A pan-cancer analysis of the oncogenic role of staphylococcal nuclease domain-containing protein 1 (SND1) in human tumors

Abstract Background In recent years, there have been many studies on the relationship between DLGAP5 and different types of cancers, yet there is no pan-cancer analysis of DLGAP5. Therefore, this study aims to analyze the roles of DLGAP5 in human tumors. Methods Firstly, we evaluated the expression level of DLGAP5 in 33 types of tumors throughout the datasets of TCGA (Cancer Genome Atlas) and GEO (Gene Expression Synthesis). Secondly, we used the GEPIA2 and Kaplan-Meier plotter to conduct Survival prognosis analysis. Additionally, cBioPortal web was utilized to analyze the genetic alteration of DLGAP5, after which we selected hepatocellular carcinoma (HCC) cell lines to define the function of DLGAP5. Last but not least, we performed immune infiltration analysis and DLGAP5-related gene enrichment analysis. Results DLGAP5 is highly expressed in most type of cancers, and there is a significant correlation between the expression of DLGAP5 and the prognosis of cancer patients. We have observed that DLGAP5 promotes the proliferation and invasion of hepatocellular carcinoma (HCC) cell lines. We also found that DLGAP5 expression was related with the CD8+ T-cell infiltration status in kidney renal clear cell carcinoma, uveal melanoma, and thymoma, and cancer-associated fibroblast infiltration was observed in breast invasive carcinoma, kidney renal papillary cell carcinoma and testicular germ cell tumors. In addition, enrichment analysis revealed that cell cycle- and oocyte meiosis-associated functions were involved in the functional mechanism of DLGAP5. Conclusions Taken together, our unpresented pan-cancer analysis of DLGAP5 provides a relatively integrative understanding of the oncogenic role of DLGAP5 in various tumors. DLGAP5 may prompt HCC cellular proliferation, invasion and metastasis. All of these provides solid basement and will promote more advanced understanding the role of DLGAP5 in tumorigenesis and development from the perspective of clinical tumor samples and cells.

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Systematic Analysis of the Oncogenic Role of WDR62 in Human Tumors

Disease Markers ◽

10.1155/2021/9940274 ◽

2021 ◽

Vol 2021 ◽

pp. 1-23

Author(s):

Yulan Bu ◽

Lihua Zhang ◽

Xiaolin Ma ◽

Rui Wang ◽

Xuecheng Zhang ◽

...

Keyword(s):

Poor Prognosis ◽

Immune Cell ◽

Treg Cells ◽

Human Tumors ◽

Systematic Analysis ◽

Kaplan Meier ◽

Promoter Dna ◽

Underlying Mechanisms ◽

Pan Cancer

Background. Emerging studies support the oncogenic role of WD repeat domain 62 (WDR62) in few tumors, while no pan-cancer analysis is available. In this study, we analyzed systematically the oncogenic role of WDR62 across a series of human tumors based on bioinformatic data mining. Methods. The expression level of WDR62 was analyzed via GEPIA2, TIMER, UALCAN, and StarBase databases. The prognostic role was analyzed via GEPIA2, TIMER, UALCAN, StarBase, TISIDB, TCGA portal, Kaplan-Meier Plotter, and PrognoScan databases. Then, we explored the causes for WDR62 abnormal expression via TCGA portal and UALCAN databases. Subsequently, the STRING and GeneMANIA databases were used to find the interactive networks for WDR62. Furthermore, we analyzed the correlation between WDR62 expression and immune features via TIMER and TISIDB databases. Results. We found that WDR62 was significantly upregulated in most of the tumors and correlated with poor prognosis mainly in 6 candidate tumors—BLCA, BRCA, KIRC, KIRP, LIHC, and LUAD. Abnormal WDR62 expression may be probably attributed to TP53 mutation and promoter DNA methylation. Relative network analysis demonstrated that WDR62 was mainly involved in MAPK and toll-like receptor signaling pathway. WDR62 expression was associated with various immune cell infiltrations, especially cancer-associated fibroblasts (CAF) and T cell regulatory (Treg) cells, and was markedly correlated with poor prognosis. Moreover, WDR62 expression was closely associated with the expression of some immunomodulators such as PD-L1 and has a significant prognostic value. Conclusions. Our study revealed that WDR62 could serve as a diagnostic and prognostic biomarker for several cancers. Importantly, WDR62 was closely associated with various immune cell infiltration, and to a certain extent, it can predict the effect of immunotherapy in particular PD1/PD-L1 inhibitors. Our pan-cancer study provided useful information on the oncogenic role of WDR62, contributing to further exploring the underlying mechanisms.

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A Pan-Cancer Analysis of the Oncogenic Role of G Protein-Coupled Bile Acid Receptor 1(GPBAR1) in Human Tumors

SSRN Electronic Journal ◽

10.2139/ssrn.3922628 ◽

2021 ◽

Author(s):

Zhiyuan Guan ◽

Xiao Jin ◽

Shengfu Liu ◽

Zhong Wu ◽

Ruijun Cong ◽

...

