Mechanism of Drug Release From Temperature-Sensitive Formulations Composed of Low-Melting-Point Microcrystalline Wax

As a drug delivery carrier, a novel pH/temperature sensitive bead (pTSB) with core-shelled structure from poly(N-acryloylglycine) (PAG), copoly(N-acryloylglycine methyl este and N-acryloylglycine ethyl ester) was prepared by two steps. In pH=7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the pTSB was about 60.1 % within 500 mins, but this value only reached to 22.3 % in pH=2.1 PBS. The release behaviors of indomethacin from pTSB also exhibited a remarkable dependence on PAG content in the core. Additionally, the release rate of indomethacin was much faster at 18 oC than that at 37 oC due to the temperature sensitivity of poly(N-acryloylglycinates). The experimental results indicate that pTSB seems to have a potential application in the drug release system controlled via pH or temperature in the biomedical fields.

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Data on the experiments of temperature-sensitive hydrogels for pH-sensitive drug release and the characterizations of materials

Data in Brief ◽

10.1016/j.dib.2018.01.042 ◽

2018 ◽

Vol 17 ◽

pp. 419-423 ◽

Cited By ~ 5

Author(s):

Wei Zhang ◽

Xin Jin ◽

Heng Li ◽

Run-run Zhang ◽

Cheng-wei Wu

Keyword(s):

Drug Release ◽

Ph Sensitive ◽

Temperature Sensitive

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Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

International Journal of Polymeric Materials ◽

10.1080/00914037.2021.1960333 ◽

2021 ◽

pp. 1-16

Author(s):

Ceyda Şimşek ◽

Candan Erbil

Keyword(s):

Drug Release ◽

Temperature Sensitive

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A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO2 Nano-Platform

Journal of Nanoelectronics and Optoelectronics ◽

10.1166/jno.2021.3071 ◽

2021 ◽

Vol 16 (7) ◽

pp. 1029-1036

Author(s):

Hongzhu Wang ◽

Mengxun Chen ◽

Liping Song ◽

Youju Huang

Keyword(s):

Drug Delivery ◽

Block Copolymer ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Photothermal Therapy ◽

Drug Loading ◽

Temperature Sensitive

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

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Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors

Pharmaceutics ◽

10.3390/pharmaceutics12111007 ◽

2020 ◽

Vol 12 (11) ◽

pp. 1007

Author(s):

Mohamadreza Amin ◽

Wenqiu Huang ◽

Ann L. B. Seynhaeve ◽

Timo L. M. ten Hagen

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Cellular Level ◽

Advanced Technology ◽

Temperature Sensitive ◽

Triggered Release ◽

Adjuvant Effect ◽

Triggered Drug Release ◽

High Level ◽

External Stimuli

Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials.

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DEVELOPMENT AND EVALUATION OF CIPROFLOXACIN HYDROCHLORIDE LOADED OCULAR INSERT BY USING “PLANTAGO OVATA” AS NATURAL POLYMER

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2018v10i4.28474 ◽

2018 ◽

Vol 10 (4) ◽

pp. 79

Author(s):

Ayushi Chourasia ◽

Shikha Agrawal

Keyword(s):

Melting Point ◽

Drug Release ◽

Release Profile ◽

Natural Polymer ◽

Plantago Ovata ◽

In Vitro Drug Release ◽

Ciprofloxacin Hydrochloride ◽

Long Acting ◽

Ocular Insert

Objective: The present work focus in the direction of “Development and evaluation of Ciprofloxacin Hydrochloride loaded ocular insert by using “plantago ovata” as natural polymer”. The current work was carried out to evaluate the control release profile of ocular insert. Natural polymer in ocular insert was used for studying the long acting property. Natural polymer is also used to enhance the bioavailability of drug and reduce toxicity. It is also used to increase the duration of action of drug for prolongs action and gives better in vitro performance as compare than to the conventional ocular formulation.Methods: Solvent casting method was used in the formulation of Ciprofloxacin Hydrochloride loaded ocular inserts. Different ocular insert formulations of varying polymer concentration were prepared. Ocular insert formulation H-1 to H-3 was prepared by using different concentration of HPMC and formulation P-1 to P-4 was prepared by using different concentration of Plantago Ovata.Results: The ocular inserts formulation was within the acceptable limits. All the pre formulation parameters of polymers such as derived properties, compressibility index, Hausner’s ratio, viscosity, melting point, swelling ratio, loss on drying, PH of mucilage solution and pre formulation of active pharmaceutical ingredient such as estimation of drug by using UV spectroscopy, determination of melting point, solubility, partition coefficient and FTIR for compatibility study of drug and excipient were evaluation. FTIR analysis also confirmed no drug-excipient interaction.Conclusion: Prepared inserts in the present study were semitransparent. The mixing of the drug in to the polymer is uniform, due to this; the drug content of all formulation is good. Formulation P4 was selected because it showed better release profile, drug content and other physicochemical properties than other formulated batch when compare. All the prepared inserts showed in vitro drug release for the period of 4 h as compare to the marketed formulation. An in vitro drug release study revealed that ocular formulation gives a prolong action. The formulation was found to be long acting.

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Nanoencapsulation of a water soluble drug in biocompatible polyesters. Effect of polyesters melting point and glass transition temperature on drug release behavior

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2010.09.004 ◽

2010 ◽

Vol 41 (5) ◽

pp. 636-643 ◽

Cited By ~ 43

Author(s):

Vassilios Karavelidis ◽

Dimitrios Giliopoulos ◽

Evangelos Karavas ◽

Dimitrios Bikiaris

Keyword(s):

Glass Transition ◽

Transition Temperature ◽

Glass Transition Temperature ◽

Melting Point ◽

Drug Release ◽

Water Soluble ◽

Release Behavior ◽

Drug Release Behavior ◽

Water Soluble Drug

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Injectable Surfactant Included-Virgin Coconut Oil with and without Ibuprofen

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.581-582.108 ◽

2012 ◽

Vol 581-582 ◽

pp. 108-111 ◽

Cited By ~ 1

Author(s):

Sumuntana Anuchatkidjaroen ◽

Thawatchai Phaechamud

Keyword(s):

Drug Release ◽

Physical Properties ◽

Cloud Point ◽

Pour Point ◽

Polarized Light ◽

Coconut Oil ◽

Temperature Sensitive ◽

Virgin Coconut Oil ◽

Wax Deposition

In the tropical countries, virgin coconut oil (VCO) has been abundantly utilized as traditional medicine and cosmetic, but its major problem is temperature sensitive. This oil changes into some wax-like at cool environment. The purpose of this study is to decrease wax deposition of this oil by investigate the effect of surfactants on the physical properties and drug release characteristic. Ibuprofen (IB), which can soluble in VCO, was used as a model drug. Viscosity, pour point, cloud point and polarized light microscope examinations were conducted to characterize the change of VCO physical properties. In vitro drug release experiment was performed using dialysis method at 50 rpm and 37°C in phosphate buffer pH 7.4. The addition of surfactants in VCO increased the efficiency for measuring the viscosity at lower temperature. Result from viscosity measurement indicated that Solutol® HS15 (ST) was the most suitable for choosing as representative of the surfactants. Both pour point and cloud point could not reduce by ST because the crystals size of VCO with and without ST was not different. There was no difference of viscosity of each formula during the release experiments (37°C), therefore the release rate of drug from VCO containing or without ST was not different. These indicated that the surfactants and ibuprofen affected the physical properties but did not affect the release of this investigated VCO.

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