scholarly journals Effect of Absorption Behavior of Solubilizers on Drug Dissolution in the Gastrointestinal Tract: Evaluation Based on In Vivo Luminal Concentration–Time Profile of Cilostazol, a Poorly Soluble Drug, and Solubilizers

2016 ◽  
Vol 105 (9) ◽  
pp. 2825-2831 ◽  
Author(s):  
Yusuke Tanaka ◽  
Atsuo Kubota ◽  
Akira Matsuo ◽  
Ayaka Kawakami ◽  
Hiroki Kamizi ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Time Profile ◽  
Drug Dissolution ◽  
Concentration Time ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

scholarly journals Polymeric nanoparticles based topical gel of poorly soluble drug: Formulation, ex-vivo and in vivo evaluation

2017 ◽  
Vol 6 (2) ◽  
pp. 184-191 ◽  
Author(s):  
Mohammed Elmowafy ◽  
Ahmed Samy ◽  
Abdelaziz E. Abdelaziz ◽  
Khaled Shalaby ◽  
Ayman Salama ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Polymeric Nanoparticles ◽  
Drug Formulation ◽  
In Vivo Evaluation ◽  
Topical Gel ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

scholarly journals Physicochemical Variation in Nanogold-Based Ayurved Medicine Suvarna Bhasma Produced by Various Manufacturers Lead to Different In Vivo Bioaccumulation Profiles

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110110
Author(s):  
Snehasis Biswas ◽  
Mukesh Chawda ◽  
Kapil Thakur ◽  
Ramacharya Gudi ◽  
Jayesh Bellare
Keyword(s):  
Peak Concentration ◽  
Biological Properties ◽  
Time Profile ◽  
Gold Concentration ◽  
Concentration Time ◽  
Microscopic Morphology ◽  
Based Medicine ◽  
General Appearance ◽  
Ionic Gold

Suvarna Bhasma (SB) is a gold particle-based medicine that is used in Ayurved to treat tuberculosis, arthritis and nervous diseases. Traditionally, the Ayurved preparation processes of SB do exist, but they are all long, tedious and involve several steps. Due to this, there is a possibility of bypassing the necessary Ayurved processes or non-adherence to all steps or use of synthetic gold particles. Our aim is to characterize 5 commercial SB preparations from 5 different manufacturers. A comparative physicochemical, pharmacokinetic (PK) and bioaccumulation study was carried out on all the 5 SB preparations. The general appearance such as color and texture of these 5 samples were different from each other. The size, shape and gold concentration (from 32-98 wt%) varied among all the 5 SBs. The accumulation of ionic gold in zebrafish and gold concentration profiles in rat blood were found to be significantly different for all the 5 SBs. Non-compartmental PK model obtained from the concentration-time profile showed significant differences in various PK parameters such as peak concentration (Cmax), half-life (t1/2) and terminal elimination slope (λz) for all the 5 SB preparations. SB-B showed the highest Cmax (8.55 μg/L), whereas SB-D showed the lowest Cmax (4.66 μg/L). The dissolution of ionic gold from SBs in zebrafish tissue after the oral dose had a 5.5-fold difference between the highest and lowest ionic gold concentrations. All the 5 samples showed distinct physicochemical and biological properties. Based on characteristic microscopic morphology, it was found that 2 preparations among them were suspected of being manufactured by non-adherence to the mentioned Ayurved references.

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