scholarly journals Postnatal Weaning to Different Diets Leads to Different Reproductive Phenotypes in Female Offspring Following Perinatal Exposure to High Dietary AGEs

F&S Science ◽  
2021 ◽  
Author(s):  
Zaher Merhi ◽  
Xiu Quan Du ◽  
Maureen J. Charron
Keyword(s):  
Female Offspring ◽  
Perinatal Exposure

scholarly journals Perinatal exposure of female rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces central precocious puberty in the offspring

2008 ◽  
Vol 197 (2) ◽  
pp. 351-358 ◽  
Author(s):  
Masaki Kakeyama ◽  
Hideko Sone ◽  
Chiharu Tohyama
Keyword(s):  
Precocious Puberty ◽  
Low Dose ◽  
Female Offspring ◽  
Compensatory Hypertrophy ◽  
Female Rats ◽  
Perinatal Exposure ◽  
Dependent Manner ◽  
Early Maturation ◽  
Long Evans ◽  
Dose Dependent

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during the fetal and neonatal periods has been indicated to alter the development of the offspring later in life. In this study, we determined whether perinatal exposure to a low dose of TCDD affects the onset of puberty in the female offspring of Long-Evans hooded rats. On day 15 of gestation, pregnant female rats were administered TCDD by gavage at a single dose of 0 (vehicle), 200, or 800 ng/kg b.w. In the female offspring born to dams administered with TCDD at either 200 or 800 ng/kg b.w., the vaginal opening and first estrus occurred ∼4–7 days earlier than in the offspring born to vehicle-treated animals. The ovarian weight gain was also accelerated following exposure to TCDD in a dose-dependent manner. We next examined the ovarian compensatory hypertrophy (OCH) as an indicator of the maturation of the LH/GnRH-generating system in the pituitary and the hypothalamus. Exposure to TCDD accelerated the onset of OCH in the female offspring in a dose-dependent manner. In particular, in the offspring born to the dams exposed to TCDD at 800 ng/kg b.w., hypertrophy, which is characterized by hyperovulation and a marked increase in the weight of the remaining ovary after hemi-ovariectomy, was observed on postnatal days 27–30, which was 10 days earlier than in the offspring born to the vehicle-treated dams. These results indicate that perinatal exposure to a low dose of TCDD induces precocious puberty, including early maturation of the hypothalamic–pituitary axis, the gonads and genitals, in female Long-Evans hooded rats.

scholarly journals Effects of Perinatal Fluoxetine Exposure on Novelty-induced Social and Non-Social Investigation Behaviors in a Seminatural Environment

2021 ◽  
Author(s):  
Ole Christian Sylte ◽  
Jesper Solheim Johansen ◽  
Indrek Heinla ◽  
Danielle J Houwing ◽  
Jocelien DA Olivier ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Perinatal Period ◽  
Female Offspring ◽  
Social Aspects ◽  
Perinatal Exposure ◽  
Social Investigation ◽  
Adult Rat ◽  
Rat Offspring ◽  
Males And Females

AbstractSelective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various affective disorders during pregnancy. SSRIs cross the placenta and affect serotonergic neurotransmission in the fetus, but the neurobehavioral consequences for the offspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations in both social and non-social aspects of behavior. However, this research has mainly focused on behavior within simplified environments. The current study investigates the effects of perinatal SSRI exposure on social and non-social investigation behaviors of adult rat offspring upon introduction to a novel seminatural environment with unknown conspecifics. During the perinatal period (gestational day 1 until postnatal day 21), rat dams received daily treatment with either an SSRI (fluoxetine, 10 mg/kg) or vehicle. Adult male and female offspring were observed within the first hour after introduction to a seminatural environment. The results showed that perinatal fluoxetine exposure altered aspects of non-social investigation behaviors, while not altering social investigation behaviors. More specific, both fluoxetine exposed males and females spent more total time on locomotor activity than controls. Furthermore, fluoxetine exposed females spent less time exploring objects and specific elements in the environment. The data suggest that perinatal exposure to SSRIs leads to a quicker, less detailed investigation strategy in novel environments, and that the alteration is mostly pronounced in females.

scholarly journals Developmental exposure to DDT or DDE alters sympathetic innervation of brown adipose in adult female mice