Keyword(s):

Bile Acid ◽

G Protein ◽

Human Tumors ◽

Acid Receptor ◽

Bile Acid Receptor ◽

G Protein Coupled ◽

Pan Cancer

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A Pan-Cancer Analysis of the Oncogenic Role of Integrin Beta4 (ITGB4) in Human Tumors

International Journal of General Medicine ◽

10.2147/ijgm.s341076 ◽

2021 ◽

Vol Volume 14 ◽

pp. 9629-9645

Author(s):

Wenjie Huang ◽

Li Fan ◽

Yongmei Tang ◽

Yinxiu Chi ◽

Jingjing Li

Keyword(s):

Human Tumors ◽

Integrin Beta4 ◽

Pan Cancer

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A pan-cancer analysis of molecular characteristics and oncogenic role of hexokinase family genes in human tumors

Life Sciences ◽

10.1016/j.lfs.2020.118669 ◽

2021 ◽

Vol 264 ◽

pp. 118669

Author(s):

Mingzhe Jiang ◽

Shuangjie Liu ◽

Jiaxing Lin ◽

Wenjun Hao ◽

Baojun Wei ◽

...

Keyword(s):

Human Tumors ◽

Molecular Characteristics ◽

Pan Cancer

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A Pan-Cancer Analysis of the Oncogenic Role of Twinfilin Actin Binding Protein 1 in Human Tumors

Frontiers in Oncology ◽

10.3389/fonc.2021.692136 ◽

2021 ◽

Vol 11 ◽

Author(s):

Gengwei Huo ◽

Yali Wang ◽

Jinliang Chen ◽

Ying Song ◽

Cuicui Zhang ◽

...

Keyword(s):

Binding Protein ◽

Gene Expression Omnibus ◽

Human Tumors ◽

The Cancer Genome Atlas ◽

Actin Binding ◽

Driver Gene ◽

Comprehensive Overview ◽

Actin Binding Protein ◽

Pan Cancer

BackgroundUnderstanding common and unique mechanisms driving oncogenic processes in human tumors is indispensable to develop efficient therapies. Recent studies have proposed Twinfilin Actin Binding Protein 1 (TWF1) as a putative driver gene in lung cancer, pancreatic cancer and breast cancer, however a systematic pan-cancer analysis has not been carried out.MethodsHere, we set out to explore the role of TWF1 in 33 tumor types using TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus) dataset, Human Protein Atlas (HPA), and several bioinformatic tools.ResultsAs part of our analysis, we have assessed TWF1 expression across tumors. We found that over-expression of TWF1 generally predicted poor OS for patients with tumors with high TWF1 expression, such as mesothelioma, lung adenocarcinoma, cervical cancer and pancreatic adenocarcinoma. We also assessed the mutation burden of TWF1 in cancer and the TWF1-associated survival of cancer patients, compared the phosphorylation of TWF1 between normal and primary tumor tissues and explored putative functional mechanisms in TWF1-mediated oncogenesis.ConclusionsOur pan-cancer analysis provides a comprehensive overview of the oncogenic roles of TWF1 in multiple human cancers.

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An integrative pan-cancer analysis reveals the oncogenic role of mutS homolog 6 (MSH6) in human tumors

Aging ◽

10.18632/aging.203745 ◽

2021 ◽

Author(s):

Haibo Zhan ◽

Fengbo Mo ◽

Qiang Xu ◽

Song Wang ◽

Bin Zhang ◽

...

Keyword(s):

Human Tumors ◽

Pan Cancer

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Correlated overexpression of metadherin and SND1 in glioma cells

Biological Chemistry ◽

10.1515/hsz-2015-0174 ◽

2016 ◽

Vol 397 (1) ◽

pp. 57-65 ◽

Cited By ~ 7

Author(s):

Liping Tong ◽

Chao Wang ◽

Xuebin Hu ◽

Bo Pang ◽

Zhonghui Yang ◽

...

Keyword(s):

Poor Prognosis ◽

Glioma Cell ◽

Expression Patterns ◽

Glioma Cells ◽

Staphylococcal Nuclease ◽

Primary Brain Tumor ◽

Interacting Protein ◽

Nuclease Domain ◽

Primary Glioma

Abstract Glioma is the most common primary brain tumor with poor prognosis. Effective treatment of glioma remains a big challenge due to complex pathogenic mechanisms. Previous studies have shown that metadherin (MTDH) and its interacting protein staphylococcal nuclease domain containing 1 (SND1) are overexpressed in many solid tumors. To elucidate the role of MDTH and SND1 in the pathogenesis of glioma, we examined the expression of MTDH and SND1 in primary glioma tissues and found that both MTDH and SND1 were highly expressed, with similar expression patterns. Co-expression of MTDH and SND1 was associated with advanced glioma grades. In addition, we detected the interaction between MTDH and SND1 in cultured glioma cell lines. MTDH could promote the expression of p65 and SND1 in glioma cells. However, enhanced SND1 expression by MTDH was abolished by the inhibition of p65. In conclusion, we demonstrated high expression levels MTDH and SND1 in primary glioma tissues. MTDH might promote glioma by inducing SND1 expression through the activation of NF-κB pathway. MTDH and SND1 may serve as the indicator of malignancy and prognosis as well as therapeutic targets for patients with glioma.

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