Comparative Assessment of Miniaturized Screening Approaches for Selection of Polymers for Amorphous Drug Stabilization

2018 ◽  
Vol 107 (3) ◽  
pp. 897-908 ◽  
Author(s):  
Alamelu Banda ◽  
Arushi Manchanda ◽  
Wei Zhang ◽  
Grace May Alba ◽  
Karthik Nagapudi
Keyword(s):  
Comparative Assessment ◽  
Drug Stabilization ◽  
Amorphous Drug ◽  
Selection Of ◽  
Screening Approaches

Comparative Assessment of Resistance of Hardwearing Anodes, Ternary Coated with Iridium, Ruthenium and Titanium

2017 ◽  
Vol 265 ◽  
pp. 580-586 ◽  
Author(s):  
L.N. Fesenko ◽  
I.V. Pchelnikov ◽  
R.V. Fedotov
Keyword(s):  
Black Sea ◽  
Sodium Hypochlorite ◽  
Sodium Salt ◽  
Sea Water ◽  
Comparative Assessment ◽  
The Black Sea ◽  
Current Voltage ◽  
Iridium Oxides ◽  
Corrosive Resistance ◽  
Selection Of

A selection of anode coatings has been studied to get sodium hypochlorite in low concentrationduring the electrolysis of 3% solution of sodium salt and the Black Sea water. The corrosive resistance of anodes has been determined, with different batches of ruthenium and iridium oxides, as well as their characteristics: chlorine outlet while passing throughthe current, voltage on the cell, the dynamics of concentration growth of available chlorine in solution.

Excipients That Facilitate Amorphous Drug Stabilization

2015 ◽  
pp. 463-495
Author(s):  
Yangjie Wei ◽  
Bhaswati Dattachowdhury ◽  
Kiran K. Vangara ◽  
Niraja Patel ◽  
Kenneth Alexander ◽  
...  
Keyword(s):  
Drug Stabilization ◽  
Amorphous Drug

Amorphous drug stabilization using mesoporous materials

2020 ◽  
pp. 151-166
Author(s):  
Danillo F.M.C. Veloso ◽  
Matthias M. Knopp ◽  
Korbinian Löbmann
Keyword(s):  
Mesoporous Materials ◽  
Drug Stabilization ◽  
Amorphous Drug

scholarly journals DEVELOPMENT OF METHODS FOR ASSESSMENT AND SELECTION OF UNMANNED AERIAL VEHICLE FOR MINE RECONNAISSANCE

ScienceRise ◽  
2020 ◽  
pp. 44-50
Author(s):  
Vadym Neroba
Keyword(s):  
Unmanned Aerial Vehicle ◽  
Comparative Assessment ◽  
Problem Solution ◽  
Special Equipment ◽  
Long Time ◽  
Aerial Vehicle ◽  
Scientific Results ◽  
The One ◽  
Selection Of ◽  
Technological Product

Object of research: comparative assessment and selection of an unmanned aerial vehicle for mine reconnaissance sample. Investigated problem: substantiation of the methodological apparatus for comparative assessment and selection of an unmanned aerial vehicle for mine reconnaissance sample, taking into consideration the presence of both quantitative and qualitative indicators. Main scientific results: the methods of comparative assessment and selection of an unmanned aerial vehicle for mine reconnaissance sample is developed. The technique is based on an expert method, which allows a drone sample to be evaluated and selected objectively, taking into consideration the presence of both quantitative and qualitative indicators. At the same time, group interaction and discussion of experts are realized. When the judgments do not coincide, an artificial consensus is not imposed. The number of experts is not limited. The experts are not linked in any way. The need to ensure transitive consistency (10–12 %) makes it possible to record attempts by an expert (experts) to artificially overestimate the indicators of one of the drone samples (or the one being evaluated), therefore, the indicators of another sample will automatically deteriorate. The principle of impartiality and fairness is maintained. A well-trained objective coordinator is not required, and the reality is that the absence of the disrupting the problem solution possibility is due to a change in the psychological situation among the experts. Area of practical use of research results: humanitarian demining in the interests of ensuring the detection of mines for various purposes by sappers from a safe distance. At the same time, an increase within the probability of mines detecting is ensured due to special equipment installed onboard the drone. Innovative technological product: a technique has been developed that allows not only assessing the drone samples for mine reconnaissance objectively, but making an objective choice of a sample for specific requirements also. Scope of application of the innovative technological product: clearance of the terrain remaining after the end of hostilities. With the help of unmanned aerial vehicles, a significant acceleration of the demining process is possible, especially in those territories where mines are installed and being for a sufficiently long time.

scholarly journals The study of the sociospatial aspect of green building in St.Petersburg: theoretical and practical aspects