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Annalise N. vonderEmbse ◽  
Sarah E. Elmore ◽  
Kyle B. Jackson ◽  
Beth A. Habecker ◽  
Katherine E. Manz ◽  
...  
Keyword(s):  
Adult Female ◽  
Sympathetic Neurons ◽  
Sympathetic Innervation ◽  
Female Offspring ◽  
Perinatal Exposure ◽  
Female Mice ◽  
Cl 316,243 ◽  
Brown Adipose ◽  
Increased Risk ◽  
Sympathetic Regulation

Abstract Background Exposure to the bioaccumulative pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) has been associated with increased risk of insulin resistance and obesity in humans and experimental animals. These effects appear to be mediated by reduced brown adipose tissue (BAT) thermogenesis, which is regulated by the sympathetic nervous system. Although the neurotoxicity of DDT is well-established, whether DDT alters sympathetic innervation of BAT is unknown. We hypothesized that perinatal exposure to DDT or DDE promotes thermogenic dysfunction by interfering with sympathetic regulation of BAT thermogenesis. Methods Pregnant C57BL/6 J mice were administered environmentally relevant concentrations of DDTs (p,p’-DDT and o,p’-DDT) or DDE (p,p’-DDE), 1.7 mg/kg and 1.31 mg/kg, respectively, from gestational day 11.5 to postnatal day 5 by oral gavage, and longitudinal body temperature was recorded in male and female offspring. At 4 months of age, metabolic parameters were measured in female offspring via indirect calorimetry with or without the β3 adrenergic receptor agonist, CL 316,243. Immunohistochemical and neurochemical analyses of sympathetic neurons innervating BAT were evaluated. Results We observed persistent thermogenic impairment in adult female, but not male, mice perinatally exposed to DDTs or p,p’-DDE. Perinatal DDTs exposure significantly impaired metabolism in adult female mice, an effect rescued by treatment with CL 316,243 immediately prior to calorimetry experiments. Neither DDTs nor p,p’-DDE significantly altered BAT morphology or the concentrations of norepinephrine and its metabolite DHPG in the BAT of DDTs-exposed mice. However, quantitative immunohistochemistry revealed a 20% decrease in sympathetic axons innervating BAT in adult female mice perinatally exposed to DDTs, but not p,p’-DDE, and 48 and 43% fewer synapses in stellate ganglia of mice exposed to either DDTs or p,p’-DDE, respectively, compared to control. Conclusions These data demonstrate that perinatal exposure to DDTs or p,p’-DDE impairs thermogenesis by interfering with patterns of connectivity in sympathetic circuits that regulate BAT. Graphical abstract

scholarly journals Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4010
Author(s):  
Ming-Kuei Shih ◽  
You-Lin Tain ◽  
Yu-Wei Chen ◽  
Wei-Hsuan Hsu ◽  
Yao-Tsung Yeh ◽  
...  
Keyword(s):  
Weight Gain ◽  
Bisphenol A ◽  
Intestinal Microbiota ◽  
Lipid Accumulation ◽  
Blood Lipids ◽  
Serum Biochemistry ◽  
Female Offspring ◽  
Perinatal Exposure ◽  
Fat Deposits ◽  
Potential Applications

Resveratrol butyrate esters (RBE) are derivatives of resveratrol (RSV) and butyric acid and exhibit biological activity similar to that of RSV but with higher bioavailability. The aim of this study was designed as an animal experiment to explore the effects of RBE on the serum biochemistry, and fat deposits in the offspring rats exposed to bisphenol A (BPA), along with the growth and decline of gut microbiota. We constructed an animal model of perinatal Bisphenol A (BPA) exposure to observe the effects of RBE supplementation on obesity, blood lipids, and intestinal microbiota in female offspring rats. Perinatal exposure to BPA led to weight gain, lipid accumulation, high levels of blood lipids, and deterioration of intestinal microbiota in female offspring rats. RBE supplementation reduced the weight gain and lipid accumulation caused by BPA, optimised the levels of blood lipids, significantly reduced the Firmicutes/Bacteroidetes (F/B) ratio, and increased and decreased the abundance of S24-7 and Lactobacillus, respectively. The analysis of faecal short-chain fatty acid (SCFA) levels revealed that BPA exposure increased the faecal concentration of acetate, which could be reduced via RBE supplementation. However, the faecal concentrations of propionate and butyrate were not only significantly lower than that of acetate, but also did not significantly change in response to BPA exposure or RBE supplementation. Hence, RBE can suppress BPA-induced obesity in female offspring rats, and it demonstrates excellent modulatory activity on intestinal microbiota, with potential applications in perinatological research.

