Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves

AbstractCryptosporidium parvumis an important zoonotic protozoan pathogen that causes acute infection and self-limiting gastrointestinal disease in neonatal calves. There are currently no consistently effective antimicrobials available to control cryptosporidiosis. Therefore, immunotherapeutic and vaccination protocols offer the greatest potential for long-term control of the disease. In order to devise effective control measures, it is important to better define mucosal immunity toC. parvumin young calves. This review summarizes the information that has accumulated over the last decade which helps to define the intestinal mucosal immune system in neonatal calves, and the events that occur in the intestinal mucosa after infection byC. parvum.

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Recombinant bovine interleukin-12 stimulates a gut immune response but does not provide resistance to Cryptosporidium parvum infection in neonatal calves

Veterinary Parasitology ◽

10.1016/j.vetpar.2005.05.062 ◽

2006 ◽

Vol 135 (3-4) ◽

pp. 259-268 ◽

Cited By ~ 7

Author(s):

Paolo Pasquali ◽

Ronald Fayer ◽

Dante Zarlenga ◽

Ana Canals ◽

Tine de Marez ◽

...

Keyword(s):

Immune Response ◽

Cryptosporidium Parvum ◽

Interleukin 12 ◽

Neonatal Calves

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Report of fatal mixed infection with Cryptosporidium parvum and Giardia intestinalis in neonatal calves

Acta Parasitologica ◽

10.1515/ap-2017-0026 ◽

2017 ◽

Vol 62 (1) ◽

Cited By ~ 6

Author(s):

Yuu Matsuura ◽

Makoto Matsubayashi ◽

Satoko Nukata ◽

Tomoyuki Shibahara ◽

Osamu Ayukawa ◽

...

Keyword(s):

Dairy Cattle ◽

Cryptosporidium Parvum ◽

Mixed Infection ◽

Giardia Intestinalis ◽

Protozoan Parasites ◽

Neonatal Calves ◽

Pathogenic Agents

AbstractIn the production and management of beef and dairy cattle, controlling diarrhea is one of the important concerns. Pathogenic agents of the disease, protozoan parasites including

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Randomly Amplified Polymorphic DNA PCR Analysis of Bovine Cryptosporidium parvum Strains Isolated from the Watershed of the Red River of the North

Applied and Environmental Microbiology ◽

10.1128/aem.64.6.2262-2265.1998 ◽

1998 ◽

Vol 64 (6) ◽

pp. 2262-2265 ◽

Cited By ~ 16

Author(s):

Kevin V. Shianna ◽

Russell Rytter ◽

Jonathan G. Spanier

Keyword(s):

Cryptosporidium Parvum ◽

Protozoan Parasite ◽

Geographic Area ◽

Red River ◽

Pcr Analysis ◽

Randomly Amplified Polymorphic Dna ◽

Strain Variation ◽

The North ◽

Neonatal Calves ◽

Dna Pcr

ABSTRACT Cryptosporidium parvum is a protozoan parasite that causes the disease cryptosporidiosis in a variety of mammals, including neonatal calves and humans. Millions of oocysts are shed during acute cryptosporidiosis, and zoonotic transmission is inferred, though not proven, to be a general phenomenon. Very little is known about the degree of strain variation exhibited by bovine and human isolates, though such knowledge would enable the amount of bovine-to-human transmission to be more precisely analyzed. This research was initiated to determine whether variations exist among bovine strains isolated from a localized geographic area, the watershed of the Red River of the North. Sixteen strains were isolated and compared to each other and to two human and two calf strains from Australia by randomly amplified polymorphic DNA PCR. A statistical analysis of the data indicated that the isolates belonged to four different groups of strains.

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