2019 ◽  
Vol 135 ◽  
pp. 03054 ◽  
Author(s):  
Tamara Orlovskaya ◽  
Svetlana Ershova
Keyword(s):  
Quality Of Life ◽  
Green Building ◽  
Comparative Assessment ◽  
The Other ◽  
Large Cities ◽  
The One ◽  
The City ◽  
Paired Analysis ◽  
Selection Of

The article discusses the modern problems of green building. The duality of the greening problem in large cities is noted: on the one hand, this is one of the factors of conflict, on the other hand, the factor of the quality of life, creativity of the city, and its image level. The selection of factors for the analysis was carried out taking into account the research of Russian and foreign scientists and the possibility of obtaining reliable statistics. The study was conducted according to the landscaping of the districts of St. Petersburg. As a result of the study, clustering of St. Petersburg districts was carried out according to greenery indicators, the level of green construction in each of the considered territories of the city was estimated. A paired analysis of indicators made it possible to identify the most problematic areas of the city, to conduct a comparative assessment of the districts according to the level of greenery and their sufficiency to create a comfortable environment

METHODS FOR ASSESSING MICROBIOLOGICAL CONTAMINATION AND ACTIVITY OF DISINFECTING DRUGS IN THE PRODUCTION OF FOOD PRODUCTS

2021 ◽  
Vol 1 (3) ◽  
pp. 309-316
Author(s):  
E.M. Lenchenko ◽  
◽  
A.M. Abdullaeva ◽  
A.Yu. Dragunova ◽  
D.I. Udavliev ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Food Production ◽  
Raw Materials ◽  
Comparative Assessment ◽  
Frequency Of Occurrence ◽  
Technological Equipment ◽  
Microbiological Contamination ◽  
Environmental Objects ◽  
Selection Of ◽  
Shape And Size

The article presents the results of a comparative assessment and selection of effective methods for assessing microbiological contamination and the activity of disinfectants in the food production. At assessing the degree of microbiological decontamination in food production, the use of «Dip-slide», a polymer plate coated with the «Oxoid» medium, saves material costs and research time, as well as excludes subjective factors. The general regularities of the stages of formation of heterogeneous biofilms of microorganisms in the study of food raw materials, products, technological equipment and environmental objects have been revealed. At the first stage, the adhesion of vegetative forms of bacteria occurs, which have a shape and size typical of the species. Due to the coaggregation of cells, a monolayer of microorganisms was formed in the form of a diffuse layer. There were also identified secondary microcolonies associated with primary ones and separated by matrix voids, in the microcavities, the formation of cell strands in the form of beams was revealed. Dispersion of microcolonies was accompanied by the destruction of the extracellular matrix and the separation of cells capable of attaching to the surface and forming new microcolonies. Under the influence of various concentrations of chemotherapeutic and disinfecting drugs, the frequency of occurrence of clusters – the aggregation of microorganisms united by a layer of the extracellular matrix – significantly decreased.

scholarly journals Study on Mechanism for Amorphous Drug Stabilization Using Gelucire 50/13

2009 ◽  
Vol 57 (9) ◽  
pp. 937-942 ◽  
Author(s):  
Shamkant Laxman Shimpi ◽  
Kakasaheb Ramoo Mahadik ◽  
Anant Raghunath Paradkar
Keyword(s):  
Drug Stabilization ◽  
Amorphous Drug

Comparative assessment and selection of electric vehicle diffusion models: A global outlook

Energy ◽  
2022 ◽  
Vol 238 ◽  
pp. 121932
Author(s):  
Rajeev Ranjan Kumar ◽  
Pritha Guha ◽  
Abhishek Chakraborty
Keyword(s):  
Electric Vehicle ◽  
Diffusion Models ◽  
Comparative Assessment ◽  
Selection Of

scholarly journals Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics

2021 ◽  
Author(s):  
Daniel R. Wong ◽  
Jay Conrad ◽  
Noah Johnson ◽  
Jacob I. Ayers ◽  
Annelies Laeremans ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Throughput Screening ◽  
Biological Processes ◽  
Fluorescent Markers ◽  
Therapeutic Compounds ◽  
Tau Aggregation ◽  
A Current ◽  
Selection Of ◽  
Screening Approaches

In microscopy-based drug screens, fluorescent markers carry critical information on how compounds affect different biological processes. However, practical considerations may hinder the use of certain fluorescent markers. Here, we present a deep learning method for overcoming this limitation. We accurately generated predicted fluorescent signals from other related markers, and validated this new machine learning (ML) method on two biologically distinct datasets. We used the ML method to improve the selection of potentially efficacious therapeutic compounds for Alzheimer's disease (AD) from high-content high-throughput screening (HCS). The ML method identified novel compounds that effectively blocked tau aggregation, which would have been missed by traditional screening approaches unguided by ML. The ML method also improved triaging efficiency of compound rankings over a current in-house screening approach. We reproduced this ML method on a biologically independent cancer-based dataset, demonstrating its generalizability. The approach is disease-agnostic, and applicable across fluorescence microscopy datasets.

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