scholarly journals Hormonal contraceptive phases matter: Resting-state functional connectivity of emotion-processing regions under stress

2020 ◽  
Vol 13 ◽  
pp. 100276
Author(s):  
Padideh Nasseri ◽  
Alexandra Ycaza Herrera ◽  
Katherine Gillette ◽  
Sophia Faude ◽  
Jessica D. White ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Emotion Processing ◽  
Hormonal Contraceptive ◽  
Resting State Functional Connectivity

scholarly journals Resting-state functional connectivity of emotion regulation networks in euthymic and non-euthymic bipolar disorder patients

2016 ◽  
Vol 34 ◽  
pp. 56-63 ◽  
Author(s):  
G. Rey ◽  
C Piguet ◽  
A Benders ◽  
S Favre ◽  
SB Eickhoff ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Clinical Symptoms ◽  
Mood State ◽  
A Priori ◽  
Emotion Processing ◽  
Population Sample ◽  
Small Population ◽  
Resting State Functional Connectivity

AbstractBackgroundPrevious functional magnetic resonance imaging studies in bipolar disorder (BD) have evidenced changes in functional connectivity (FC) in brain areas associated with emotion processing, but how these changes vary with mood state and specific clinical symptoms is not fully understood.MethodsWe investigated resting-state FC between a priori regions of interest (ROIs) from the default-mode network and key structures for emotion processing and regulation in 27 BD patients and 27 matched healthy controls. We further compared connectivity patterns in subgroups of 15 euthymic and 12 non-euthymic patients and tested for correlations of the connectivity strength with measures of mood, anxiety, and rumination tendency. No correction for multiple comparisons was applied given the small population sample and pre-defined target ROIs.ResultsOverall, regardless of mood state, BD patients exhibited increased FC of the left amygdala with left sgACC and PCC, relative to controls. In addition, non-euthymic BD patients showed distinctive decrease in FC between right amygdala and sgACC, whereas euthymic patients showed lower FC between PCC and sgACC. Euthymic patients also displayed increased FC between sgACC and right VLPFC. The sgACC–PCC and sgACC–left amygdala connections were modulated by rumination tendency in non-euthymic patients, whereas the sgACC-VLPFC connection was modulated by both the current mood and tendency to ruminate.ConclusionsOur results suggest that sgACC-amygdala coupling is critically affected during mood episodes, and that FC of sgACC play a pivotal role in mood normalization through its interactions with the VLPFC and PCC. However, these preliminary findings require replication with larger samples of patients.

scholarly journals Impaired left amygdala resting state functional connectivity in subthreshold depression individuals

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaoling Peng ◽  
Way K. W. Lau ◽  
Chanyu Wang ◽  
Lingfang Ning ◽  
Ruibin Zhang
Keyword(s):  
Depressive Symptoms ◽  
Functional Connectivity ◽  
Resting State ◽  
Emotion Processing ◽  
Subthreshold Depression ◽  
Healthy Controls ◽  
Imaging Data ◽  
Resting State Functional Connectivity ◽  
Pathophysiological Mechanisms ◽  
Wide Range

Abstract Subthreshold depression (StD) affects people who experience clinically relevant depressive symptoms, which does not meet the diagnostic criteria for major depressive disorder (MDD). StD represents an ideal model for understanding the pathophysiological mechanisms of depression. Impaired emotion processing is a core feature of depression; careful investigation is required to better understand the neural correlates of emotion processing in depressed populations. In the current study, we explored whether the resting-state functional connectivity of the amygdala, a hub that taps a wide range of brain areas involved in emotion processing, is altered in individuals with StD when compared with healthy controls. Resting-state imaging data was collected from 59 individuals with StD and 59 age- and gender-matched controls. We found that the resting-state functional connectivity of the left amygdala with the cognitive control network and the left insula was significantly lower in people with StD than that in healthy controls. Such association was not observed in the right amygdala. Furthermore, functional connectivity strength between the left amygdala and the left precuneus was positively associated with depressive symptoms in individuals with StD. Our findings are in line with those reported in subjects with MDD, which may assist in further elucidating the pathophysiological mechanisms of depression, and contribute to the development of tailored treatments for individuals with StD who are at high risk of developing MDD.

scholarly journals Altered resting-state functional connectivity in emotion-processing brain regions in adults who were born very preterm

2016 ◽  
Vol 46 (14) ◽  
pp. 3025-3039 ◽  
Author(s):  
C. Papini ◽  
T. P. White ◽  
A. Montagna ◽  
P. J. Brittain ◽  
S. Froudist-Walsh ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Emotion Processing ◽  
Recognition Task ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Resting State Functional Connectivity ◽  
Dynamic Stimuli ◽  
Posterior Cingulate ◽  
Very Preterm

BackgroundVery preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in emotion regulation, social competence and communicative skills. However, the neuroanatomical mechanisms underlying such impairments have not been systematically studied. Here we investigated the functional integrity of the amygdala connectivity network in relation to the ability to recognize emotions from facial expressions in VPT adults.MethodThirty-six VPT-born adults and 38 age-matched controls were scanned at rest in a 3-T MRI scanner. Resting-state functional connectivity (rs-fc) was assessed with SPM8. A seed-based analysis focusing on three amygdalar subregions (centro-medial/latero-basal/superficial) was performed. Participants’ ability to recognize emotions was assessed using dynamic stimuli of human faces expressing six emotions at different intensities with the Emotion Recognition Task (ERT).ResultsVPT individuals compared to controls showed reduced rs-fc between the superficial subregion of the left amygdala, and the right posterior cingulate cortex (p = 0.017) and the left precuneus (p = 0.002). The VPT group further showed elevated rs-fc between the left superficial amygdala and the superior temporal sulcus (p = 0.008). Performance on the ERT showed that the VPT group was less able than controls to recognize anger at low levels of intensity. Anger scores were significantly associated with rs-fc between the superficial amygdala and the posterior cingulate cortex in controls but not in VPT individuals.ConclusionsThese findings suggest that alterations in rs-fc between the amygdala, parietal and temporal cortices could represent the mechanism linking VPT birth and deficits in emotion processing.

Relating Disinhibited Eating Behaviors to Resting State Functional Connectivity in Young Children

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1889-P
Author(s):  
ALLISON L.B. SHAPIRO ◽  
SUSAN L. JOHNSON ◽  
BRIANNE MOHL ◽  
GRETA WILKENING ◽  
KRISTINA T. LEGGET ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Young Children ◽  
Resting State ◽  
Eating Behaviors ◽  
Resting State Functional Connectivity ◽  
Disinhibited Eating

scholarly journals The effect of congenital blindness on resting-state functional connectivity revisited

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria J. S. Guerreiro ◽  
Madita Linke ◽  
Sunitha Lingareddy ◽  
Ramesh Kekunnaya ◽  
Brigitte Röder
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Visual Experience ◽  
Brain Regions ◽  
State Condition ◽  
Resting State Functional Connectivity ◽  
Congenital Blindness ◽  
Eyes Closed ◽  
Congenitally Blind ◽  
Eyes Open

AbstractLower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition—as well as to evaluate the effect of resting state condition on group differences in RSFC—, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between ‘visual’ and non-‘visual’ circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.

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