnt/b-catenin pathway.


2010 ◽  
Vol 56 (3) ◽  
pp. 395-406
Author(s):  
Instituto Nacional de Câncer José de Alencar Gomes da Silva

Resumos escolhidos para publicação. Nessa edição, os títulos foram: Extramitochondrial Fumarate Inhibits Multiple 2-OG Oxygenases in Fumarate Hydratase Deficient Cells; What is the Best Treatment for Renal Lesions in VHL?; Characterization of the VHL-ECM Pathway; Induction of Extreme Metabolic Depression by the Nucleolus; Mutation of SDHB and Inherited RCC Susceptibility; Metabolic Links to Renal Cancer; Radiosurgery for Cerebellar Hemangioblastomas; Neoplastic Diagnosis Timing Profile in von Hippel-Lindau´s Patients in a Personal Series; Regulation of the VHL Tumor Suppressor; Destructive Targeting via VHL Beyond HIF; Folliculin Functional Studies and Mouse Models of Birt-Hogg-Dube’ Syndrome; A Zebrafish Model for VHL; Relief of Intractable Nausea after Resection of Brainstem Hemangioblastoma in Patients with von Hippel-Lindau Disease: a Clinical Series; Somatic Alteration of the VHL Gene in Sporadic Renal-Cell Carcinomas as a Potential Biomarker; VHL Tumor Suppressor Protein Regulates Oncogenic Macroautophagy in Renal Clear Cell Carcinoma (RCC); Identification of Germline Mutations in the VHL Gene of Families with the von Hippel-Lindau Disease; Expression Profile in von Hippel-Lindau Disease Associated and Sporadic Clear-Cell Renal Cell Carcinomas; Proposed Changes to the VHL Handbook; Evaluation of the Somatic Alterations of the VHL Gene in Renal Cell Carcinoma Associated with von Hippel-Lindau Disease (VHL); Copy Number Variation Analysis of a Pancreatic Neuroendocrine Tumor (NET) from a Patient with von Hippel-Lindau (VHL); Molecular Dynamics Study of the Mutant pVHL Phe76del and its Interactions with Components of the pVHL Complex; Genomic Copy Number Variation Analysis in VHL-Associated Renal Cell Carcinomas Suggests Clonality; Management of Brainstem and Spinal cord Hemangioblastomas in Patients with von Hippel-Lindau Disease; The Benefits of Ultrasound in Resection of CNS Hemangioblastomas; Management of Central Nervous System Hemangioblastomas in von Hippel-Lindau Disease; Neuronal Differentiation of Stem cells by Transfer of a VHL Peptide and Regenerative Therapy; Endolymphatic Sac Tumors (ELST) in VHL Patients - Evaluation of Screening Methods in a National Study; Delineating Genotype-Phenotype Correlations Among Brazilian Families with von Hippel-Lindau Disease; Endothelial Fenestrations Associated with VHL Gene Alteration is a Potent Target of Anti-VEGF Therap; Role of Pregnancy on Hemangioblastomas in von Hippel-Lindau Disease: a Retrospective French Study; An Evaluation of the Danish National Clinical Guidelines for Von Hippel-Lindau (VHL); Vitreoretinal Surgery for Severe Retinal Capillary Hemangiomas; Oncololytic Targeting of Renal Cell Carcinoma via Encephalomyocarditis Virus; Emerging Therapeutic Options for VHL Patients: a Tale of three Studies; Altering the Stability of Mutant VHL: Potential Therapeutic Consequences; Tale of the Tail: Clinical and Functional Properties of Novel VHL Mutation (X214L) Consistent with Type 2A Phenotype and Low Risk of Renal Cell Carcinoma; Knife for Intracranial Hemangioblastomas in von Hippel-Lindau Patients. When and How?; VHL in Brazil: Genetics, Biobanking and VHL Family Care; Understanding VHL Disease: Molecular Characterization of a Spanish Series; Case Report: Radiosurgery for Endolymphatic Sac Tumor in a Patient with von Hippel-Lindau Disease; Primary Cilium: a Tumor Suppressor Organelle.


2001 ◽  
pp. 1088-1092 ◽  
Author(s):  
BRIAN GRADY ◽  
REZA GOHARDERAKHSHAN ◽  
JAMES CHANG ◽  
LEOPOLDO ALVES RIBEIRO-FILHO ◽  
GEETHA PERINCHERY ◽  
...  

2001 ◽  
Vol 166 (3) ◽  
pp. 1088-1092 ◽  
Author(s):  
BRIAN GRADY ◽  
REZA GOHARDERAKHSHAN ◽  
JAMES CHANG ◽  
LEOPOLDO ALVES RIBEIRO-FILHO ◽  
GEETHA PERINCHERY ◽  
...  

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