The “double-peak” pattern of pituitary adenoma intrasellar pressure and its impact on the microvascular structure

Intrasellar pressure (ISP) measurement technique has recently opened a new line of research in neuroendocrinology. The absolute and mean ISP values were investigated in 25 patients consecutively operated at the Brasilia University Hospital (DF). These data were correlated with serum prolactin levels, number of visual quadrant affected, tumor size, quality of life (measured through the SF-36 scale) and graded headache (measured through the HIT-6 scale). No correlation was observed. The p values were 0.887; 0.137; 0.892; 0.812 and 0.884; respectively. The HIT-6 values were inversely and moderately correlated with total RAND SF-36 and its mental and physical dimensions.

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Hyperprolactinemia, intrasellar pituitary tissue pressure, and the pituitary stalk compression syndrome

Journal of Neurosurgery ◽

10.3171/jns.1987.67.2.0192 ◽

1987 ◽

Vol 67 (2) ◽

pp. 192-196 ◽

Cited By ~ 48

Author(s):

Peter D. Lees ◽

John D. Pickard

Keyword(s):

Pituitary Adenoma ◽

Transsphenoidal Surgery ◽

Pituitary Stalk ◽

Consecutive Series ◽

Tissue Pressure ◽

Content Type ◽

Compression Syndrome ◽

The Mean ◽

Intrasellar Pressure ◽

Fine Print

✓ The intrasellar pressure has been studied in a consecutive series of 24 patients undergoing transsphenoidal surgery for pituitary adenoma. The mean intrasellar pressure for the group was 23 ± 2.5 mm Hg (± standard error of the mean), with a mean pulse pressure of 3.5 ± 1 mm Hg. The waveform partly resembled the arterial configuration. The results are correlated with the radiological and endocrinological features of the tumors. A hypothesis is proposed to explain the mechanism of hyperprolactinemia associated with the pituitary stalk compression syndrome.

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The incidence of COVID-19 in the Western Balkans has followed a double-peak pattern

Multi-dimensional Review of the Western Balkans - OECD Development Pathways ◽

10.1787/0da840d8-en ◽

2021 ◽

Keyword(s):

Western Balkans ◽

Double Peak ◽

Peak Pattern

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Intrasellar pressure and tumor volume in pituitary tumor: relation study

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2006000600016 ◽

2006 ◽

Vol 64 (4) ◽

pp. 971-975 ◽

Cited By ~ 16

Author(s):

Jackson A. Gondim ◽

Osvaldo I. Tella Jr. ◽

Michele Schops

Keyword(s):

Pituitary Adenoma ◽

Pituitary Tumor ◽

Tumor Volume ◽

Tumor Resection ◽

Type Ii ◽

Pressure Monitor ◽

Transseptal Approach ◽

Intrasellar Pressure ◽

Dural Opening ◽

Volume Method

OBJECTIVE: To determine if there was a relationship between intrassellar pressure (ISP) and pituitary tumor volume. METHOD: Between August 2002 and May 2004, 60 patients aged between 13 and 75 years old (39 males), having a pituitary adenoma were submitted to an endoscope transseptal approach. During the surgery and before tumor resection, 2 mm of the sella’s floor were removed and a 1.5 mm dural opening made to place a transducer into the pituitary adenoma. The transducer was connected to a pressure monitor. RESULTS: The intrasellar pressure, ranged from 2-51 mmHg and was measured based on the classification of Hardy-Vezina. The most elevated was in the type II macro adenomas with 32.6 mmHg, sharply superior to the value of a normal intracranial pressure. CONCLUSION: These values showed that the macroadenomas confined to the sella, without destruction of the floor and integrity of the diaphragm, type II of Hardy-Vezina, presented a value of ISP much higher than intra-extrasellar macroadenoma’s.

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Association of pituitary adenoma with neuronal christoma: A TEM study

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010016889x ◽

1994 ◽

Vol 52 ◽

pp. 232-233

Author(s):

Eva Horvath ◽

Kalman Kovacs ◽

B. W. Scheithauer ◽

R. V. Lloyd ◽

H. S. Smyth

Keyword(s):

Growth Hormone ◽

Pituitary Adenoma ◽

Pituitary Tumor ◽

Nervous Tissue ◽

Alternative Explanation ◽

Growth Hormone Releasing Hormone ◽

Cell Hyperplasia ◽

Releasing Hormone ◽

Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

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