scholarly journals Perinatal Exposure of Mice to the Pesticide DDT Impairs Energy Expenditure and Metabolism in Adult Female Offspring

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103337 ◽  
Author(s):  
Michele La Merrill ◽  
Emma Karey ◽  
Erin Moshier ◽  
Claudia Lindtner ◽  
Michael R. La Frano ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Adult Female ◽  
Female Offspring ◽  
Perinatal Exposure

scholarly journals Effects of perinatal fluoxetine exposure on novelty-induced social and non-social investigation behaviors in a seminatural environment

2021 ◽  
Author(s):  
Ole Christian Sylte ◽  
Jesper Solheim Johansen ◽  
Indrek Heinla ◽  
Danielle J. Houwing ◽  
Jocelien D. A. Olivier ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Perinatal Period ◽  
Female Offspring ◽  
Social Aspects ◽  
Perinatal Exposure ◽  
Social Investigation ◽  
Adult Rat ◽  
Rat Offspring ◽  
Males And Females

AbstractSelective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various affective disorders during pregnancy. SSRIs cross the placenta and affect serotonergic neurotransmission in the fetus, but the neurobehavioral consequences for the offspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations in both social and non-social aspects of behavior. However, this research has mainly focused on behavior within simplified environments. The current study investigates the effects of perinatal SSRI exposure on social and non-social investigation behaviors of adult rat offspring upon introduction to a novel seminatural environment with unknown conspecifics. During the perinatal period (gestational day 1 until postnatal day 21), rat dams received daily treatment with either an SSRI (fluoxetine, 10 mg/kg) or vehicle. Adult male and female offspring were observed within the first hour after introduction to a seminatural environment. The results showed that perinatal fluoxetine exposure altered aspects of non-social investigation behaviors, while not altering social investigation behaviors. More specifically, both fluoxetine-exposed males and females spent more total time on locomotor activity than controls. Furthermore, fluoxetine-exposed females spent less time exploring objects and specific elements in the environment. The data suggest that perinatal exposure to SSRIs leads to a quicker, less detailed investigation strategy in novel environments and that the alteration is mostly pronounced in females.

scholarly journals Perinatal maternal chronic exposure to dibutyl phthalate promotes visceral obesity in adult female offspring

2021 ◽  
Author(s):  
Kunyan Zhou ◽  
Ran Cheng ◽  
Meina Yang ◽  
Xiaoyang Shen ◽  
Xiaoyan Luo ◽  
...  
Keyword(s):  
Adult Female ◽  
Dibutyl Phthalate ◽  
Corn Oil ◽  
Visceral Obesity ◽  
Female Offspring ◽  
Perinatal Exposure ◽  
Fat Percentage ◽  
Protein Levels ◽  
Significant Difference ◽  
Visceral Adipose

IntroductionMaternal exposure to dibutyl phthalate (DBP) may result in glucolipid dysfunction in female offspring. However, the underlying mechanisms remain elusive. We hypothesized that chronic maternal DBP exposure could induce abnormal metabolism of glucolipid.Materials and methodsSprague-Dawley rats were intraperitoneally injected with different doses of DBP, estradiol, and corn oil from gestational day 7 until the end of lactation. The weights, visceral fat percentage, serum lipid, insulin and glucose, protein levels of PI3K signal pathway in muscle were detected in F1 female offspring.ResultsAlthough the birth weight of F1 female offspring was not different among groups, the weights were heavier in DBP groups from postnatal day 7 to adult (P<0.001). The visceral adipose percentage in adult female offspring was increased by perinatal exposure to DBP (P<0.001). Decreased serum levels of triglyceride (P<0.0001), fasting glucose (P=0.004), prolactin (P=0.006), HOMA-IR (P=0.014) were found in female offspring exposed to DBP, but no difference for fasting insulin, total cholesterol, adiponectin. Increased protein levels of p-AKT, but decreased PTEN and GPR30 were observed in muscle of female offspring in DBP group, but without significant difference. None difference was observed for the protein levels of PI3K, AKT, GLUT4, InsR and IRS-1.ConclusionMaternal perinatal exposure to DBP induced obesity and accumulation of visceral adipose tissue for the adult female offspring. Serum glucolipid and local signal transduction of PTEN/PI3K/AKT pathway in muscle were not adversely affected by perinatal exposure to DBP for adult female offspring.

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