Usefulness of echocardiographic determined tricuspid regurgitation in predicting event-free survival in severe heart failure secondary to idiopathic-dilated cardiomyopathy or to ischemic cardiomyopathy

1998 ◽  
Vol 82 (10) ◽  
pp. 1301-1303 ◽  
Author(s):  
Judy Hung ◽  
Todd Koelling ◽  
Marc J. Semigran ◽  
G.William Dec ◽  
Robert A. Levine ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Tricuspid Regurgitation ◽  
Ischemic Cardiomyopathy ◽  
Severe Heart Failure ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Event Free Survival ◽  
Free Survival

The Save Procedure For Idiopathic Dilated Cardiomyopathy With Severe Heart Failure

2006 ◽  
Vol 1 (4) ◽  
pp. 195-196
Author(s):  
Hisayoshi Suma ◽  
Hiroaki Tanabe ◽  
Akihito Takahashi ◽  
Junya Yamada ◽  
Tadashi Isomura ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Severe Heart Failure ◽  
Idiopathic Dilated Cardiomyopathy

scholarly journals Pathogenic Variants Associated with Dilated Cardiomyopathy Predict Outcome in Pediatric Myocarditis

2021 ◽  
Author(s):  
Franziska Seidel ◽  
Manuel Holtgrewe ◽  
Nadya Al-Wakeel-Marquard ◽  
Bernd Opgen-Rhein ◽  
Josephine Dartsch ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Enrichment Analysis ◽  
Event Free Survival ◽  
Genetic Characteristics ◽  
Free Survival ◽  
Coronary Syndrome ◽  
Pathogenic Variants ◽  
Common Causes ◽  
Significant Enrichment

Background - Myocarditis is one of the most common causes leading to heart failure in children and a possible genetic background has been postulated. We sought to characterize the clinical and genetic characteristics in patients with myocarditis ≤18 years of age to predict outcome. Methods - A cohort of 42 patients (MYCPEDIG) with biopsy-proven myocarditis underwent genetic testing with targeted panel sequencing of cardiomyopathy-associated genes. MYCPEDIG patients were divided into subgroups according to the phenotype of dilated cardiomyopathy (DCM) at presentation, resulting in 22 patients without DCM (MYC-NonDCM) and 20 patients with DCM (MYC-DCM). Results - MYC-DCM patients (median age 1.4 years) were younger than MYC-NonDCM patients (median age 16.1 years; p<0.001) and were corresponding to heart failure-like and coronary syndrome-like phenotypes, respectively. At least one likely pathogenic/pathogenic (LP/P) variant was identified in 9/42 patients (22%), 8 of them were heterozygous, and 7/9 were in MYC-DCM. LP/P variants were found in genes validated for primary DCM ( BAG3 , DSP , LMNA , MYH7 , TNNI3 , TNNT2 , and TTN ). Rare variant enrichment analysis revealed significant accumulation of high impact disease variants in MYC-DCM versus healthy individuals (p=0.0003). Event-free survival was lower (p=0.008) in MYC-DCM patients compared to MYC-NonDCM and primary DCM. Conclusions - We report heterozygous LP/P variants in biopsy-proven pediatric myocarditis. Myocarditis patients with DCM phenotype were characterized by early-onset heart failure, significant enrichment of LP/P variants, and poor outcome. These phenotype- and age-group specific findings will be useful for personalized management of these patients. Genetic evaluation in children newly diagnosed with myocarditis and DCM phenotype is warranted.

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